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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Plant Virus Infection, Resistance and Control
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1872 | Submission Open
Keywords: plant virus; host–pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1871 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Pregnancy-Related Complications
edited by Kallirhoe Kalinderi
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1845 | Submission Open
Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Functional Nanomaterials
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1774 | Submission Open
Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods
(This special issue belongs to the Section Molecular Nanoscience)
Mitochondrial Metabolism in Human Diseases
edited by Neelanjan Vishnu
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1771 | Submission Open
Keywords: mitochondrial function; pathophysiology; cellular processes; disease development
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Research Progress of Fluorescent Proteins in Molecular Biology
edited by Matteo Grenzi
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1766 | Submission Open
Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques
(This special issue belongs to the Section Molecular Biology)
Molecular Research of Host-Pathogen Interactions submission deadline 28 Feb 2027 | 2 articles | Viewed by 1713 | Submission Open
Keywords: host–pathogen interactions; host immunity during infection; new targets for resistant pathogens; molecular communication during infection; model systems in host–pathogen studies
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Natural Bioactive Compounds
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1687 | Submission Open
Keywords: natural products pharmacology; plant secondary metabolites; molecular mechanisms; phyto-chemicals; signal transduction pathways; structure–activity relationships; natural product
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Precision Medicine in Cancer: Biomarker and Bioinformatics Research
edited by and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1674 | Submission Open
Keywords: precision medicine; cancer biomarkers; bioinformatics; multi-omics; machine learning; tumor heterogeneity
(This special issue belongs to the Section Molecular Informatics)
Molecular Characterization and Utilization of Plant Genetic Resources
edited by
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1665 | Submission Open
Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Plant Breeding and Biotechnology: From Lab to Field
edited by
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1663 | Submission Open
Keywords: crop improvement; genetic transformation; omics approaches; plant metabolites; plant resistance; plant breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Animal Reproductive Biology and Genetic Breeding
edited by Chang Wu and Fangzhou Hu
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1645 | Submission Open
Keywords: genetic breeding; genetic variation; phenotype analysis; reproductive barrier; hybridization; multomics analysis
(This special issue belongs to the Section Molecular Biology)
Animal Models for Neurobiological Diseases submission deadline 28 Feb 2027 | 3 articles | Viewed by 1638 | Submission Open
Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions
(This special issue belongs to the Section Molecular Neurobiology)
Polymer Composites: Advances and Applications
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1630 | Submission Open
Keywords: polymer composites; polymer nanocomposites; biocompatible polymer composites; structure-property relationships; interfacial engineering; molecular design; computational modelling; mechanical performance; advanced applications
(This special issue belongs to the Section Materials Science)
Advanced Molecular Research on Kidney Diseases
edited by Joan Torras and Laura Martinez Valenzuela
submission deadline 28 Feb 2027 | 4 articles | Viewed by 1610 | Submission Open
Keywords: renal genomics; molecular; proteomics and metabolomics; cellular mechanisms and biomarkers; therapeutic innovations; translational and precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Decoding the Microbial Influence on Host Gene Expression submission deadline 28 Feb 2027 | 1 articles | Viewed by 1599 | Submission Open
Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo
(This special issue belongs to the Section Molecular Microbiology)
Interplay Between Cytoskeletal Dynamics and Cell Signaling in Cancer submission deadline 28 Feb 2027 | 2 articles | Viewed by 1509 | Submission Open
Keywords: cytoskeleton; cancer; organelle function; golgi apparatus; endoplasmic reticulum; mitochondria; post-translational modification; tumor invasion; metastasis; chemoresistance; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
The Characterization and Application of Enzymes in Bioprocesses, 2nd Edition submission deadline 28 Feb 2027 | 2 articles | Viewed by 1499 | Submission Open
Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing
(This special issue belongs to the Section Biochemistry)
Post-Transcriptional Gene Regulation of mRNA and Protein Expression
edited by Greco Hernández
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1465 | Submission Open
Keywords: translational control; protein synthesis; mRNA biochemistry; signal transduction; mTOR pathway; post-transcriptional regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic Determinants of Drug Response: From Molecular Mechanisms to Precision Therapy
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1464 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; drug response; drug metabolism; precision medicine; biomarkers; adverse drug reactions
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1437 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’s disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Early Diagnosis and Advanced Therapies of Genetic Disorders
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1433 | Submission Open
Keywords: genetic disorders; rare diseases; disease diagnostics; therapeutic targets; gene variants
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Bioenergetics and Signaling in Diseases submission deadline 28 Feb 2027 | 2 articles | Viewed by 1396 | Submission Open
Keywords: mitochondria; bioenergetics; oxidative phosphorylation; mitochondrial signaling; metabolism; reactive oxygen species (ROS); mitochondrial dynamics; mitophagy; calcium signaling; mitochondrial DNA; redox homeostasis; cell death; inflammation; neurodegeneration; cancer metabolism; cardiometabolic diseases; aging; therapeutic targeting
(This special issue belongs to the Section Biochemistry)
Brain–Organ Axis and Related Neurodegeneration submission deadline 28 Feb 2027 | 1 articles | Viewed by 1357 | Submission Open
Keywords: brain–organ axis; microbiota–gut–brain axis; neurodegenerative diseases; neuroinflammation; signaling pathways and alterations; innate immunity
(This special issue belongs to the Section Molecular Neurobiology)
Microfluidic Organ-on-a-Chip: Bridging Drug Discovery to Precision Medicine
edited by Yongjian Ai and Mengqi He
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1279 | Submission Open
Keywords: absorption; distribution; metabolism; excretion; toxicity; host–pathogen; host-immune; pharmacokinetic; pharmacodynamic; absorption; metabolism; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Cellular and Molecular Mechanisms of Neuroinflammation submission deadline 28 Feb 2027 | 2 articles | Viewed by 1261 | Submission Open
Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Adsorption Mechanisms: Theoretical and Experimental Studies submission deadline 28 Feb 2027 | 2 articles | Viewed by 1201 | Submission Open
Keywords: adsorption processes; adsorption mechanisms; adsorption equilibria; adsorption kinetics; porous materials; structure—property relationships; theoretical and experimental analysis; environmental, analytical, biomedical and technological applications
(This special issue belongs to the Section Molecular Biophysics)
Tumor Viruses: Infection, Carcinogenesis, and Treatment
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1190 | Submission Open
Keywords: tumor viruses; viral oncogenesis; EBV, HPV, KSHV, HBV, HCV, HTLV-1, and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Pathogen Interaction and Host Immunity
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1156 | Submission Open
Keywords: host–pathogen interactions; innate and adaptive immunity; pattern recognition receptors (PRRs); immune signaling pathways; cytokines and interferons; immune evasion mechanisms; molecular pathogenesis; infectious diseases
(This special issue belongs to the Section Molecular Immunology)
Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment
edited by Madan Mohan Kwatra
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1154 | Submission Open
Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Glyco-Based Anticancer Agents
edited by Pedro Colinas
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1148 | Submission Open
Keywords: carbohydrates; cancer; Warburg effect; glycolysis; enzyme inhibitors; transporters inhibitors; docking simulations; tumor microenvironment
(This special issue belongs to the Section Biochemistry)
Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants
edited by Chi-Rei Wu and Li-Wei Lin
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1142 | Submission Open
Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Molecular Insights into Myeloma
edited by Kotaro Shirakawa
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1138 | Submission Open
Keywords: multiple myeloma; clonal evolution and genetic heterogeneity; epigenomic dysregulation; transcriptional reprogramming; mitochondrial dysfunction; bone marrow microenvironment; tumor microenvironment; immunotherapy resistance; drug resistance; single-cell and spatial analysis
(This special issue belongs to the Section Molecular Oncology)
Molecular Pathogenesis, Immunobiology, and Treatment of Hematological Malignancies
edited by Tatsuro Jo
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1135 | Submission Open
Keywords: hematological malignancies; molecular pathogenesis; tumor microenvironment; immunogenomics; clonal evolution; biomarkers; immune monitoring; T-cell receptor repertoire; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Advances in Host-Pathogen Interactions in Plants: Molecular Mechanisms and Sustainable Strategies
edited by Muhammad Rahil Afzal and Misbah Naz
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1102 | Submission Open
Keywords: plant immunity; plant–pathogen interactions; molecular mechanisms; effector biology; hormonal crosstalk; non-coding RNAs and epigenetics
(This special issue belongs to the Section Molecular Plant Sciences)
Nanoparticle–Protein Interactions: Therapeutic Approaches and Supramolecular Chemistry
edited by Rodrigo da Silva Ferreira
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1085 | Submission Open
Keywords: nanoparticle–protein interactions; nanomedicine; supramolecular chemistry; surface functionalization; protein corona; nanocarriers; biointerfaces; molecular recognition; therapeutic nanomaterials; computational nano–bio modelling
(This special issue belongs to the Section Molecular Nanoscience)
Cardiovascular and Metabolic Sequelae of Peripheral Artery Disease: From Mechanisms to Therapeutic Targets
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1067 | Submission Open
Keywords: peripheral artery disease (PAD); cardiometabolic complications; molecular mechanisms; endothelial dysfunction; interorgan crosstalk
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications
edited by Marius Rǎdulescu
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1066 | Submission Open
Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure–property relationships; functionalized silica; sol–gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Polymeric Nanomaterials in Medicine
edited by Prabhanjan Giram
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1041 | Submission Open
Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies
(This special issue belongs to the Section Molecular Nanoscience)
Extracellular Vesicles: Biomarkers and Therapeutic Carriers in Human Health and Disease submission deadline 28 Feb 2027 | 1 articles | Viewed by 1019 | Submission Open
Keywords: extracellular vesicles; cellular senescence; autophagy; biomarkers; drug delivery; translational medicine; human disease; cell fate
(This special issue belongs to the Section Molecular Biology)
Chlorophylls and Carotenoids: Metabolism and Regulation in Plants
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1018 | Submission Open
Keywords: chlorophyll; carotenoid; metabolism; regulation; evolution; coordination
(This special issue belongs to the Section Molecular Plant Sciences)
New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 996 | Submission Open
Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling
(This special issue belongs to the Section Molecular Immunology)
Non-Coding RNAs and Post-Transcriptional Modifications in Cancer
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 994 | Submission Open
Keywords: solid tumors; hematological malignancies; long non-coding RNAs; circular RNAs; short non-coding RNAs
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insights into Gangliosides submission deadline 28 Feb 2027 | 1 articles | Viewed by 980 | Submission Open
Keywords: gangliosides; sphingolipids; plasma membrane; lysosomes; glycohydrolases; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Oral and Periodontal Health
edited by , Roxana Ioana Bordea and Grazia Marinelli
submission deadline 28 Feb 2027 | 1 articles | Viewed by 896 | Submission Open
Keywords: dental disease; dental materials; orthodontic diseases; growth factor; regenerative tissue; peritonitis; regulatory T cells; systemic disease; systemic inflammation; scaling and root planning
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Plant–Microbial Interaction
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 869 | Submission Open
Keywords: plant microbe intractions; molecular mechanisms; microbiome dynamics; multi-omics approach; stress responses; metagenomics; rhizosphere signalling
(This special issue belongs to the Section Molecular Microbiology)
Molecular Atlas of Cardiac Development and Diseases submission deadline 28 Feb 2027 | Viewed by 861 | Submission Open
Keywords: cardiac development; molecular atlas; cardiovascular disease; single cell and spatial omics; multi omics integration; gene regulatory networks; cardiac remodeling; heart failure; systems biology; artificial intelligence in cardiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Algal Stress Physiology
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 819 | Submission Open
Keywords: algae; microalgae; cyanobacteria; stress physiology; molecular mechanisms; signal transduction; gene regulation; redox homeostasis; omics technologies; environmental stress; metabolic adaptation; biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Hormone/Receptor System in Human Diseases
edited by Elena Zocchi, and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 808 | Submission Open
Keywords: hormone; receptor; energy metabolism; mitochondria
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Plant Metabolism and Genetics
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 795 | Submission Open
Keywords: plant metabolism; genetics; genomics; multi-omics integration; secondary/specialized metabolites; biosynthetic pathways; metabolic engineering crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
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