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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential

edited by Gabriela Cristina Brailoiu and Eugen Brailoiu

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction

(This special issue belongs to the Section Molecular Biology)

Neutrophil Extracellular Traps (NETs) in Human Disease: From Molecular Mechanisms to Therapeutic Translation

edited by

Michael Boettcher

and Julia Elrod

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: neutrophil extracellular traps (NETs); molecular mechanisms; human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Abiotic Stress Tolerance: 3rd Edition

edited by

Michael Moustakas

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: acclimation; drought; salinity; pesticides; high–low temperature; high–low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Immune Responses, Viral Infection and Neurodegenerative Diseases

edited by

Xin Dang

and Barbara Hanson

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Current Research on Neuroprotective Phytochemicals and Their Multi-Target Mechanisms

edited by

Gerardo Álvarez-Rivera

and

Alejandro Cifuentes

submission deadline 28 Feb 2026 | Viewed by 102 | Submission Open

Keywords: Alzheimer’ s disease; neuroprotective phytochemicals; green extraction; technologies; blood– brain barrier permeability; bioavailability; multi-target mechanisms; omics approaches; nanodelivery systems; brain health; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications

edited by

Marvin Xavierselvan

and

Steven Fiering

submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open

Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies

(This special issue belongs to the Section Molecular Nanoscience)

Liver Pathophysiology and Its Role in Systemic Diseases

edited by Vassilios Sevastianos

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: liver disease; endocrine functions; liver-targeted drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transcriptional Regulation in Plant Development: 3rd Edition

edited by

Konstantinos E. Vlachonasios

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant– environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Roles and Mechanisms of Non-Coding RNAs in Cancer

edited by Stefano Sechi and Daniela Scarabino

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: cancer; non-coding RNA (ncRNA); translational medicine; oncological therapy; biomarker; piRNA; lncRNA; circRNA

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges

edited by

Alessandra Micera

and

Filippo Biamonte

submission deadline 28 Feb 2026 | Viewed by 97 | Submission Open

Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence

(This special issue belongs to the Section Molecular Neurobiology)

Natural Products—the Underestimated Source of New Solutions for the Innovative Antimicrobial Therapies

edited by

Piotr Okińczyc

, Jarosław Widelski and

Jakub Szperlik

submission deadline 28 Feb 2026 | Viewed by 96 | Submission Open

Keywords: plant; medicines; natural product; antimicrobial activity; drug resistance; chemical analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application of Spectroscopic Methods in Molecular Biology Research

edited by

Łukasz Laskowski

submission deadline 28 Feb 2026 | Viewed by 95 | Submission Open

Keywords: spectroscopy; molecular characterization; biomaterials; computational chemistry; structure– property relationships; biomolecular interactions; biomedical applications

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: functional polymers; polymer synthesis; structure– property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition

edited by

Alfonso Baldi

submission deadline 28 Feb 2026 | Viewed by 93 | Submission Open

Keywords: endometriosis; reproductive system; endometrial cell; novel treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Phytochemicals in Plant Extracts: A Comprehensive Analysis of Their Diverse Chemical Structures and Therapeutic and Functional Effects

edited by

Truc Cong Ho

submission deadline 28 Feb 2026 | Viewed by 93 | Submission Open

Keywords: extraction; phytochemicals; bioactive compounds; second metabolites; nutraceuticals; polyphenols; flavonoids; biological effects; therapeutic effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Inorganic Chemistry: From Molecules to Materials

edited by

Zoi Lada

submission deadline 28 Feb 2026 | Viewed by 92 | Submission Open

Keywords: inorganic chemistry; molecular design and reactivity; metal– organic frameworks (MOFs); spin crossover compounds; functional materials; structure– property relationships

(This special issue belongs to the Section Materials Science)

Molecular Immunity to Parasitic Infections

edited by Jamie A. Whitelaw and Stuart Woods

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation

(This special issue belongs to the Section Molecular Immunology)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease: 2nd Edition

edited by

Marco Ragusa

and

Cristina Barbagallo

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Therapeutic Strategies for Surgical Tissue Damage, Repair and Regeneration

edited by Alex K. Wong

submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open

Keywords: surgical injury; tissue regeneration; vasculogenesis; wound healing in compromised settings; molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Angiogenesis: Mechanisms and Targets in a Wide Spectrum of Diseases

edited by Lei Phillip Wang

submission deadline 28 Feb 2026 | Viewed by 90 | Submission Open

Keywords: angiogenesis; immune– vascular interactions; cancer; autoimmune disease; neurodegenera-tion; blood– brain barrier; biomarkers; therapeutic targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electromagnetic Field Interactions with Biomolecules

edited by

Svetlana Jovanović

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: nonionizing electromagnetic fields; biomolecules; proteins; oxidative stress; Fe metabolism; amyloid-β peptide

(This special issue belongs to the Section Materials Science)

Mechanisms and Applications of Heterosis in Plants

edited by

Wenxin Liu

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: heterosis; mechanism; prediction; application; breeding; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Research into the Synthesis and Activities of Anticancer Compounds

edited by

Daniel Plano Amatriain

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: cancer; synthesis; cell biology; molecular biology; chemistry; preclinical development

(This special issue belongs to the Section Molecular Biology)

Antioxidant and Antidiabetic Potential of Natural Products in the Management of Diabetes and Its Complications

edited by

Ochuko Lucky Erukainure

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: diabetes; natural products; obesity; medicinal plants; oxidative stress; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metabolic Signaling and Inflammation in Cardiac Pathophysiology

edited by

Maria Luisa Barcena

submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open

Keywords: cardiac metabolism; inflammation; metabolic signaling; heart disease; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Perspective on Skeletal Muscle Regeneration

edited by Xuhui Liu

submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open

Keywords: skeletal muscle regeneration; satellite cells; stem cell niche; fibro/adipogenic progenitors; aging; muscle stem cells; cell– cell interactions; fibrosis and fatty infiltration; translational therapeutics

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Utilization of Environmental Microbial Resources

edited by

Hikmate Abriouel

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: environmental microbiology; molecular microbial resources; microbial metabolites; microbial diversity; microbial ecology; bioremediation; agricultural microbiology; omics technologies; biofilm formation; microbiome applications

(This special issue belongs to the Section Molecular Microbiology)

Molecular Perspectives on Female Infertility and Fertility

edited by

Seung-Yup Ku

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: female infertility; molecular mechanisms of reproduction; oocyte maturation and development; reproductive aging; polycystic ovary syndrome; endometriosis; epigenetic regulation in reproduction; oxidative stress and mitochondrial dysfunction; reproductive biomarkers; precision medicine and regenerative therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Sex Differences in Preclinical and Clinical Studies

edited by

Flavia Franconi

Valeria Raparelli

and

Ilaria Campesi

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: cellular and in vitro studies; genetic and epigenetic studies; intersectional studies; observational studies; pharmacological studies; pragmatic studies; randomized control trials; disease management

(This special issue belongs to the Section Molecular Biology)

Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights

edited by

Michele De Franco

submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open

Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology

edited by

Mariano Mastinu

submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open

Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia

(This special issue belongs to the Section Molecular Biology)

New Perspectives of Colloids for Biological Applications, 2nd Edition

edited by

Agnieszka Ewa Wia̧cek

submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open

Keywords: colloids; emulsions; dispersions; stability; size distribution; zeta potential; optical/rheological properties; medicine; pharmaceuticals; cosmetics

(This special issue belongs to the Section Materials Science)

RNA Biology and Regulation, 2nd Edition

edited by

Naoyuki Kataoka

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

Brain–Immune Crosstalk and Ischemic Injury

edited by

Yvonne Couch

submission deadline 28 Feb 2026 | 1 articles | Viewed by 82 | Submission Open

Keywords: stroke; ischemia; haemorrhage; inflammation; cytokines; macrophages; neutrophils; microglia; immunity

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Elicitation of Dormant Microorganisms for Anti-Cancer Therapy

edited by

Komal Anjum

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: dormant microbes; epigenetic; bioactive molecules; anti-cancer therapy; biosynthetic pathways; bioactive secondary metabolites

(This special issue belongs to the Section Molecular Genetics and Genomics)

Heterogeneous Catalysis Towards a Sustainable Future: Energy Conversion and Green Synthesis

edited by Chen Wu and

Shaodong Zhou

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: heterogeneous catalysis; CO2 hydrogenation; CO2 electroreduction; water splitting; Fischer-Tropsch synthesis; oxidative coupling of methane; methane dry reforming; green synthesis; fine chemicals; sustainable energy; catalyst design; active site engineering; single-atom catalysts; metal– organic frameworks; zeolites; nanostructured catalysts; in situ and operando characterizations; photocatalysis; electrocatalysis; biomass valorization; reaction engineering; renewable feedstocks

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research of Cognitive Impairment and Neuropsychiatric Symptoms in Late Life: From Pathogenesis to Treatment

edited by

Ioannis Liampas

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: dementia; Alzheimer’ s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’ s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Noble Metal Nanoparticles

edited by

Shinmori Hideyuki

submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open

Keywords: nanostructure; gold nanoparticles; silver nanoparticles; heterometallic nanoparticles; core– shell structure; surface chemistry; colloid chemistry; localized surface plasmon resonance

(This special issue belongs to the Section Molecular Nanoscience)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Metastasis and Therapy: Targeting the Tumor Microenvironment

edited by

Ravi Thakur

submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open

Keywords: cellular crosstalk; growth factors and cytokines; metastatic cascade; metabolic reprogramming; targeting tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Cellular Senescence at the Crossroads: From Cancer Protection to Chronic Disease

edited by

Alexander Lang

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: cellular senescence; SASP (Senescence-associated secretory phenotype); senolytics; therapeutic targeting; biomarkers of senescence

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Research on Taste Receptors

edited by

Ana R. Costa

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: taste receptors; taste signaling; gustatory system; molecular signaling; cellular mechanisms; health and disease; functional roles; neurobiology of taste; cancer biology and metastasis; translational research

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Proteinopathies in Neurodegenerative Diseases

edited by

Kyoung Joo Cho

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: protein misfolding; neurodegenerative diseases; protein aggregation; proteostasis; post-translational modifications; ubiquitin– proteasome system; autophagy; targeted protein degradation; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Tumor Organoids Uncovered: A Molecular Lens on Cancer Complexity

edited by Eleftherios Makris and

Konstantinos Ioannis Votanopoulos

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: tumor organoids; precision medicine; cancer modeling; drug screening; patient-derived models; molecular characterization; personalized therapy; translational research; biomarker discovery; clinical application

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Autoimmune and Inflammatory Rheumatic Diseases

edited by

Tanja Grubić-Kezele

submission deadline 28 Feb 2026 | Viewed by 74 | Submission Open

Keywords: autoimmune diseases; inflammatory diseases; rheumatic diseases; molecular mechanisms; pathogenesis; inflammation; central nervous system

(This special issue belongs to the Section Molecular Immunology)

Biological Polyphenols in Cognitive Impairment-Related Diseases: Effects, Dosage and Molecular Mechanisms

edited by

Chunmei Li

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: natural polyphenols; cognitive impairment-related diseases; Alzheimer's disease; Parkinson's disease; depression; anxiety; lowest effective dose; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies

edited by

Giuseppe Mannino

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO

(This special issue belongs to the Section Molecular Plant Sciences)

Training Immunity and Reprogramming Monocytes and Macrophages in Health and Disease

edited by Eugenio A. Carrera Silva

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: monocytes; macrophage plasticity; regulatory reprogramming; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Machine Learning in RNA and Chromatin Dynamics

edited by Haopeng Yu

submission deadline 28 Feb 2026 | Viewed by 73 | Submission Open

Keywords: machine learning; chromatin architecture; RNA dynamics; genomic foundation models; computational biology

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1751-1800 on page 36 of 67.

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