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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Intracellular Signal Transduction Systems
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2789
Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease
(This special issue belongs to the Section Molecular Biology)
Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2755
Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds
(This special issue belongs to the Section Molecular Pharmacology)
The Role of microRNA in Human Diseases: 3rd Edition submission deadline 20 Nov 2025 | 1 articles | Viewed by 2726
Keywords: microRNA (miRNA); non-coding RNAs; human diseases; cancer; fatty liver; cardiovascular diseases; neurological diseases; viral infection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathology and Treatment of Heart Failure
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2707
Keywords: heart failure; oxidative stress; platelet activation; inflammation; biomarkers; pathophysiology; comorbidities
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Breakthroughs in Cardiac Tissue Remodeling: From Mechanisms to Therapeutics
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2697
Keywords: myocardial infarction; heart failure; adverse remodeling; cardiac fibrosis; cardiomyopathy; cardiotoxicity; ventricular remodeling; cardiac dysfunction; biomarkers; cardiac regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Cellular and Molecular Insights into Glaucoma submission deadline 20 Nov 2025 | 1 articles | Viewed by 2670
Keywords: neuroinflammation; microglia; macroglia; retinal ganglion cells; therapeutical approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Developments in Molecular Genetic Breeding of Forest Trees
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2649
Keywords: tree genetics; tree breeding; molecular breeding; genetic improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Interactions between Plants and Nematodes
edited by Qian Liu
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2628
Keywords: plant nematodes; hosts; interaction; effectors; giant cells; syncytia
(This special issue belongs to the Section Molecular Plant Sciences)
Role of Extracellular Vesicles in Diseases submission deadline 20 Nov 2025 | 1 articles | Viewed by 2625
Keywords: extracellular vesicles (EVs); biomarkers; disease pathophysiology; miRNAs; intercellular communication; therapeutic targets; mitochondrial transfer; cancer; neurodegenerative disorders; precision medicine
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Signaling Pathways in Neuroinflammatory Disorders submission deadline 20 Nov 2025 | 1 articles | Viewed by 2593
Keywords: blood– brain barrier; inducible pluripotent stem cells; organoids; scaffolds; neuroinflammation; microglia; mitochondria; endothelial cells; drug screening; virus infections; cryo-EM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Omics in Cancer Diagnosis and Treatment
edited by Xiaohu Tang
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2577
Keywords: cancer; heterogeneity; omics; biomarker; therapeutic targets; drug resistance; molecular profile; algorithm
(This special issue belongs to the Section Molecular Oncology)
Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections submission deadline 20 Nov 2025 | 1 articles | Viewed by 2548
Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Precision Medicine in Cancers submission deadline 20 Nov 2025 | 1 articles | Viewed by 2500
Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research
(This special issue belongs to the Section Molecular Oncology)
Glial Cells in Neurodegenerative Disorders
edited by Daniel Souza Monteiro de Araujo
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2482
Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders
(This special issue belongs to the Section Molecular Neurobiology)
Basic, Translational and Clinical Research on Dementia—Second Edition
edited by , and Daniele Bano
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2467
Keywords: dementia; Alzheimer’ s disease; amyloid-beta; tau protein
(This special issue belongs to the Section Molecular Neurobiology)
Lipopolysaccharide in the Health and Disease
edited by and Hiroyuki Inagawa
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2420
Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer
(This special issue belongs to the Section Biochemistry)
Advances in Molecular Biology on Mycobacteria: 2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2274
Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction
(This special issue belongs to the Section Molecular Microbiology)
Computational Modelling at the Blood–Brain Barrier
edited by Christian Jorgensen
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2249
Keywords: blood– brain barrier models; molecular dynamics simulations; artificial intelligence; CNS penetration predictive models; asymmetric membranes; efflux pumps
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights and Innovations in Brain Cancer Research
edited by Vinay K. Sharma
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2245
Keywords: glioblastomas; astrocytomas; brain tumors; targeted therapies; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2216
Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry
(This special issue belongs to the Section Materials Science)
Molecular and Cellular Mechanisms of Comorbidities in Rheumatic Diseases
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2198
Keywords: inflammatory and autoimmune rheumatic diseases; comorbidities; autoimmunity; T-cell response
(This special issue belongs to the Section Molecular Immunology)
Sulfur-Containing Compounds: Synthesis, Characterization and Antimicrobial or Anticancer Activity submission deadline 20 Nov 2025 | 1 articles | Viewed by 2187
Keywords: sulfurated compounds; sulfoxides; disulfides; sulfides; thiosulfinates; xanthates; antibacterial; antivirus; anticancer; antimicrobial
(This special issue belongs to the Section Biochemistry)
Cancer Biology: From Genetic Aspects to Treatment, 2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2171
Keywords: cancer biology; cancer biomarker; cancer progression; cancer metastasis; genetic of cancer
(This special issue belongs to the Section Molecular Oncology)
ROS Signalling and Cell Turnover submission deadline 20 Nov 2025 | 2 articles | Viewed by 2061
Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death
(This special issue belongs to the Section Biochemistry)
Molecular Crosstalk Between Bone and Inflammation
edited by Jessica Cottrell
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1843
Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease
(This special issue belongs to the Section Molecular Immunology)
Molecular Pathophysiology and Treatment of Coronary Artery Disease
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1648
Keywords: coronary artery disease; ischemic cardiomyopathy; immune-related adverse events; CAD associated with autoimmune diseases; coronary artery disease-related cardiomyopathy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds in Neurodegenerative Diseases
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1625
Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Physiological Analysis of Stress in Plants
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1617
Keywords: plant stress; biotic stress; abiotic stress; stress response; gene expression; epigenetic stress memory; ABA; SA
(This special issue belongs to the Section Molecular Plant Sciences)
Reproductive Physiology and miRNA-Mediated Gene Regulation in Domestic Animals submission deadline 20 Nov 2025 | 1 articles | Viewed by 1613
Keywords: reproductive physiology; microRNAs; miRNAs; gene regulation; domestic animals
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Antifungal Resistance and Virulence submission deadline 20 Nov 2025 | 1 articles | Viewed by 1604
Keywords: fungal infections; antifungal therapies; antifungal resistance; fungal virulence
(This special issue belongs to the Section Molecular Microbiology)
Toxicants and Their Effects on Innate Immune Function and Inflammatory Response
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1565
Keywords: ecotoxicology; innate immunity; inflammation; pesticides; plasticizers; pattern-recognition receptors
(This special issue belongs to the Section Molecular Toxicology)
Nanodiagnosis and Treatment System for Human Health
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1564
Keywords: nanodiagnosis; nanodrugs; nano-antibody; nanosensor; nanoprobe technology
(This special issue belongs to the Section Molecular Nanoscience)
New Advances of Free-Radical Reactions in Organic Chemistry
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1557
Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Composites of Carbon Nanomaterials and Transition Metals: Preparation, Properties, Bioapplications
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1492
Keywords: composite materials; carbon nanomaterials; nanoparticles of transition metals and their compounds; preparation and functionalization of composite materials; biosensors; bioapplications
(This special issue belongs to the Section Molecular Nanoscience)
Applications of Phytochemicals in Drug Synthesis
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1487
Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts
(This special issue belongs to the Section Bioactives and Nutraceuticals)
DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1433
Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders
(This special issue belongs to the Section Molecular Genetics and Genomics)
Drug Repositioning: Current Challenges and Future Perspectives of a Sustainable Experimental and In Silico Approach submission deadline 20 Nov 2025 | 2 articles | Viewed by 1388
Keywords: drug discovery; drug repositioning; biologics; small molecules; artificial intelligence (AI); cancer; neurodegenerative diseases; therapeutic strategies
(This special issue belongs to the Section Molecular Pharmacology)
Toxicology and Pharmacology of Natural Products
edited by , Cheng Zhang and Sha Li
submission deadline 20 Nov 2025 | Viewed by 1362
Keywords: pharmacology; toxicology; natural products; Chinese medicine; drug discovery; safety assessment; ethnopharmacology; analytical techniques; regulatory frameworks
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Genomic Research in Carcinogenesis, Cancer Progression and Recurrence submission deadline 20 Nov 2025 | 1 articles | Viewed by 1328
Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers
(This special issue belongs to the Section Molecular Oncology)
Cutting-Edge Advances in New Anticancer Agents: Design, Synthesis and Application
edited by Mahendiran Dharmasivam
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1266
Keywords: combination therapies in oncology; small-molecule inhibitors in cancer treatment; natural-product-based cancer therapeutics; immunotherapy advancements in oncology; targeting metastatic dormancy in cancer; modulating the tumour microenvironment for therapeutic benefit; three-dimensional cancer models in drug discovery; predictive biomarkers for chemoresistance; medicinal chemistry approaches in anticancer agent design; drug development strategies for resistant cancers
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Orchid Plants: 2nd Edition
edited by Wen‑Chieh Tsai
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1252
Keywords: orchid; genomics; genome; genes; tumor; inflammation; drug; transcriptomics
(This special issue belongs to the Section Molecular Plant Sciences)
Conversion and Valorization of Lignocellulosic Biomass submission deadline 20 Nov 2025 | 1 articles | Viewed by 1237
Keywords: lignocellulosic biomass; vegetal and agro processing wast; catalytic and biocatalytic conversion; value added products; lignocellulosic platform; bioprocessing; biorefinery; green chemistry; circular economy; bioeconomy
(This special issue belongs to the Section Biochemistry)
Melanoma: From Molecular Mechanisms to Therapeutics
edited by Dorota Ciołczyk-Wierzbicka
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1118
Keywords: melanoma; molecular mechanism; signaling pathways; genetic mutations; cancer therapy/treatment; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Role of Protein Post-Translational Modifications in Cancer: Mechanisms and Therapeutic Opportunities submission deadline 20 Nov 2025 | 1 articles | Viewed by 1084
Keywords: phosphorylation; acetylation; methylation; sumoylation; ubiquitination; glycosylation; acylation; signal transduction; inhibitors
(This special issue belongs to the Section Biochemistry)
Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials submission deadline 20 Nov 2025 | 1 articles | Viewed by 1069
Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials
(This special issue belongs to the Section Materials Science)
Molecular Genetics and Breeding Mechanisms in Crops: 3rd Edition
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1058
Keywords: crops; molecular genetics; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Sprouty Proteins in Cancer
edited by Barbara Hausott and
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1028
Keywords: sprouty; tumor growth; apoptosis; migration; signaling
(This special issue belongs to the Section Molecular Biology)
Nucleolus, Nucleolar Stress, and Ribosome Biogenesis in the Nervous System submission deadline 20 Nov 2025 | Viewed by 968
Keywords: nucleolus; nucleolar stress; nucleolar homeostasis; polymerase I; rDNA transcription; ribosome biogenesis; translation; ribosomopathies; apoptosis; autophagy; senescence; neurodegeneration; tumorigenesis
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Models: Development and Applications
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 950
Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Aquatic Organisms Models Dedicated to Disease submission deadline 20 Nov 2025 | Viewed by 891
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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