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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Perspectives in 3D Bioprinting
edited by Pamela Mozetic and
submission deadline 30 Nov 2025 | Viewed by 404 | Submission Open
Keywords: 3D bioprinting; regenerative medicine; pluripotent stem cells; disease modeling; precision medicine
(This special issue belongs to the Section Materials Science)
Genetic Considerations in the Evolving Treatment Landscape of Hormone-Sensitive and Hormone-Resistant Prostate Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 399 | Submission Open
Keywords: prostate cancer; hormone-sensitive prostate cancer; HSPC; hormone-resistant prostate cancer; HRPC; metastasis; androgen deprivation therapy; docetaxel; androgen receptor axis-targeted therapy agents; ARAT; abiraterone; enzalutamide; apalutamide; talazoparib; genetic; biomarker; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Genomic and Proteomic Advances in Tracking Antibiotic Resistance Evolution
edited by
submission deadline 30 Nov 2025 | Viewed by 346 | Submission Open
Keywords: antibiotic resistance; genomic; proteomic; one health
(This special issue belongs to the Section Molecular Biology)
Molecular Markers and Genetic Diversity in Plants
edited by Eugenija Kupčinskienė
submission deadline 30 Nov 2025 | Viewed by 318 | Submission Open
Keywords: plant populations; genetic diversity; molecular diversity; invasion; invasive alien species; pollution; climate change; habitat; conservation; endangered and rare species; DNA markers; molecular markers; sequencing
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products on Neurological Diseases, Neuroinflammation and Neuropathic Pain
edited by Karin C. Calaza
submission deadline 30 Nov 2025 | Viewed by 293 | Submission Open
Keywords: natural products; neurological diseases; neuroinflammation; neuropathic pain; neuroprotection; anti-inflammatory compounds; pain modulation; plant-based therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Brain Stroke Across the Lifespan: Mechanisms, Models, Translational Advances and Impacts Beyond the Brain
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 282 | Submission Open
Keywords: stroke; brain; cerebral injury; post-stroke recovery; systemic physiology; models; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Research Progress on Photosensitizers and Photodynamic Therapy
edited by
submission deadline 30 Nov 2025 | Viewed by 266 | Submission Open
Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms
(This special issue belongs to the Section Biochemistry)
Vitamin D and New Vitamin D Analogs
edited by
submission deadline 30 Nov 2025 | Viewed by 249 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D analogs; synthesis; clinical applications; cancer; anti-proliferation; therapeutic target
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Research on Glycosylation
edited by
submission deadline 30 Nov 2025 | Viewed by 247 | Submission Open
Keywords: protein glycosylation; protein folding; cell signaling; immune regulation; glycoproteins
(This special issue belongs to the Section Biochemistry)
Stem Cell and Epigenetic Regulation in Regenerative Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 228 | Submission Open
Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell– environment interactions; conditioned medium; secreted factors; epigenetic modification
(This special issue belongs to the Section Molecular Biology)
Strategies and Molecular Mechanisms to Enhance Outcomes in Orthobiologics
edited by Leonardo Oliveira
submission deadline 30 Nov 2025 | Viewed by 225 | Submission Open
Keywords: platelet-rich plasma; adipose-derived stem cells; microfragmented fat; nutrition; exercise; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lectins: Structural Diversity, Molecular Recognition and Emerging Applications submission deadline 30 Nov 2025 | Viewed by 222 | Submission Open
Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications
(This special issue belongs to the Section Biochemistry)
The Application of Biomaterials in Bone Tissue Repair and Regeneration, 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 220 | Submission Open
Keywords: allograft; autograft; autologous bone; bone; graft materials; mineral substitutes; regeneration
(This special issue belongs to the Section Materials Science)
Biomaterials for Bone Treatment, Replacement and Regeneration: Focus on Regeneration and Inflammation
edited by
submission deadline 30 Nov 2025 | Viewed by 217 | Submission Open
Keywords: biomaterials  ; bone substitute  ; inflammation  ; foreign body response  ; bone regeneration
(This special issue belongs to the Section Materials Science)
Molecular Research on Ataxia submission deadline 30 Nov 2025 | Viewed by 211 | Submission Open
Keywords: ataxia; molecular mechanisms; repeat expansion disorders; gene discovery; biomarkers; RNA biology; protein aggregation; epigenetics; gene therapy; neurodegeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
DNA Repair, Genome Stability and Diseases
edited by Melike Caglayan
submission deadline 30 Nov 2025 | Viewed by 208 | Submission Open
Keywords: DNA damage; DNA repair; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Design and Engineering of Carbon-Based Materials for Environmental Remediation and Bioenergy
edited by Hilda Elizabeth Reynel-Ávila
submission deadline 30 Nov 2025 | Viewed by 207 | Submission Open
Keywords: adsorption; catalysis; functionalization; molecular design; environmental; sustainable energy; tailoring
(This special issue belongs to the Section Materials Science)
Plant Extracts: Molecular Insights and Functional Potential
edited by Abdelaziz Yasri
submission deadline 30 Nov 2025 | Viewed by 205 | Submission Open
Keywords: plant extract; phytochemistry; plant secondary metabolites; plant extraction techniques; product valorization
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management
edited by Alberto Palazzuoli, and
submission deadline 30 Nov 2025 | Viewed by 202 | Submission Open
Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Pediatric Neuromuscular Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 201 | Submission Open
Keywords: pediatric neuromuscular disorders; gene therapy; biomarkers; molecular pathophysiology; muscular dystrophy; motor neuron disease; translational medicine; neuromuscular therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Autoimmune Diseases and Rheumatology
edited by
submission deadline 30 Nov 2025 | Viewed by 195 | Submission Open
Keywords: rheumatology; molecular immunology; autoimmune diseases; biomarkers; transcriptomics; proteomics; epigenetics; single-cell analysis; cytokine signaling; precision medicine; exosomes; microRNA; immune metabolism; fibroblast activation; translational research
(This special issue belongs to the Section Molecular Immunology)
Kidney Diseases: Molecular Research and Novel Therapies
edited by Niels Olsen Saraiva Camara
submission deadline 30 Nov 2025 | Viewed by 187 | Submission Open
Keywords: kidney disease; immunology and inflammation; zebrafish models; therapeutic targets; modern-era drivers of renal pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation: Emerging Insights and Advances in Drug Development submission deadline 30 Nov 2025 | Viewed by 184 | Submission Open
Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’ s disease; Alzheimer’ s disease; multiple scleroris; stroke
(This special issue belongs to the Section Molecular Neurobiology)
Gynecologic Oncology: Tumor Microenvironment and Novel Therapeutics submission deadline 30 Nov 2025 | Viewed by 181 | Submission Open
Keywords: tumor microenvironment; peritoneal-cancer cell interactions; extracellular matrix; ascites; immune cells; cancer-associated fibroblasts; immunotherapy; novel therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Antimicrobial Nanoparticles: Mechanisms, Applications, and Future Directions submission deadline 30 Nov 2025 | Viewed by 179 | Submission Open
Keywords: antimicrobial activity; nanoparticles; biofilm nano-modulators; antibiotic resistence; wastewater treatment; preservative properties of nanoparticles
(This special issue belongs to the Section Molecular Microbiology)
Rheumatoid Arthritis: From Molecular Mechanism to Emerging Therapeutic Target
edited by Elisa Gremese and Costantino Pitzalis
submission deadline 30 Nov 2025 | Viewed by 179 | Submission Open
Keywords: rheumatoid arthritis; molecular mechanisms; emerging therapeutic targets; precision medicine; synovial tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Kidney Disease: Molecular Insights and Emerging Therapies
edited by
submission deadline 30 Nov 2025 | Viewed by 176 | Submission Open
Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Tau Protein Research submission deadline 30 Nov 2025 | Viewed by 173 | Submission Open
Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’ s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Lipopolysaccharides submission deadline 30 Nov 2025 | Viewed by 170 | Submission Open
Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases
(This special issue belongs to the Section Molecular Biology)
Combined and Mixture Exposure Toxicology of Cancer
edited by and Quentin Felty
submission deadline 30 Nov 2025 | Viewed by 169 | Submission Open
Keywords: combined exposure; mixture exposure; toxicology of cancer; omics of cancer; AI in carcinogenesis; machine learning use in cancer; cancer biomarkers; pollutants of cancer; agrochemicals; endocrine-disruptive chemicals
(This special issue belongs to the Section Molecular Oncology)
Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience submission deadline 30 Nov 2025 | Viewed by 167 | Submission Open
Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases
(This special issue belongs to the Section Molecular Biology)
Predict to Treat: Prognostic and Predictive Biomarkers in Breast Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 167 | Submission Open
Keywords: breast cancer; predictive biomarkers; prognostic biomarkers; precision oncology; treatment resistance; gene expression; liquid biopsy; immune microenvironment; targeted therapy; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Horizons in Antiviral and Antibacterial Agent Discovery submission deadline 30 Nov 2025 | 1 articles | Viewed by 165 | Submission Open
Keywords: antimicrobial resistance; multidrug-resistant infections; new antimicrobial drug development; natural and synthetic an-timicrobial agents; drug repurposing
(This special issue belongs to the Section Molecular Microbiology)
Stress Signaling and Horticultural Crops Quality Control
edited by and
submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open
Keywords: stress tolerance; molecular mechanisms; quality traits; redox regulation; postharvest physiology; signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Small Molecules in Tissue Repair and Regeneration submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: small molecules; organ and tissue regeneration; development; aging
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias
edited by Joan-Lluís Vives-Corrons
submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: anemia; red blood cell erythropoiesis; membranopathies  ; erythro enzymopathies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Diabetes and Its Complications
edited by
submission deadline 30 Nov 2025 | Viewed by 162 | Submission Open
Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Nematodes Management
edited by
submission deadline 30 Nov 2025 | Viewed by 162 | Submission Open
Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation
(This special issue belongs to the Section Molecular Biology)
Breast Cancer and Molecular-Based Treatments
edited by
submission deadline 30 Nov 2025 | Viewed by 157 | Submission Open
Keywords: breast cancer; immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Non-Coding RNAs as Key Regulators in Human Disease Processes
edited by
submission deadline 30 Nov 2025 | Viewed by 156 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolomics in Physiology and Disease: Advances and Perspectives
edited by
submission deadline 30 Nov 2025 | Viewed by 155 | Submission Open
Keywords: metabolomics; disease biomarkers; data integration; bioinformatics; mass spectrometry; personalized medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Adhesion, Invasion, and Metastasis in Cancer Progression submission deadline 30 Nov 2025 | Viewed by 154 | Submission Open
Keywords: cancer metastasis; cellular adhesion; invasion and migration; noncoding RNAs; EMT; Wnt/β -catenin signalling; tumour microenvironment; biomarkers; AI-driven metastasis prediction
(This special issue belongs to the Section Molecular Oncology)
Cellular and Molecular Mechanisms in Diabetes Therapies
edited by
submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open
Keywords: diabetes; β -cells; insulin signaling; inflammation; metabolic pathways; molecular mechanisms; stem cell therapy; gene therapy; oxidative stress; microbiota; immune modulation; epigenetics; regenerative medicine; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Signal Transduction Pathways: From Molecular Mechanisms to Therapeutic Targets
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 150 | Submission Open
Keywords: signal transduction; molecular mechanism; cell signaling; disease pathways; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Pathogenesis of Pulmonary Arterial Hypertension: Differences in Molecular Mechanisms Between Neonatal and Adult Pulmonary Hypertension
edited by Germán Ebensperger
submission deadline 30 Nov 2025 | Viewed by 150 | Submission Open
Keywords: pulmonary arterial hypertension; newborn; cardiovascular perinatal transition; vascular remodeling; vascular reactivity; vascular inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Genetics and Precision Breeding of Tomato
edited by Younghoon Park
submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open
Keywords: climate change; gene editing; genomic selection; flavor; functional compounds; molecular marker; omics; precision breeding; Solanum lycopersicum; tomato
(This special issue belongs to the Section Molecular Plant Sciences)
New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 142 | Submission Open
Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Pathology and Treatment of Hepatocellular Carcinoma
edited by
submission deadline 30 Nov 2025 | Viewed by 140 | Submission Open
Keywords: hepatocellular carcinoma; cholangiocarcinoma; angiosarcoma; metastases; biomarkers; immunohistochemistry; genetics; clinical trial
(This special issue belongs to the Section Molecular Oncology)
Neurobiology and Psychopharmacology of Mood Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 139 | Submission Open
Keywords: mood disorders; psychopharmacology; neurobiology; molecular mechanisms; biomarkers; translational psychiatry; neuroinflammation; signal transduction; animal models; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action
edited by
submission deadline 30 Nov 2025 | Viewed by 138 | Submission Open
Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships
(This special issue belongs to the Section Molecular Biology)
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