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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Glia: New Insights into Neurobiology and Therapeutic Potential

edited by María de los Ángeles García-Robles

submission deadline 28 Feb 2026 | Viewed by 58 | Submission Open

Keywords: glial metabolism; astrocytes; microglia; oligodendrocytes; tanycytes; obesity; diabetes; metabolic disorders; neurogenesis; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Interactions Between Nanoparticles and Biomolecules

edited by

Zhengwei Huang

submission deadline 28 Feb 2026 | Viewed by 57 | Submission Open

Keywords: nanoparticle– biomolecule interaction; nanomedicine; bio-corona; targeting; in vivo fate

(This special issue belongs to the Section Molecular Nanoscience)

The Pivotal Role of Endothelial Cells in Vascular Homeostasis and Immune Regulation

edited by

Ilenia Calcaterra

submission deadline 28 Feb 2026 | Viewed by 57 | Submission Open

Keywords: endothelial cells; vascular homeostasis; immune regulation; leukocyte trafficking; endothelial barrier function; mechanotransduction; glycocalyx; endothelial dysfunction; atherosclerosis; thrombosis

(This special issue belongs to the Section Molecular Immunology)

Next-Generation Drug Development: Novel Modalities, AI Modeling, and Biomarkers

edited by

Chun-Yi Wu

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: pharmacokinetics; PK/PD modeling; biologics; antibody– drug conjugates (ADCs); biomarkers; artificial intelligence; novel therapeutic modalities; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Kidney Diseases: Molecular Pathogenesis and Therapeutic Strategies—3rd Edition

edited by

Gábor Kökény

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: kidney fibrosis; chronic kidney disease; gene expression; acute kidney injury; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Amino Acid and Sugar Metabolism in Disease

edited by V. Tkach

submission deadline 28 Feb 2026 | Viewed by 55 | Submission Open

Keywords: metabolic diseases; metabolic disturbances; carbohydrate metabolism; aminoacid metabolism; artificial sweeteners; metabolic path alterations

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Xenobiotic Toxicity: From Transcriptional Regulation to Reproductive and Behavioural Impacts

edited by Sylwia Swigonska

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: xenobiotic interactions; molecular mechanisms of toxicity; reproductive toxicology; early biomarkers; emerging contaminants; neurobehavioral toxicity; microbiota– xenobiotic interactions; biomolecular responses; environmental health; molecular toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Handshakes: Engineering Protein–Ligand Interfaces for Precision Drug Design

edited by Tarun Jairaj Narwani

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: structure-based drug design (SBDD); AI-driven drug discovery; protein– ligand dynamics; molecular interface engineering; structural biology; chemical biology; allosteric modulation; undruggable targets and drug resistance

(This special issue belongs to the Section Biochemistry)

Stem Cell Research in Urological, Hepatological, and Ophthalmological Disorders

edited by Yuanyuan Zhang

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); exosomes; tissue regeneration; urinary incontinence; kidney dysfunction; ocular disorders; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Viral and Host Targets to Fight RNA Viruses: 2nd Edition

edited by

Tommaso Felicetti

submission deadline 28 Feb 2026 | Viewed by 51 | Submission Open

Keywords: RNA viruses; antiviral agents; medicinal chemistry; direct-acting antivirals; host-targeting agents; drug design

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Peptides: Discovery, Synthesis, and Therapeutic Applications

edited by

Chuan-Mu Chen

submission deadline 28 Feb 2026 | Viewed by 50 | Submission Open

Keywords: bioactive peptides; functional food-derived peptides; antimicrobial and antiviral peptides; peptide drug design and delivery; anticancer peptides; peptide-based therapeutics; regenerative medicine; immunomodulatory peptides; structure– function relationships; translational peptide research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Diagnostics and Therapeutics of Neurodegenerative Disease

edited by

Romina Combi

submission deadline 28 Feb 2026 | Viewed by 50 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Neurobiology)

T Cell Immunity in Coronavirus Infection: Mechanisms, Dysregulation, and Therapeutic Targets

edited by Jian Zheng

submission deadline 28 Feb 2026 | Viewed by 50 | Submission Open

Keywords: T cell; coronavirus; immune memory; immunopathogenesis; aging

(This special issue belongs to the Section Molecular Immunology)

Advancements in Prognostic and Predictive Biomarkers for Advanced Prostate Cancer

edited by

Daniel Khalaf

submission deadline 28 Feb 2026 | Viewed by 50 | Submission Open

Keywords: biomarkers; predictive biomarkers; prognostic biomarkers; genomic biomarkers; biomarker directed therapy; advanced prostate cancer; metastatic prostate cancer; circulating tumour DNA; precision oncology; systemic therapy

(This special issue belongs to the Section Molecular Oncology)

The Role of Diet and Nutrition in Metabolic Diseases

edited by

Junjie Luo

submission deadline 28 Feb 2026 | Viewed by 49 | Submission Open

Keywords: diet; nutrition; metabolic diseases; molecular mechanisms; nutrigenomics; metabolomics; epigenetics; mitochondrial function; oxidative stress; biomarkers

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nano-Enabled Molecular Strategies Against Oxidative Stress in Human Physiology

edited by

Ali Amer

submission deadline 28 Feb 2026 | Viewed by 48 | Submission Open

Keywords: nanoparticles; oxidative stress; reproductive toxicology; redox signalling pathways; mitochondrial regulation; controlled drug release; antioxidant defence mechanisms; pharmaceutical nanotechnology

(This special issue belongs to the Section Molecular Immunology)

Structure–Property Correlations in Electrocatalysis: Role of Chemistry, Phases, and Morphology

edited by

Dawid Kutyła

submission deadline 28 Feb 2026 | Viewed by 48 | Submission Open

Keywords: electrocatalysis; structure– property correlations; chemical composition; phases; morphology; porous electrodes; high-entropy alloys; molten salts; semiconductors; nanostructures; operando methods; hydrogen/oxygen evolution; CO2 reduction; fuel cells

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Molecular Research of Animal Genetics and Genomics

edited by Congjiao Sun

submission deadline 28 Feb 2026 | 1 articles | Viewed by 44 | Submission Open

Keywords: animal genetics; animal genomics; molecular breeding; genetic improvement; molecular evolution; genomic selection; genome-wide association studies (GWAS); CRISPR; multiomics analysis; animal conservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Synthesis and Activity of Natural Products and Analogues

edited by

Jin-pyo An

submission deadline 28 Feb 2026 | Viewed by 43 | Submission Open

Keywords: natural products; functional food; synthesis; high-resolution mass spectrometry; bioactive compound

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovative Delivery Systems of Natural and Synthetic Active Compounds

edited by

Aleksandra Gostyńska-Stawna

submission deadline 28 Feb 2026 | Viewed by 41 | Submission Open

Keywords: delivery systems; nanocarriers; natural and synthetic compounds; oral and parenteral administration; molecular mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innate Immune Response in Infectious Diseases

edited by

Julia Fischer

submission deadline 28 Feb 2026 | Viewed by 38 | Submission Open

Keywords: innate immunity; metabolism; bacteria; virus; inflammation; mechanism; immune defense

(This special issue belongs to the Section Molecular Immunology)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 1 Mar 2026 | Viewed by 85 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advance on Skin Irritation and Inflammation

edited by Nazgol-Sadat Haddadi

submission deadline 12 Mar 2026 | Viewed by 61 | Submission Open

Keywords: photoimmunology; keratinocyte stress; type I interferon; cutaneous lupus erythematosus; der-matomyositis; monocyte-derived dendritic cells; fibroblast heterogeneity; cytokine– chemokine networks; single-cell and spatial omics; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Natural Products in Health and Diseases

edited by

Katarína Bauerová

submission deadline 15 Mar 2026 | 4 articles | Viewed by 12358 | Submission Open

Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Pharmacology)

Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies

edited by

Masaru Tanaka

submission deadline 20 Mar 2026 | 10 articles | Viewed by 38444 | Submission Open

Keywords: molecular psychiatry; biomarkers; pharmacogenomics; precision medicine; gene-environment Interaction; neuroinflammation; immune modulation; neuroimaging; molecular imaging; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Kynurenic Acid: Emerging Research Advances and Therapeutic Implications

edited by

Piotr Paluszkiewicz

and Monika Turska-Kozłowska

submission deadline 20 Mar 2026 | 8 articles | Viewed by 36643 | Submission Open

Keywords: kynurenic acid; kynurenine pathway; kynurenine; therapeutic use; supply and distribution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes

edited by

Daniela Miricescu

submission deadline 20 Mar 2026 | 11 articles | Viewed by 31216 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease

edited by

Marija Stankovic

submission deadline 20 Mar 2026 | 8 articles | Viewed by 29419 | Submission Open

Keywords: COPD; molecular mechanism; inflammation; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being

edited by

Dasha Mihaylova

and

Aneta Popova

submission deadline 20 Mar 2026 | 7 articles | Viewed by 22781 | Submission Open

Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems

edited by

Ernst Malle

and

János G. Filep

submission deadline 20 Mar 2026 | 6 articles | Viewed by 22150 | Submission Open

Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression

(This special issue belongs to the Section Biochemistry)

Molecular Research and Insights into COVID-19: Third Edition

edited by

Manuela Rizzi

and

Pier Paolo Sainaghi

submission deadline 20 Mar 2026 | 4 articles | Viewed by 22136 | Submission Open

Keywords: SARS-CoV-2; COVID-19; prognostic and diagnostic biomarkers; molecular mechanism of infection; molecular pathophysiology; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Mar 2026 | 6 articles | Viewed by 21165 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Strategies for Neurodegenerative Disease

edited by

Vasileios Papaliagkas

submission deadline 20 Mar 2026 | 4 articles | Viewed by 20949 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; therapy

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Cell Metabolism in Endocrine Diseases

edited by

Antonella Muscella

submission deadline 20 Mar 2026 | 5 articles | Viewed by 19857 | Submission Open

Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Mar 2026 | 7 articles | Viewed by 19717 | Submission Open

Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Human Papillomavirus (HPV) Research

edited by

Jane Shen-Gunther

submission deadline 20 Mar 2026 | 3 articles | Viewed by 18751 | Submission Open

Keywords: human papillomavirus (HPV)/genetics; HPV-associated cancers; HPV cell-free DNA (cfDNA); HPV circulating tumor DNA (ctDNA); HPV circulating tumor cells (CTCs); carcinogenesis/genetics; CRISPR-cas systems/genetics; digital PCR; molecular diagnostics/methods; point-of-care diagnostics/methods; next-generation sequencing/methods; single-cell sequencing/methods; genomics; epigenomics; proteomics; metagenomics; phylogenomics; virus evolution; virus– host interactions; virus integration/genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Perspectives on Wound Healing

edited by

Ermelindo C. Leal

and

Eugenia Carvalho

submission deadline 20 Mar 2026 | 7 articles | Viewed by 18424 | Submission Open

Keywords: chronic wound healing; scarring; biomarkers; inflammation; angiogenesis; infection; extracellular matrix; biomaterials; tissue regeneration; therapeutic targets; innovative therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond Digestion: The Role of Gut Microbiota in Metabolism, Immunity and Brain Function

edited by

Alip Borthakur

submission deadline 20 Mar 2026 | 5 articles | Viewed by 17850 | Submission Open

Keywords: gut dysbiosis; gut microbiota; metabolism

(This special issue belongs to the Section Molecular Immunology)

Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications

edited by Jung-Hyun Lee

submission deadline 20 Mar 2026 | 7 articles | Viewed by 17581 | Submission Open

Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Viral Infections and Immune Responses

edited by

Alessandra Ruggiero

and

Marco Iannetta

submission deadline 20 Mar 2026 | 6 articles | Viewed by 16943 | Submission Open

Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in RNA Drug Development

edited by Hidenori Tani

submission deadline 20 Mar 2026 | 3 articles | Viewed by 16556 | Submission Open

Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration

edited by

Mi Young Lee

submission deadline 20 Mar 2026 | 6 articles | Viewed by 16437 | Submission Open

Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition

edited by

Vincent C. Lombardi

submission deadline 20 Mar 2026 | 4 articles | Viewed by 16299 | Submission Open

Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Molecular Strategies in Biomedicine

edited by

Rui Vitorino

submission deadline 20 Mar 2026 | 4 articles | Viewed by 15573 | Submission Open

Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering

(This special issue belongs to the Section Materials Science)

New Insights in Translational Bioinformatics: Second Edition

edited by

Camelia Quek

submission deadline 20 Mar 2026 | 5 articles | Viewed by 15529 | Submission Open

Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology

(This special issue belongs to the Section Molecular Informatics)

Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition

edited by

Grażyna Nowicka

submission deadline 20 Mar 2026 | 7 articles | Viewed by 14613 | Submission Open

Keywords: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Zoonotic Diseases

edited by

Vishwanath Venketaraman

submission deadline 20 Mar 2026 | 6 articles | Viewed by 14081 | Submission Open

Keywords: mycobacterial diseases; bubonic and pneumonic plague; Q fever; cat scratch disease; Mediterranean fever; HIV; malaria; ADIS; SARS-CoV-2; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Microbiology)

Latest Advances in Reproduction Biology

edited by Clara Malo

submission deadline 20 Mar 2026 | 8 articles | Viewed by 13753 | Submission Open

Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology

(This special issue belongs to the Section Molecular Biology)

Zebrafish as a Model in Human Disease: 3rd Edition

edited by

Andrea Vettori

Nicola Facchinello

and

Marco G. Schiavone

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12972 | Submission Open

Keywords: zebrafish; CRISPR/Cas9; transgenic lines; biosensors; endothelial cells; extracellular matrix; genetic mutant for human disease modeling; xenografts

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Transport of Metabolites Across Biological Membranes

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 20 Mar 2026 | 3 articles | Viewed by 12954 | Submission Open

Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1801-1850 on page 37 of 67.

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