Interactions Between Nanoparticles and Biomolecules
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 14
Special Issue Editor
Interests: inhalable nanomedicines; drug delivery; ferroptosis; biological fate
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recently, nanoparticles have been attracting attention from various fields, such as biomedical, pharmaceutical, chemical, and environmental engineering. For biomedical and pharmaceutical areas, the designed nanoparticles are often referred to as nanomedicines. Widely reported nanomedicines include liposomes, solid lipid nanoparticles, nanomicelles, nanocrystals and metal–organic frameworks. It has been highlighted that these nanomedicines have opened up new avenues for major diseases therapy.
However, compared to the burst of number of relevant publications, the actual clinical translation of nanomedicines is somehow limited. We argue that the limited understanding of the interaction between nanoparticles and biomolecules is one of the major hurdles for clinical translation. Such interaction can be classified into two categories, i.e., (1) designed interaction and (2) non-designed interaction, as follows:
- Designed interaction. Although the nanomedicines are designed to possess certain bio-functions, the detailed interaction mechanisms upon delivery are not clearly known. For example, some nanomedicines are designed to be functionalized with targeting moieties, but the detailed interaction process between the targeting moieties and the targeted biomolecules are generally omitted.
- Non-designed interaction. Nanomedicines will encounter various biomolecules (like proteins, lipids and DNA) in vivo, and unpredictable interaction will take place between the two counterparts. In this scenario, bio-corona will form and significantly alter the pharmacokinetics and pharmacodynamics effects of pristine nanomedicines.
In this Special Issue, we welcome contributions worldwide to address the above issues of designed or non-designed interaction between nanoparticle and biomolecules, so as to boost the gathering of knowledge. Emphases will be put on nanoparticles for biomedical and pharmaceutical uses; but studies on other aspects with direct implications for health sectors may also be considered.
We are looking forward to receiving your exciting work!
Dr. Zhengwei Huang
Guest Editor
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Keywords
- nanoparticle–biomolecule interaction
- nanomedicine
- bio-corona
- targeting
- in vivo fate
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