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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Therapeutic Targets for Musculoskeletal Tumors

edited by Japneet Kaur

submission deadline 31 Oct 2026 | Viewed by 180 | Submission Open

Keywords: musculoskeletal tumors; sarcoma; bone metastasis; tumor microenvironment; targeted therapy; immunotherapy; biomarkers; drug resistance; signaling pathways; cancer biology

(This special issue belongs to the Section Molecular Oncology)

The Multiple Roles of RNA and RNases

edited by

Ester Boix

submission deadline 31 Oct 2026 | Viewed by 180 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA-binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Molecular Biology)

Insights on the Efficacy and Safety of Cytotoxic Agents in Lung Cancer

edited by

João G. Costa

and

Nuno G. Oliveira

submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open

Keywords: lung cancer; cytotoxic agents; chemotherapy; antibody–drug conjugates; non-small-cell lung cancer; small-cell lung cancer; drug safety; platinum-based chemotherapy; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Molecular Immunology and Defenses: Oral and Periodontal Health

edited by Evangelos Papathanasiou

submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open

Keywords: periodontal disease; immune response; host defense; inflammation; immune regulation

(This special issue belongs to the Section Molecular Immunology)

Discovery, Synthesis, and Therapeutic Applications of Enzyme Inhibitors

edited by

Christophe Morisseau

submission deadline 31 Oct 2026 | Viewed by 173 | Submission Open

Keywords: cardiovascular diseases; neuroinflammation; neurodegeneration; cancer; clinical trial

(This special issue belongs to the Section Biochemistry)

Molecular Biology of Histone Demethylases

edited by

Rodolfo Negri

submission deadline 31 Oct 2026 | Viewed by 173 | Submission Open

Keywords: histone demethylase and transcriptional regulation; histone demethylase function; histone demethylase and cancer; histone methylation and genotoxic damage; histone demethylase expression

(This special issue belongs to the Section Molecular Biology)

The Role of Protein Kinase in Health and Diseases, 2nd Edition

edited by

Manuela Loi

submission deadline 31 Oct 2026 | Viewed by 173 | Submission Open

Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; meta-bolic diseases

(This special issue belongs to the Section Molecular Biology)

Application of Genome Editing in Crop Improvement for Abiotic Stress Resistance

edited by

Jingjun Ruan

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: genome editing; crop improvement; abiotic stress resistance; CRISPR-Cas9; crop breeding; food security; agricultural sustainability

(This special issue belongs to the Section Molecular Plant Sciences)

Nutrient Sensing in Human Metabolic Disorders

edited by

Ayşegül Sümer

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: nutrient sensing; obesity; insulin resistance; type 2 diabetes; metabolic disease; adipokines; AMPK; mTOR; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Environmental Genomics and Epigenomics: Response, Development and Disease

edited by

William Tse

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: developmental toxicology; environmental genomics; environmental pollutants; gene–environment interaction; integrated omics; transgenerational effects; environmental health; risk assessment

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Molecular Biomaterials for Pollutants Removal

edited by Jarosław Chwastowski and

Paweł Staroń

submission deadline 31 Oct 2026 | Viewed by 170 | Submission Open

Keywords: biomaterials; biosorption; biodegradation; microorganisms; isotherm and kinetic modeling; organic sorbents

(This special issue belongs to the Section Materials Science)

Advanced Drug Delivery Systems: From Nanocarrier Design to Translation Application

edited by Santu Sarkar

submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open

Keywords: nanocarriers; clinical translation; targeted delivery; immunogenicity; formulation strategies

(This special issue belongs to the Section Molecular Nanoscience)

Natural Products and Functional Biomaterials in Wound Healing and Cancer Treatment

edited by Shaik Nyamathulla

submission deadline 31 Oct 2026 | Viewed by 168 | Submission Open

Keywords: cancer; wound healing; biomaterials; diabetes; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nano–Plant Interactions: Molecular Mechanisms and Applications in In Vitro Systems

edited by

Danuta Kulpa

submission deadline 31 Oct 2026 | Viewed by 168 | Submission Open

Keywords: nano–plant interactions; nanomaterials; nanoparticle uptake; plant tissue cultures; nanoparticle-induced molecular responses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research and Insight in Plant Genetic Breeding

edited by

Bing He

submission deadline 31 Oct 2026 | Viewed by 161 | Submission Open

Keywords: plant genetic breeding; crop genomics; gene editing; molecular markers; functional genomics; germplasm enhancement; omics breeding; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Beyond the Single Gene: The Polygenic Architecture of Drug Response

edited by

Leonardo Beltrán-Angarita

submission deadline 31 Oct 2026 | Viewed by 160 | Submission Open

Keywords: pharmacogenomics; pharmacogenetics; polygenic architecture; polygenic risk scores; precision medicine; adverse drug reactions; epistasis/gene–gene interactions; genomic biomarkers

(This special issue belongs to the Section Molecular Pharmacology)

Ion Channel in Physiology

edited by Isaac E. García

submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open

Keywords: ion channels; channel gating mechanisms; structure–function relationships; electrophysiology; cryo-electron microscopy (cryo-EM); connexin hemichannels and gap junctions; pannexin channels; ion transporters; cell signaling and homeostasis; channelopathies

(This special issue belongs to the Section Molecular Biophysics)

Overcoming Membrane Protein Challenges with Computational Methods

edited by

Lorant Janosi

submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open

Keywords: membrane protein; structural and functional properties; computational approaches; molecular dynamics; free energy calculations; computational docking and drug design approaches

(This special issue belongs to the Section Macromolecules)

Protein S in Coagulation, Inflammation, and Cancer

edited by

Rinku Majumder

submission deadline 31 Oct 2026 | Viewed by 156 | Submission Open

Keywords: Protein S; hemostasis; anticoagulation; inflammation; cancer biology; thrombotic disorders; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Nanobodies and Monoclonal Antibodies: Epitope, Structure and Neutralization

edited by David Vance

submission deadline 31 Oct 2026 | Viewed by 154 | Submission Open

Keywords: monoclonal antibody; nanobody; antibody-antigen interactions; epitope mapping; neutralizing mechanisms; structural biology; vaccine design

(This special issue belongs to the Section Molecular Nanoscience)

Respiratory Tract Infections: Molecular Pathogenesis, Advanced Diagnostics, and Translational Strategies

edited by Roy Rillera Marzo

submission deadline 31 Oct 2026 | Viewed by 151 | Submission Open

Keywords: respiratory tract infections; host–pathogen interactions; molecular diagnostics; genomics and proteomics; antimicrobial resistance; biomarkers; immune response; precision medicine; translational research; infectious disease epidemiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Lipid Signaling in Cardiovascular and Metabolism-Associated Diseases

edited by

Nathalie Mercier

submission deadline 31 Oct 2026 | Viewed by 147 | Submission Open

Keywords: bioactive lipids; inflammation; lipid metabolism; lipid signaling pathways; cardiovascular and metabolism-associated diseases; cellular phenotype; lipid receptors; cardiovascular treatments; lipidomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Collagen and Lipid-Based Nanoagents/Nanoparticles: Chemical Investigation and Delivery

edited by

Riyanto Teguh Widodo

submission deadline 31 Oct 2026 | Viewed by 146 | Submission Open

Keywords: collagen nanoparticles; lipid nanoparticles; drug delivery system; nanocarriers; liposomes; niosomes; nanostructured lipid carriers; biocompatibility; surface functionalisation; nanoagents; molecular characterisation; controlled release

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Functional Materials for Environmental Remediation and Ecosystem Sustainability

edited by Chenyu Wang

submission deadline 31 Oct 2026 | Viewed by 139 | Submission Open

Keywords: functional nanomaterials; environmental remediation; water pollution control; self-assembled systems; ecosystem sustainability; advanced adsorbents; catalysis and oxidation; polyphosphate-based materials; green chemistry; environmental sensors

(This special issue belongs to the Section Molecular Nanoscience)

New Predictive Biomarkers for Ovarian Cancers

edited by

Olga Lilia Garibay-Cerdenares

submission deadline 31 Oct 2026 | Viewed by 130 | Submission Open

Keywords: ovarian cancer; biomarkers; chemorresistance; nanotechnology; ovarian cancer signaling; metabolic plasticity in ovarian cancer; omics in ovarian cancer

(This special issue belongs to the Section Molecular Oncology)

Aging, Regeneration and Stem Cell Biology of Fascial Tissue

edited by

Carla Stecco

and

Zhao Xiaoxiao

submission deadline 31 Oct 2026 | Viewed by 87 | Submission Open

Keywords: fascia; aging; regeneration; stem cells; extracellular matrix; fibrosis; mechanobiology; mesenchymal stem cells; tissue repair; myofascial pain

(This special issue belongs to the Section Molecular Biology)

Spike Protein Receptor

edited by

Salvatore Giovanni De Simone

submission deadline 15 Nov 2026 | Viewed by 276 | Submission Open

Keywords: spike protein; receptor binding; ACE2 interaction; viral entry; structural virology; immune recognition; antibody and IgA epitopes; variant transmissibility; receptor-blocking therapeutics

(This special issue belongs to the Section Molecular Biophysics)

Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Nov 2026 | 4 articles | Viewed by 29474 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 20 Nov 2026 | 5 articles | Viewed by 20767 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2026 | 3 articles | Viewed by 18764 | Submission Open

Keywords: neurovascular diseases; blood–brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 20 Nov 2026 | 9 articles | Viewed by 16292 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics and Genomics of Tumors, 2nd Edition

edited by

Petra Korać

submission deadline 20 Nov 2026 | 11 articles | Viewed by 12955 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advancing Regenerative Medicine: Basic Research and Translation in Clinics

edited by

Dragan Primorac

submission deadline 20 Nov 2026 | 4 articles | Viewed by 10849 | Submission Open

Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics

(This special issue belongs to the Section Molecular Biology)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Nov 2026 | 4 articles | Viewed by 9676 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Nov 2026 | 3 articles | Viewed by 9609 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Nov 2026 | 3 articles | Viewed by 8544 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Nov 2026 | 3 articles | Viewed by 7244 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in Neuroscience

edited by

Sarmistha Mitra

submission deadline 20 Nov 2026 | 3 articles | Viewed by 7240 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Nov 2026 | 1 articles | Viewed by 5786 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

and Inta Liepniece-Karele

submission deadline 20 Nov 2026 | 4 articles | Viewed by 5617 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 20 Nov 2026 | 4 articles | Viewed by 5389 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genomics, Genetics, and the Future of Fruit Improvement

edited by Zoe Hilioti

submission deadline 20 Nov 2026 | 3 articles | Viewed by 4389 | Submission Open

Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Nov 2026 | 1 articles | Viewed by 3559 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Molecular Research on Dyslipidemia

edited by

Aleksandra Zeljkovic

and

Jelena Vekić

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3530 | Submission Open

Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action

edited by

Piotr Dobrzynski

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2908 | Submission Open

Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers, loaded with silver ions, or antibiotics; antibacterial nano- and micro particles; anticoagulant layers

(This special issue belongs to the Section Materials Science)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2560 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Current Research on Colloidal Emulsions: Preparation and Applications

edited by Alexander Djerdjev

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2472 | Submission Open

Keywords: emulsion formulation and stability; nano-, micro-, and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil–water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology

(This special issue belongs to the Section Materials Science)

Allergic Reactions and Immune Factors

edited by

Liborija Lugovic-Mihic

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2233 | Submission Open

Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy

(This special issue belongs to the Section Molecular Immunology)

Flow Cytometry as a Tool for Diagnostics and Biomarker Research

edited by

Leslie Chavez-Galan

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2196 | Submission Open

Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2145 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1351-1400 on page 28 of 64.

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