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Kidney Diseases: Molecular Pathogenesis and Therapeutic Strategies—3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 612

Special Issue Editor

Special Issue Information

Dear Colleagues,

The number of patients with chronic kidney disease is growing exponentially worldwide, affecting up to 14% of the adult population. A wide range of damaging factors (e.g., immunological causes, hypertension, diabetes mellitus, and acute kidney injury) cause inflammation and scarring in the kidney. Due to the high prevalence of chronic kidney disease and its progression to renal failure regardless of etiology, it is important to better understand the underlying pathomechanisms.

Unraveling new molecular pathways that participate in disease progression is essential in order to develop better therapeutic strategies. Key topics cover acute renal failure, chronic kidney diseases, especially diabetic kidney disease and hypertensive nephropathy, glomerulopathies, renal aspects of autoimmune diseases, kidney fibrosis, polycystic kidney disease, obstructive uropathy, and cardiovascular complications related to kidney diseases. This Special Issue aims to present novel experimental and clinical aspects of the pathogenesis and treatment.

Dr. Gábor Kökény
Guest Editor

Manuscript Submission Information

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Keywords

  • kidney fibrosis
  • chronic kidney disease
  • gene expression
  • acute kidney injury
  • inflammation

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Published Papers (1 paper)

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Review

20 pages, 547 KB  
Review
The Impact of Stress on the Functioning and Survival of Transplanted Kidneys—Biological Mechanisms, Clinical Implications, and Therapeutic Perspectives
by Paulina Piechowiak and Katarzyna Aleksandra Lisowska
Int. J. Mol. Sci. 2025, 26(24), 12041; https://doi.org/10.3390/ijms262412041 - 14 Dec 2025
Viewed by 506
Abstract
Stress is well known to affect the immune system. However, in patients suffering from end-stage renal disease (ESRD) who underwent a kidney transplant (KT), the problem of stress appears to still be underestimated. The review aims to discuss the influence of chronic stress [...] Read more.
Stress is well known to affect the immune system. However, in patients suffering from end-stage renal disease (ESRD) who underwent a kidney transplant (KT), the problem of stress appears to still be underestimated. The review aims to discuss the influence of chronic stress on the immune function and the relationship between chronic stress and the fate of a transplanted kidney. Therefore, we analyzed the relevant literature, searching for articles linking chronic stress to kidney transplant. Although the biology of stress is well documented in the literature, its impact on the fate of transplanted kidneys remains poorly understood. We have found only a limited number of studies examining the role of stress in patients after kidney transplantation, especially regarding graft function. However, a few studies have shown that psychological and behavioral interventions appear to reduce perceived stress and improve quality of life among KT patients. Here, we present the Integrated Stress–Immune–Transplant Kidney Model that highlights how stress-related neuroendocrine signals converge with immune and vascular processes to shape chronic immune activation and, ultimately, graft outcomes. It also incorporates behavioral and psychological responses as downstream modulators of the same pathway, rather than parallel or unrelated factors. Addressing this problem in transplant rejection requires an integrative biopsychosocial approach that combines psychological assessment, biological monitoring, and supportive interventions as part of routine post-transplant care. Full article
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