International Journal of Molecular Sciences

Advanced Therapy for Human Haemoglobinopathy

edited by Alex Felice and

submission deadline 30 Jan 2026 | Viewed by 116 | Submission Open

Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances of Osteomuscolar Conditions

edited by

Nicola Veronese

submission deadline 30 Jan 2026 | Viewed by 113 | Submission Open

Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 30 Jan 2026 | Viewed by 106 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Brain Cancers: Second Edition

edited by

Monika Gudowska-Sawczuk

and

Karolina Orywal

submission deadline 30 Jan 2026 | Viewed by 104 | Submission Open

Keywords: brain tumors; malignant brain tumor; advanced cancer biology

(This special issue belongs to the Section Molecular Oncology)

Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 30 Jan 2026 | Viewed by 93 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 30 Jan 2026 | Viewed by 92 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Tumor Viruses: Infection, Carcinogenesis, and Treatment

edited by

Sherif T.S. Hassan

submission deadline 30 Jan 2026 | Viewed by 90 | Submission Open

Keywords: tumor viruses; viral oncogenesis; EBV; HPV; KSHV; HBV; HCV; HTLV-1; and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies

(This special issue belongs to the Section Molecular Microbiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Toxicology

edited by

Marco E. M. Peluso

submission deadline 30 Jan 2026 | Viewed by 84 | Submission Open

Keywords: molecular toxicology; biomarkers; mechanisms of toxicity; xenobiotics; cancer diagnosis

(This special issue belongs to the Section Molecular Toxicology)

Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management

edited by

James Alan Bourgeois

submission deadline 30 Jan 2026 | Viewed by 83 | Submission Open

Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Neural Signaling: The Perspective of Molecular Genetics

edited by

Chunlai Wu

submission deadline 30 Jan 2026 | Viewed by 80 | Submission Open

Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 30 Jan 2026 | Viewed by 79 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

New Advances in Environmental Carcinogenesis

edited by Grażyna Gromadzka

submission deadline 30 Jan 2026 | Viewed by 70 | Submission Open

Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment

(This special issue belongs to the Section Molecular Toxicology)

The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development

edited by

Iwona Morkunas

submission deadline 30 Jan 2026 | Viewed by 64 | Submission Open

Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Roles of Epithelial and Endothelial Cells

edited by

Lucie Germain

and

Stéphanie Proulx

submission deadline 31 Jan 2026 | 9 articles | Viewed by 17478 | Submission Open

Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier

(This special issue belongs to the Section Biochemistry)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6999 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019

edited by

Sandor G. Vari

submission deadline 31 Jan 2026 | 6 articles | Viewed by 5926 | Submission Open

Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2970 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition

edited by

Ilavenil Soundharrajan

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2799 | Submission Open

Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2536 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2299 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Cellular Mechanism in Neuroinflammation Research

edited by

Robert P. Ostrowski

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2134 | Submission Open

Keywords: non-coding RNA; nucleic acids; inflammatory cells; inflammatory mediators; neurotransmitters; neuroinflammation; immune cells; neurodegenerative diseases; cerebrovascular diseases; brain tumors

(This special issue belongs to the Section Molecular Neurobiology)

Oxidative and Redox Signalling in Neurological Diseases

edited by

Malamati Kourti

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1852 | Submission Open

Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research into Chronic Heart Failure

edited by

Velia Cassano

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1817 | Submission Open

Keywords: heart failure; oxidative stress; cardiac remodeling; cardiomyopathy; proteomic; molecular science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibody Engineering and Therapeutic Applications

edited by

Yong-Seok Heo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1722 | Submission Open

Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action

(This special issue belongs to the Section Molecular Pharmacology)

Innovative Strategies and Molecular Insights Into Wound Healing

edited by

Cheong Hoon Seo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1618 | Submission Open

Keywords: wound healing; tissue regeneration; hypertrophic scar; biomaterials; stem cell therapy; gene therapy; exosomes; burn rehabilitation; inflammation; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutraceuticals and Healthy Aging: Molecular Mechanisms and Therapeutic Perspectives

edited by

Francesca Uberti

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1432 | Submission Open

Keywords: molecular mechanisms of the action of nutraceuticals on cellular aging; nutraceuticals and neuroprotection; effects of nutraceuticals on skin aging; nutraceuticals in the prevention or management of age-related metabolic diseases; interaction between nutraceuticals and gut microbiota in aging; nutraceuticals in bone and joint health; role of nutraceuticals in menopausal management; impact of nutraceuticals on BPH and prostate health; multi-target approaches of nutraceuticals in healthy aging; innovative nutraceutical delivery and formulation strategies to increase bioavailability; clinical and preclinical studies of nutraceuticals in the elderly population

(This special issue belongs to the Section Bioactives and Nutraceuticals)

RNA-Based Regulation in Human Health and Disease

edited by

Alfredo Ciccodicola

and

Sudharshan Setra Janardhana Shetty

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1375 | Submission Open

Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery

(This special issue belongs to the Section Molecular Genetics and Genomics)

25th Anniversary of IJMS: Updates and Advances in Molecular Biology

edited by

Irmgard Tegeder

,

Antonio Ieni

and

Costantino Balestra

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1274 | Submission Open

Keywords: next-generation sequencing (NGS); CRISPR-Cas9; liquid biopsy; molecular diagnostics; personalized medicine; genome-wide association studies (GWAS)

(This special issue belongs to the Section Molecular Biology)

Neuropharmacological Innovations in Treating Neurodegenerative Diseases

edited by

Gabriela Cioca

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1252 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; targeted drug delivery; blood– brain barrier permeability; synaptic modulation; neuroprotective agents; disease-modifying therapies; molecular mechanisms of neurodegeneration; innovative drug targets; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Voltage-Gating and Modulation in Ion Channels

edited by Joao Carvalho de Souza

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1193 | Submission Open

Keywords: voltage-gated ion channels; voltage sensing; voltage sensor coupling; new modulators; ion channel modulation; cell excitability

(This special issue belongs to the Section Molecular Biophysics)

New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside

edited by Irina Ivanova Stoyanova

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1128 | Submission Open

Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Genetics and Genomics of Aquatic Crustaceans

edited by

Xianhong Meng

, Falin Zhou and Lingbo Ma

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1057 | Submission Open

Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives

edited by

Luca Mastorino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1024 | Submission Open

Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype

(This special issue belongs to the Section Molecular Immunology)

Ion Channels as Therapeutic Target: Drug Design and Pharmacological Investigation (3rd Edition)

edited by

Gabriella Guerrini

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1022 | Submission Open

Keywords: LGIC; voltage-gated ion channel; other ion channels; biological studies; molecular modeling; drug design; synthesis

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Toxicity Induced by Engineered Nanomaterials

edited by

Shan Zienolddiny-Narui

submission deadline 31 Jan 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: toxicity; occupational health; engineered nanomaterials; physical– chemical characteristics; toxicokinetic; toxicodynamic; in vivo; NAMs; NGRA (new-generation risk assessment)

(This special issue belongs to the Section Molecular Toxicology)

Molecular Insights into Pancreatic Diseases

edited by

Wasif Saif

submission deadline 31 Jan 2026 | 1 articles | Viewed by 940 | Submission Open

Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Basic and Translational Research in Colorectal Cancer

edited by

Gina Gheorghe

submission deadline 31 Jan 2026 | 1 articles | Viewed by 938 | Submission Open

Keywords: colorectal cancer; diagnostic and prognostic biomarkers; genetic and epigenetic alterations; MMR/MSI; cytokine profiling; inflammatory mediators; gut microbiota; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Target and Anti-Cancer Therapies

edited by Laura Denisa Dragu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 928 | Submission Open

Keywords: cancer; conventional therapy; targeted therapy; immunotherapy; natural compounds; combinatorial therapy; molecular target; molecular mechanism; drug design; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Proliferation and Differentiation in Cancer

edited by

Sérgio Paulo Bydlowski

submission deadline 31 Jan 2026 | 1 articles | Viewed by 913 | Submission Open

Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Radiation Oncology: Mechanisms, Immunotherapy and Innovation

edited by Jasna But-Hadžić

submission deadline 31 Jan 2026 | 1 articles | Viewed by 912 | Submission Open

Keywords: molecular radiation oncology; DNA damage response; immunoradiotherapy; radiosensitization; tumor– immune interactions; radiogenomics; predictive biomarkers; combination therapies; translational radiobiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress in Plants: Physiological and Molecular Responses

edited by Edyta Zdunek-Zastocka

submission deadline 31 Jan 2026 | 1 articles | Viewed by 889 | Submission Open

Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Epilepsy: Exploring the Molecular Mechanisms and Potential Medications

edited by

Motohiro Okada

submission deadline 31 Jan 2026 | 1 articles | Viewed by 805 | Submission Open

Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Strategies Targeting Solid Tumors and the Tumor Microenvironment

edited by Emanuela Berrino and

Giuseppina Catanzaro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 786 | Submission Open

Keywords: cancer; tumor microenvironment; medicinal chemistry; drug design; structure– activity relationships; nanotechnologies; antibody– drug conjugates; non-coding RNAs; epigenetic

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Functional Nanomaterials

edited by

Łukasz Laskowski

submission deadline 31 Jan 2026 | 1 articles | Viewed by 732 | Submission Open

Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms of Plant Virus Infection, Resistance and Control

edited by

Carl Spetz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 731 | Submission Open

Keywords: plant virus; host– pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Synthesis, Biosynthesis and Implications of Chalcones

edited by

Pal Perjesi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: chalcones; biosynthesis; biochemistry

(This special issue belongs to the Section Biochemistry)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Jan 2026 | Viewed by 570 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies

edited by

Emanuela Pessolano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 568 | Submission Open

Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

HIV Infection, Pathogenesis and Treatment

edited by

Mudit Tyagi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 558 | Submission Open

Keywords: HIV Infection; HIV; host immune responses; pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Protein–Ligand Interactions

edited by

Qiaomei Sun

submission deadline 31 Jan 2026 | 1 articles | Viewed by 557 | Submission Open

Keywords: interaction; protein– ligand; computer simulation; docking; molecular simulation

(This special issue belongs to the Section Biochemistry)

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