Molecular Advance on Skin Irritation and Inflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 12 March 2026 | Viewed by 42
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammatory skin diseases represent uniquely accessible tissues, useful in decoding how epithelial stress signals shape innate and adaptive immunity. For this Special Issue, we invite original research and reviews that illuminate the molecular circuits linking keratinocytes, fibroblasts, and myeloid/lymphoid cells to clinical phenotypes and treatment response. We especially welcome studies dissecting photoimmunology and autoimmunity—such as type I interferon-driven pathways in cutaneous lupus erythematosus and dermatomyositis—as well as works on chronic wounds and neutrophilic dermatoses that reveal shared and divergent mechanisms of tissue injury and repair.
Cutting-edge methodologies are encouraged, including single-cell and spatial transcriptomics, proteomics, advanced imaging, and functional models (organoids, ex vivo human skin, and in vivo systems). Translational contributions that connect mechanism to biomarkers, patient-reported outcomes, and targeted therapies are of particular interest. We also welcome method papers and datasets that enable the reproducible analysis of complex human samples.
By bringing together mechanistic and clinically grounded studies, this Special Issue will identify actionable nodes in cytokine–chemokine networks, clarify stromal–immune crosstalk, and accelerate the development of diagnostics and therapeutics to measurably improve patients’ lives.
Dr. Nazgol-Sadat Haddadi
Guest Editor
Manuscript Submission Information
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Keywords
- photoimmunology
- keratinocyte stress
- type I interferon
- cutaneous lupus erythematosus
- der-matomyositis
- monocyte-derived dendritic cells
- fibroblast heterogeneity
- cytokine–chemokine networks
- single-cell and spatial omics
- targeted therapy
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