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The Role of microRNA in Human Diseases 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 1662

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issues, “The Role of microRNA in Human Diseases” and “The Role of microRNA in Human Diseases 2.0”.

MicroRNA (miRNA) is a class of small (about 22 nt long) noncoding RNAs whose main function is in the negative post-transcriptional and translational regulation of gene expression. In most cases, this regulation is mediated by the complementary binding of miRNA to the 3′ UTR of the target mRNA to promote its degradation and/or translational repression. Furthermore, multiple reports have consistently shown that aberrant miRNA expression is associated with various human diseases, including cancer and neurological and cardiovascular diseases. Finally, some host- and virus-encoded miRNAs can contribute to the process of infection by targeting certain mRNAs (both host and viral).

This Special Issue focuses on the roles of aberrant miRNA expression in different human diseases, as well as the characterization of putative miRNA targets for therapeutic intervention. In particular, studies involving advanced deep sequencing methods and novel bioinformatics algorithms for miRNA research (focus on a molecular level) are highly welcomed. The formats for submission include original research reports, reviews, and communications.

Dr. Andrey Turchinovich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • microRNA (miRNA)
  • non-coding RNAs
  • human diseases
  • cancer
  • fatty liver
  • cardiovascular diseases
  • neurological diseases
  • viral infection

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Published Papers (1 paper)

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Research

20 pages, 2300 KiB  
Article
Human miR-1 Stimulates Metabolic and Thermogenic-Related Genes in Adipocytes
by Ester Díez-Sainz, Fermín I. Milagro, Paula Aranaz, José I. Riezu-Boj, Pierre-Louis Batrow, Laura Contu, Nadine Gautier, Ez-Zoubir Amri, Isabelle Mothe-Satney and Silvia Lorente-Cebrián
Int. J. Mol. Sci. 2025, 26(1), 276; https://doi.org/10.3390/ijms26010276 - 31 Dec 2024
Viewed by 971
Abstract
MicroRNAs play a pivotal role in the regulation of adipose tissue function and have emerged as promising therapeutic candidates for the management of obesity and associated comorbidities. Among them, miR-1 could be a potential biomarker for metabolic diseases and contribute to metabolic homeostasis. [...] Read more.
MicroRNAs play a pivotal role in the regulation of adipose tissue function and have emerged as promising therapeutic candidates for the management of obesity and associated comorbidities. Among them, miR-1 could be a potential biomarker for metabolic diseases and contribute to metabolic homeostasis. However, thorough research is required to fully elucidate the impact of miR-1 on human adipocyte thermogenesis and metabolism. This study aimed to explore the effect of miR-1 on human adipocyte browning, a process whose activation has been linked to obesity protection and counteraction. Human multipotent adipose-derived stem cells, hMADS cells, were differentiated into white and brown-like adipocytes and transfected with miR-1 mimics for gene expression and western blotting analyses. miR-1 inhibited the expression of its previously validated target PTK9/TWF1 and modulated the expression profile of key genes involved in thermogenesis and adipocyte browning (increased UCP1 at mRNA and protein level, increased CPT1M, decreased HIF3A), adipocyte differentiation and metabolism (decreased PLIN1, FASN, RXRA, PPARG, FABP4, MAPKAPK2), as well as genes related to the cytoskeleton (decreased ACTB) and extracellular matrix (decreased COL1A1). These findings suggest that miR-1 can modulate the expression of adipocyte human genes associated with thermogenesis and metabolism, which could hold value for eventual therapeutic potential in obesity. Full article
(This article belongs to the Special Issue The Role of microRNA in Human Diseases 3.0)
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