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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research in Bamboo, Tree, Grass, and Other Forest Products—2nd Edition
edited by
submission deadline 31 Aug 2026 | Viewed by 282 | Submission Open
Keywords: bamboo; tree; grass; molecular biology; gene function
(This special issue belongs to the Section Molecular Plant Sciences)
Tissue Regeneration Mechanisms and Applications in Degenerative and Inflammatory Diseases
edited by
submission deadline 31 Aug 2026 | Viewed by 281 | Submission Open
Keywords: regenerative medicine; stem cells; inflammation; degenerative disease models; extracellular matrix remodeling and intracellular signaling; tissue engineering; biomaterials and bioactive scaffolds; organoids; translational and cell-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bacteriophages in the One Health Perspective: From Infection Therapy to Precision Medicine Through Diagnostics
edited by
submission deadline 31 Aug 2026 | Viewed by 275 | Submission Open
Keywords: bacteriophages; one health concept; bacteriophage therapy
(This special issue belongs to the Section Molecular Microbiology)
Multi-Omics Perspectives on Psychiatric Disorders: From Molecular Mechanisms to Clinical Translation
edited by Veronica Sfredel and Madalina Iuliana Mușat
submission deadline 31 Aug 2026 | Viewed by 267 | Submission Open
Keywords: molecular psychiatry; psychiatric multi-omics; neurobiological pathways; psychiatric biomarkers; gene–environment interactions; translational psychiatry; computational psychiatry
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies of Endothelial Dysfunction
edited by Alexandru Emil Caraba
submission deadline 31 Aug 2026 | Viewed by 259 | Submission Open
Keywords: atherosclerosis; cardiovascular diseases; chronic kidney disease; endothelial dysfunction; inflammation; inflammatory rheumatic diseases; metabolic syndrome; nailfold capillaroscopy; nitric oxide
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Determinants of Response and Resistance in Cancer Immunotherapy
edited by
submission deadline 31 Aug 2026 | Viewed by 253 | Submission Open
Keywords: immune checkpoint inhibitors; adoptive cell therapies; cancer vaccines; tumor microenvironment remodeling; neoantigen dynamics; biomarker discovery; translational approaches to overcome therapeutic resistance
(This special issue belongs to the Section Molecular Oncology)
Transition Metal Complexes: Recent Advances and Future Perspectives
edited by
submission deadline 31 Aug 2026 | Viewed by 252 | Submission Open
Keywords: transition metal complexes; crystal and molecular structure; spectroscopic properties; magnetic properties; biological activity; pharmacological application; catalysis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Histamine Receptors: Biology, Pharmacology, and Therapeutic Potential
edited by
submission deadline 31 Aug 2026 | Viewed by 251 | Submission Open
Keywords: histamine; histamine receptor agonist; histamine receptor antagonist; signal transduction; polymorphisms
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Pathophysiology and Immunology Related to Lung Cancer
edited by and Luigi Della Gravara
submission deadline 31 Aug 2026 | Viewed by 250 | Submission Open
Keywords: lung cancer; NSCLC; SCLC; tumor immunology; immune checkpoints inhibitors; targeted therapy; epithelial–immune crosstalk; precision oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Exhaustive Chase: Investigation of Striated Muscle Regulation in Health and Disease
edited by P. Bryant Chase, and Michael Butcher
submission deadline 31 Aug 2026 | Viewed by 248 | Submission Open
Keywords: striated muscle contractility; thin filament regulation; calcium activation; cardiomyopathy; muscle energetics; muscle fiber mechanics; single fiber mechanics; muscle plasticity; muscle functional adaptation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
DNA Damage, Immune Signaling and Beyond submission deadline 31 Aug 2026 | Viewed by 242 | Submission Open
Keywords: DNA damage response; immune signaling; genomic instability; cellular senescence; chronic inflammation; cancer and aging
(This special issue belongs to the Section Molecular Immunology)
Molecular Research on Insect-Symbiont Interactions
edited by Chen Luo
submission deadline 31 Aug 2026 | Viewed by 236 | Submission Open
Keywords: insect; endosymbiont; phenotypic effects; molecular mechanisms; immunity; resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Design, Synthesis and Evaluation of Anticancer Agents
edited by
submission deadline 31 Aug 2026 | Viewed by 233 | Submission Open
Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Mechanistics Insights in Antidepressants: Charting New Pathways for Future Research
edited by Lucía Martínez-Mota
submission deadline 31 Aug 2026 | Viewed by 209 | Submission Open
Keywords: antidepressants; neuroplasticity; neurogenesis; neuronal excitability; treatment-resistant depression; major depression disorder
(This special issue belongs to the Section Molecular Pharmacology)
Glaucoma: From Molecular Mechanisms to Innovative Therapeutics
edited by Da-Wen Lu
submission deadline 31 Aug 2026 | Viewed by 206 | Submission Open
Keywords: neuroprotection; reinal ganglion cell; therapeutic strategies; Rho kinase inhibitor; molecular research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Endocannabinoid Research
edited by Elisabetta Murru
submission deadline 31 Aug 2026 | Viewed by 205 | Submission Open
Keywords: endocannabinoid system; N-acylethanolamine (NAE); CB1 and CB2 receptors; lipid mediators; nutrition; dietary fatty acids; energy metabolism; metabolic homeostasis; neuroinflammation
(This special issue belongs to the Section Biochemistry)
Deciphering the Cellular Antiviral and Anti-Inflammatory Signalling Orchestrated by Plant-Derived Bioactives submission deadline 31 Aug 2026 | Viewed by 205 | Submission Open
Keywords: immunological aspects of herpesvirus infections; role of PCD in pathogenesis of viral infections; functional studies of UL49 and UL41 structural proteins during HSV replication; involvement of ERK1 pathway in the modu-lation of CCR5 receptor; studies of cyclodextrin carriers as drug or nucleic acid delivery systems for cancer therapy; imaging for antiviral treatment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases
edited by
submission deadline 10 Sep 2026 | 7 articles | Viewed by 11732 | Submission Open
Keywords: genetic diseases; genotype–phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cellular and Molecular Progression of Cardiovascular Diseases: 2nd Edition submission deadline 10 Sep 2026 | 5 articles | Viewed by 4433 | Submission Open
Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exercise in Health and Diseases: From the Molecular Perspectives
edited by and Danielle Dias
submission deadline 10 Sep 2026 | 4 articles | Viewed by 3650 | Submission Open
Keywords: exercise physiology; molecular mechanisms of exercise; exercise-induced cellular signaling; metabolic signaling pathways; redox biology and exercise
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Properties and Applications of Nanoparticles and Nanomaterials: 4th Edition
edited by Xiaogang Li
submission deadline 10 Sep 2026 | 1 articles | Viewed by 1070 | Submission Open
Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Nanomaterials for Targeted Therapy and Drug Delivery
edited by Ceren Kimna
submission deadline 10 Sep 2026 | Viewed by 359 | Submission Open
Keywords: nanocarriers ; targeted therapies ; translational nanomedicine ; nano-bio interactions
(This special issue belongs to the Section Molecular Nanoscience)
Pain: From Bench to Bedside
edited by and Robert J. Yong
submission deadline 20 Sep 2026 | 1 articles | Viewed by 56081 | Submission Open
Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers
edited by Alessandra Bettiol
submission deadline 20 Sep 2026 | 13 articles | Viewed by 44187 | Submission Open
Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation
edited by
submission deadline 20 Sep 2026 | 6 articles | Viewed by 40338 | Submission Open
Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood–brain barrier; blood–cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites
edited by
submission deadline 20 Sep 2026 | 14 articles | Viewed by 33362 | Submission Open
Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights in Antibody Therapy
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 20319 | Submission Open
Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease
(This special issue belongs to the Section Molecular Immunology)
Type 2 Diabetes: Molecular Pathophysiology and Treatment
edited by
submission deadline 20 Sep 2026 | 7 articles | Viewed by 19489 | Submission Open
Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Understanding Aging in Health and Disease
edited by
submission deadline 20 Sep 2026 | 6 articles | Viewed by 17243 | Submission Open
Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging
(This special issue belongs to the Section Molecular Biology)
Renin-Angiotensin System in Health and Diseases
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 17234 | Submission Open
Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurological Diseases: From Pathogenesis to Molecular Diagnosis and Treatment submission deadline 20 Sep 2026 | 13 articles | Viewed by 16407 | Submission Open
Keywords: Alzheimer's disease; Parkinson's disease; Huntington's disease; epilepsy; stroke; neurological diseases; treatment of neurological diseases
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 16044 | Submission Open
Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies
(This special issue belongs to the Section Biochemistry)
25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics submission deadline 20 Sep 2026 | 15 articles | Viewed by 15491 | Submission Open
Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 14733 | Submission Open
Keywords: dystonia; Parkinson’s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Advances in Diabetes Research and Practice
edited by Ezekiel Uba Nwose
submission deadline 20 Sep 2026 | 9 articles | Viewed by 14261 | Submission Open
Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Computer-Aided Drug Design Strategies submission deadline 20 Sep 2026 | 3 articles | Viewed by 14072 | Submission Open
Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques
(This special issue belongs to the Section Molecular Informatics)
Antibody Engineering and Therapeutic Applications
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 13910 | Submission Open
Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action
(This special issue belongs to the Section Molecular Pharmacology)
Cancer Drug Treatment and Cancer Cell Drug Resistance submission deadline 20 Sep 2026 | 3 articles | Viewed by 13809 | Submission Open
Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Inner Ear Disorders: From Molecular Mechanisms to Treatment
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 13770 | Submission Open
Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects
(This special issue belongs to the Section Molecular Immunology)
Advances in the Genetics, Epidemiology and Management of Myopathies submission deadline 20 Sep 2026 | 2 articles | Viewed by 13702 | Submission Open
Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia
(This special issue belongs to the Section Molecular Biology)
Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis
edited by Alberto Gajofatto
submission deadline 20 Sep 2026 | 5 articles | Viewed by 13658 | Submission Open
Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 20 Sep 2026 | 3 articles | Viewed by 13634 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins, resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 13370 | Submission Open
Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins, enzymes, ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases
edited by
submission deadline 20 Sep 2026 | 7 articles | Viewed by 12918 | Submission Open
Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Elucidating How Chondrocytes Maintain Cartilage Stability
edited by James A. Martin
submission deadline 20 Sep 2026 | 7 articles | Viewed by 12217 | Submission Open
Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix
(This special issue belongs to the Section Molecular Biology)
Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 12169 | Submission Open
Keywords: Parkinson’s disease; neurodegenerative disorders; α-synuclein aggregation; neuroinflammation; gene therapy; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 11531 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Structures, Syntheses of Natural Products, and Their Biological Effects
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 11206 | Submission Open
Keywords: structures of natural products; syntheses; biological effects; biomedical applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms, Pathogenesis, and Novel Therapeutic Strategies in Cardiovascular Disease, 2nd Edition
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 11051 | Submission Open
Keywords: aneurysm pathobiology; vascular remodeling; extracellular matrix degradation; inflammatory signaling pathways; molecular targets for therapy; autophagy; macrophage; inflammation; immune cell regulation; age-related diseases; therapeutic implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health
edited by and Andrea Corsello
submission deadline 20 Sep 2026 | 5 articles | Viewed by 10906 | Submission Open
Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome
(This special issue belongs to the Section Molecular Biology)
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