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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment: 2nd Edition

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Aug 2026 | 8 articles | Viewed by 62673 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid–gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Aug 2026 | 4 articles | Viewed by 52574 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology

edited by

Kiminobu Sugaya

submission deadline 20 Aug 2026 | 20 articles | Viewed by 44825 | Submission Open

Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics, proteomics, transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Oncology

edited by

Peter J. K. Kuppen

submission deadline 20 Aug 2026 | 21 articles | Viewed by 37552 | Submission Open

Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Aug 2026 | 4 articles | Viewed by 24359 | Submission Open

Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals

edited by

Maurizio Battino

submission deadline 20 Aug 2026 | 11 articles | Viewed by 21412 | Submission Open

Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Aug 2026 | 7 articles | Viewed by 20806 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 20 Aug 2026 | 11 articles | Viewed by 19338 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 20 Aug 2026 | 10 articles | Viewed by 18547 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Aug 2026 | 7 articles | Viewed by 18448 | Submission Open

Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Aug 2026 | 2 articles | Viewed by 17674 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Metals and Metal Ions in Human Health, Diseases, and Environment

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 20 Aug 2026 | 7 articles | Viewed by 17522 | Submission Open

Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Informatics

edited by

M. Natália D.S. Cordeiro

and

Giulio Vistoli

submission deadline 20 Aug 2026 | 14 articles | Viewed by 15766 | Submission Open

Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering

(This special issue belongs to the Section Molecular Informatics)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 20 Aug 2026 | 6 articles | Viewed by 15505 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition

edited by

Ilavenil Soundharrajan

submission deadline 20 Aug 2026 | 8 articles | Viewed by 15192 | Submission Open

Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant–Microbe Interactions: 2nd Edition

edited by Jian Jin

submission deadline 20 Aug 2026 | 6 articles | Viewed by 14574 | Submission Open

Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes

(This special issue belongs to the Section Molecular Plant Sciences)

Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications

edited by Kaiqun Ren and Hui Zou

submission deadline 20 Aug 2026 | 4 articles | Viewed by 13941 | Submission Open

Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Cancer Genomics

edited by

Yoshihito Kano

submission deadline 20 Aug 2026 | 8 articles | Viewed by 13565 | Submission Open

Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery

(This special issue belongs to the Section Molecular Biology)

New Insights into Plant Stress

edited by

Pandiyan Muthuramalingam

Subramani Pandian

and

Hyunsuk Shin

submission deadline 20 Aug 2026 | 5 articles | Viewed by 13157 | Submission Open

Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 20 Aug 2026 | 2 articles | Viewed by 12941 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Aug 2026 | 7 articles | Viewed by 12914 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Aug 2026 | 8 articles | Viewed by 12506 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Aug 2026 | 6 articles | Viewed by 12436 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition

edited by

Kyriacos N. Felekkis

and

Christos Papaneophytou

submission deadline 20 Aug 2026 | 7 articles | Viewed by 12283 | Submission Open

Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers

(This special issue belongs to the Section Biochemistry)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Aug 2026 | 8 articles | Viewed by 11983 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Plant Molecular Regulatory Networks and Stress Responses

edited by

Xiujun Zhang

submission deadline 20 Aug 2026 | 5 articles | Viewed by 11971 | Submission Open

Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Aug 2026 | 7 articles | Viewed by 11603 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 20 Aug 2026 | 2 articles | Viewed by 11281 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions

edited by

Andrius Sakalauskas

submission deadline 20 Aug 2026 | 4 articles | Viewed by 10923 | Submission Open

Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Brain Cancers: Second Edition

edited by

Monika Gudowska-Sawczuk

and

Karolina Orywal

submission deadline 20 Aug 2026 | 1 articles | Viewed by 10748 | Submission Open

Keywords: brain tumors; malignant brain tumor; advanced cancer biology

(This special issue belongs to the Section Molecular Oncology)

Plant Stress Biology

edited by

Rui Li

submission deadline 20 Aug 2026 | 10 articles | Viewed by 10486 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Antimicrobial Nanomaterials 2.0

edited by

Irena Maliszewska

submission deadline 20 Aug 2026 | 4 articles | Viewed by 10351 | Submission Open

Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents

(This special issue belongs to the Section Molecular Nanoscience)

Nutraceuticals and Healthy Aging: Molecular Mechanisms and Therapeutic Perspectives

edited by

Francesca Uberti

submission deadline 20 Aug 2026 | 4 articles | Viewed by 10197 | Submission Open

Keywords: molecular mechanisms of the action of nutraceuticals on cellular aging; nutraceuticals and neuroprotection; effects of nutraceuticals on skin aging; nutraceuticals in the prevention or management of age-related metabolic diseases; interaction between nutraceuticals and gut microbiota in aging; nutraceuticals in bone and joint health; role of nutraceuticals in menopausal management; impact of nutraceuticals on BPH and prostate health; multi-target approaches of nutraceuticals in healthy aging; innovative nutraceutical delivery and formulation strategies to increase bioavailability; clinical and preclinical studies of nutraceuticals in the elderly population

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Post-Mortem Toxicology

edited by

Rafał Skowronek

submission deadline 20 Aug 2026 | 3 articles | Viewed by 9787 | Submission Open

Keywords: post-mortem toxicology; fatal poisoning; new psychoactive substances; opioids; analytical methods; interpretation of test results

(This special issue belongs to the Section Molecular Toxicology)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 20 Aug 2026 | 8 articles | Viewed by 9423 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 20 Aug 2026 | 2 articles | Viewed by 9400 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 20 Aug 2026 | 7 articles | Viewed by 9363 | Submission Open

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Aug 2026 | 4 articles | Viewed by 9168 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases

edited by Eisuke F. Sato

submission deadline 20 Aug 2026 | 3 articles | Viewed by 8630 | Submission Open

Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Seed Development and Germination

edited by

Sławomir Borek

Łukasz Wojtyla

and

Małgorzata Garnczarska

submission deadline 20 Aug 2026 | 5 articles | Viewed by 8507 | Submission Open

Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress

(This special issue belongs to the Section Molecular Plant Sciences)

Antimicrobial Nanomaterials: Approaches, Strategies and Applications

edited by

Andrea Bernardos

submission deadline 20 Aug 2026 | 3 articles | Viewed by 8477 | Submission Open

Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles

(This special issue belongs to the Section Materials Science)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Aug 2026 | 4 articles | Viewed by 8301 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Obesity: From Cellular Mechanism to Potential Molecular Therapies

edited by

Veronica Jimenez

submission deadline 20 Aug 2026 | 4 articles | Viewed by 8258 | Submission Open

Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer

(This special issue belongs to the Section Molecular Biology)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Aug 2026 | 1 articles | Viewed by 8126 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Molecular Imaging for Cancer Theranostics

edited by

Hak Soo Choi

and Kai Bao

submission deadline 20 Aug 2026 | 2 articles | Viewed by 7925 | Submission Open

Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion Channels as Therapeutic Target: Drug Design and Pharmacological Investigation (3rd Edition)

edited by

Gabriella Guerrini

submission deadline 20 Aug 2026 | 7 articles | Viewed by 7659 | Submission Open

Keywords: LGIC; voltage-gated ion channel; other ion channels; biological studies; molecular modeling; drug design; synthesis

(This special issue belongs to the Section Molecular Pharmacology)

Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition

edited by

Jyotshna Kanungo

submission deadline 20 Aug 2026 | 5 articles | Viewed by 7565 | Submission Open

Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders

(This special issue belongs to the Section Molecular Biology)

New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside

edited by Irina Ivanova Stoyanova

submission deadline 20 Aug 2026 | 4 articles | Viewed by 7554 | Submission Open

Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma

(This special issue belongs to the Section Molecular Neurobiology)

Innovative Strategies in the Design and Development of Anticancer Agents

edited by Sanjay Kumar

submission deadline 20 Aug 2026 | 4 articles | Viewed by 6944 | Submission Open

Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release

(This special issue belongs to the Section Molecular Pharmacology)

Fungal Genetics and Functional Genomics Research

edited by

Yuqi Qin

and

Jian Zhao

submission deadline 20 Aug 2026 | 7 articles | Viewed by 6927 | Submission Open

Keywords: enzymes; fungal genetics; fungi; gene editing; regulation; secondary metabolites; synthetic biology; transcription

(This special issue belongs to the Section Molecular Genetics and Genomics)

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