Multi-Omics Perspectives on Psychiatric Disorders: From Molecular Mechanisms to Clinical Translation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 238
Editors
Interests: neurology; neuroscience; stroke; neurodegenerative diseases; neuroinflammation; aging; translational medicine
Interests: psychiatry; neuroscience; mental health; mood disorders; psychotic disorders; stroke; neurodegenerative diseases; aging; translational medicine
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue of the International Journal of Molecular Sciences, entitled “Multi-Omics Perspectives on Psychiatric Disorders: From Molecular Mechanisms to Clinical Translation”.
Psychiatric disorders represent a major global health burden and arise from complex interactions between genetic vulnerability, molecular dysregulation, environmental influences, and neurobiological alterations. Recent advances in high-throughput technologies, including genomics, transcriptomics, epigenomics, proteomics, metabolomics, and integrative multi-omics approaches, are transforming our understanding of the molecular architecture underlying mental health and disease.
This Special Issue aims to provide a comprehensive platform for cutting-edge research exploring the molecular mechanisms and biological networks implicated in psychiatric conditions. We seek contributions that bridge basic molecular discoveries, experimental model systems, and clinical translational relevance, fostering a deeper understanding of disease pathogenesis and novel therapeutic opportunities. Topics of interest include, but are not limited to, the following: genomic, transcriptomic, epigenomic, proteomic, and metabolomic signatures in psychiatric disorders; multi-omics data integration and systems biology approaches in psychiatry; molecular mechanisms of neuroinflammation, synaptic dysfunction, neuroplasticity, and neurodegeneration from animal models, organoids, and in vitro experimental systems; biomarker discovery for diagnosis, prognosis, and treatment response; gene–environment interactions and stress-related molecular pathways; pharmacogenomics and personalized medicine in psychiatry; translational studies linking molecular findings with clinical phenotypes; AI and computational approaches applied to psychiatric multi-omics datasets.
We welcome original research articles, systematic reviews, narrative reviews, and methodological papers that advance molecular psychiatry and contribute to the development of precision approaches for mental health care.
This Special Issue aims to bring together interdisciplinary contributions from molecular biologists, neuroscientists, psychiatrists, geneticists, bioinformaticians, and clinician–scientists to shape a more integrated and biologically grounded understanding of psychiatric disorders.
We look forward to receiving your contributions.
Prof. Dr. Veronica Sfredel
Guest Editor
Dr. Madalina Iuliana Mușat
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- molecular psychiatry
- psychiatric multi-omics
- neurobiological pathways
- psychiatric biomarkers
- gene–environment interactions
- translational psychiatry
- computational psychiatry
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