Advancements in Cancer Biomarkers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 672
Special Issue Editor
Interests: cancer genetics; biomarkers; SABR; brachytherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following the discovery of the first tumor biomarker by Henry Bence-Jones in 1847, the study of new cancer biomarkers has accelerated, propelled onwards by advancements in molecular technology. The identification of novel cancer biomarkers now utilizes modified immunoassay, molecular hybridization, next-generation nucleic acid sequencing, gene amplification, gene editing and liquid biopsy technology.
Within the current era of innovation and development, recent publications have explored the use of circulating tumor DNA (ctDNA) and circulating micro-RNA (c-miRNA) for the diagnosis and prognosis of colorectal cancer, esophageal cancer and non-small cell lung cancer. The unique methylation profile of cancer cells identified from gene methylation can differentiate between several gastrointestinal cancers, which can be used to predict the origin of tumors in metastatic disease. Tumor-infiltrating lymphocytes (TILs) have prognostic potential in triple-negative breast cancer and are predictors of patients’ response in melanoma. TILs have even been studied for their therapeutic potential, leading to the FDA approval of Lifileucel for advanced melanoma, demonstrating the importance of molecular studies in transforming our understanding at the cellular level and driving precision medicine. Proteomics and metabolomics further represent emerging research, with attempts to identify cancer-specific biomarkers and predict drug sensitivity in ovarian and breast cancer through mass spectrometry.
Within the cornucopia of available literature on cancer biomarkers, the International Journal of Molecular Sciences (IJMS) has published over 500 articles on cancer biomarkers in the last two years alone and continues to pioneer experimental and theoretical progress. This Special Issue focuses on advancements in cancer biomarkers to update and orientate the scientific community on the continual expansive field of molecular oncology. We hope to unite specialists from various disciplines, including molecular biology, biochemistry, biophysics, biogenetics, computational biology and biotechnology, including artificial intelligence.
This Special Issue is led by Dr. Christos Mikropoulos and assisted by our GE's Assistant Editor, Dr. Michael Hannides (<michael.hannides@nhs.net>, Clinical Oncology, Royal Surrey NHS Foundation Trust, Egerton Road, Surrey, Guildford GU2 7XX, UK). Please note that this Special Issue is focused on molecular research, so pure clinical research will not be accepted, but we welcome clinical submissions with biomolecular experiments.
Dr. Christos Mikropoulos
Guest Editor
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Keywords
- biomarkers
- ctDNA
- mircroRNA
- proteomics
- gene methylation
- TIL
- transcriptomics
- micro RNA
- tumor microenvironment
- gene methylation
- proteomics
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