Focus on Chemoradiation Resistance: The Challenge of Cancer Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 28
Special Issue Editors
Interests: chemotherapy; cancer; regional chemotherapy; intraarterial infusion chemotherapy
Special Issue Information
Dear Colleagues,
Despite remarkable advances in cancer therapy, chemoradiation resistance continues to limit therapeutic success and remains a major clinical challenge. This phenomenon is driven by a complex interplay of intrinsic tumor characteristics, adaptive cellular responses, and microenvironmental factors that allow malignant cells to survive and proliferate under treatment pressure. Mechanistic insights into DNA repair pathways, tumor heterogeneity, and immune evasion have provided a foundation for developing novel strategies to circumvent resistance, yet translating these findings into clinical practice remains an ongoing challenge.
This Special Issue, Focus on Chemoradiation Resistance: The Challenge of Cancer Therapy, seeks to highlight current understanding and emerging concepts in this rapidly evolving field. We aim to integrate findings from basic research, translational studies, and clinical trials to foster a multidisciplinary dialogue on how to predict, monitor, and overcome resistance. By emphasizing both biological mechanisms and therapeutic innovation, this collection aspires to inform future personalized treatment strategies and ultimately improve patient survival and quality of life.
Key topics covered in this Special Issue include the following:
- Genetic, epigenetic, and metabolic determinants of chemoradiation resistance;
- Tumor microenvironmental influences and immune system interactions;
- DNA damage response pathways and novel radiosensitizers/chemosensitizers;
- Predictive and prognostic biomarkers for treatment response;
- Emerging therapeutic combinations and personalized medicine strategies;
- Concentration-dependent therapy and chemotherapy optimization.
Prof. Dr. Karl Reinhard Aigner
Prof. Dr. Hendrikx Marc José Henri
Guest Editors
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Keywords
- genetic, epigenetic, and metabolic determinants of chemoradiation resistance
- tumor microenvironmental influences and immune system interactions
- DNA damage response pathways and novel radiosensitizers/chemosensitizers
- predictive and prognostic biomarkers for treatment response
- emerging therapeutic combinations and personalized medicine strategies
- concentration-dependent therapy and chemotherapy optimization
- intra-arterial infusion and isolated perfusion chemotherapy
- quality of life
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