The Pivotal Role of Endothelial Cells in Vascular Homeostasis and Immune Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 19
Special Issue Editor
Interests: gene therapy; rare disease; advanced therapies; gene expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endothelial cells are not passive linings, but dynamic sentinels that integrate hemodynamic, metabolic, and inflammatory cues to maintain vascular homeostasis and orchestrate immune responses. This Special Issue invites contributions that delineate the molecular switches, mechanotransduction (shear stress), glycocalyx integrity, nitric oxide and ROS signaling, and junctional dynamics, governing antithrombotic tone, permeability, and leukocyte trafficking across vascular beds in health and disease. We particularly welcome studies that link endothelial dysfunction to atherosclerosis, thrombosis, vasculitis, sepsis, autoimmune and metabolic disorders, infection, cancer, and vascular aging, as well as work illuminating endothelial–immune crosstalk (adhesion molecules, cytokine networks, antigen presentation), immunometabolism, senescence, and epigenetic reprogramming. Cutting-edge approaches such as single-cell and spatial omics, intravital/high-content imaging, organ-on-chip and microfluidic systems, engineered tissues, systems biology, and AI-assisted analytics are encouraged. Translational submissions identifying biomarkers, therapeutic targets, and barrier-protective or immunomodulatory interventions are of special interest. We welcome original research articles, reviews, brief reports, and methods papers that advance the understanding of endothelial biology at the interface of vascular and immune systems.
Dr. Ilenia Calcaterra
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- endothelial cells
- vascular homeostasis
- immune regulation
- leukocyte trafficking
- endothelial barrier function
- mechanotransduction
- glycocalyx
- endothelial dysfunction
- atherosclerosis
- thrombosis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
