Amino Acid and Sugar Metabolism in Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 13
Special Issue Editor
2. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
Interests: metabolic diseases; metabolic disturbances; carbohydrate metabolism; aminoacid metabolism
Special Issue Information
Dear Colleagues,
The International Journal of Molecular Sciences is pleased to announce a Special Issue focusing on the metabolism of amino acids, sugars, and sweeteners in disease. This Special Issue will explore how alterations in these fundamental metabolic pathways may contribute to human pathology, ranging from inherited disorders to acquired metabolic dysfunctions.
Inborn errors of metabolism, caused by genetically encoded enzyme deficiencies, remain a critical research area due to the inconvenient metabolic paths and, in certain cases, the accumulation of toxic metabolites and their profound effects on neurological, cardiovascular, and hepatic systems. Likewise, disturbances in carbohydrate, amino acid and natural and synthetic sugar substitute metabolism underpin widespread health problems, including diabetes mellitus and metabolic syndrome. The increasing consumption of natural and artificial sweeteners introduces further complexity, as their biotransformation may modify metabolic routes, alter microbiota composition, and generate unexpected systemic effects. The situation becomes even more intricate when food additives are ingested in mixtures, potentially reshaping enzymatic activity, redox balance, and metabolic resilience.
We invite researchers to contribute original articles and reviews addressing the molecular and biochemical mechanisms linking amino acid, sugar, and sweetener metabolism to health and disease. Topics of interest include (but are not limited to):
- Novel genetically determined metabolic disorders and associated toxic metabolites;
- Mechanistic studies of altered pathways in amino acid and carbohydrate metabolism;
- The metabolic impact of natural and artificial sweeteners;
- Interactions between nutrients, additives, and the gut microbiome.
This Special Issue aims to provide a comprehensive platform for advancing knowledge and fostering innovative strategies in diagnosis, therapy, and nutrition.
Dr. V. Tkach
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic diseases
- metabolic disturbances
- carbohydrate metabolism
- aminoacid metabolism
- artificial sweeteners
- metabolic path alterations
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
