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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment submission deadline 20 Feb 2026 | Viewed by 206 | Submission Open
Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment
(This special issue belongs to the Section Molecular Oncology)
Nanotechnology for Food Science—Innovations and Sustainable Solutions
edited by
submission deadline 20 Feb 2026 | Viewed by 205 | Submission Open
Keywords: nanotechnology; nanomaterial synthesis; food safety; food science; nano-engineered food additives; nano-sensors
(This special issue belongs to the Section Molecular Nanoscience)
Roles of Exosomes in Health and Disease
edited by
submission deadline 20 Feb 2026 | Viewed by 203 | Submission Open
Keywords: exosomes; extracellular vesicles; intercellular communication; diagnostics; therapeutics; disease; biomarkers; cellular biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Development Biology of Immune Cells
edited by Jacek Z. Kubiak
submission deadline 20 Feb 2026 | Viewed by 203 | Submission Open
Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells
(This special issue belongs to the Section Molecular Immunology)
Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms
edited by and
submission deadline 20 Feb 2026 | Viewed by 199 | Submission Open
Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights
edited by Ioannis Alexandros Charitos
submission deadline 20 Feb 2026 | Viewed by 198 | Submission Open
Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut– oral-microbiota– brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics
(This special issue belongs to the Section Molecular Microbiology)
Development and Applications of Biodegradable and Bioactive Materials submission deadline 20 Feb 2026 | Viewed by 194 | Submission Open
Keywords: biopolymers; bioplastics; sustainability; food packaging; medicine and cosmetic; bioactive compounds; wound healing; active and intelligent packaging
(This special issue belongs to the Section Materials Science)
Electron or Ion Transport in Electrochemistry
edited by Simone Sanna
submission deadline 20 Feb 2026 | Viewed by 194 | Submission Open
Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Theranostic Application of Reactive Oxygen Species-Sensitive Nanocarriers
edited by
submission deadline 20 Feb 2026 | Viewed by 192 | Submission Open
Keywords: ROS generation; ROS detection; ROS-sensitive nanoparticles; Photodynamic therapy (PDT)
(This special issue belongs to the Section Molecular Nanoscience)
Contribution of Astrocytes and Microglia for the Development of Neurological Disorders submission deadline 20 Feb 2026 | Viewed by 190 | Submission Open
Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research in Immune Cell Therapy
edited by
submission deadline 20 Feb 2026 | Viewed by 189 | Submission Open
Keywords: molecular biology; bioinformatics; proteomics; molecular mechanisms; genomics
(This special issue belongs to the Section Molecular Immunology)
Molecular Advances of Layered Double Hydroxides (LDH) for Corrosion Protection
edited by
submission deadline 20 Feb 2026 | Viewed by 188 | Submission Open
Keywords: layered double hydroxide (LDHs); corrosion resistance; coatings; corrosion products
(This special issue belongs to the Section Materials Science)
New Advances in Plant Genetic Research
edited by
submission deadline 20 Feb 2026 | Viewed by 187 | Submission Open
Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science
(This special issue belongs to the Section Molecular Plant Sciences)
NURR1 Biology in Neurological Disorders and Other Diseases submission deadline 20 Feb 2026 | Viewed by 186 | Submission Open
Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases
(This special issue belongs to the Section Molecular Biology)
From Pathogenic Mechanisms to Therapy in Retinal Diseases submission deadline 20 Feb 2026 | Viewed by 181 | Submission Open
Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Antiviral Agents and Antiviral Therapy submission deadline 20 Feb 2026 | Viewed by 176 | Submission Open
Keywords: therapeutics; high-throughput screening; viral reverse genetics; luciferase; fluorescent; compound; repurpose; antiviral; diagnostics
(This special issue belongs to the Section Molecular Immunology)
Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation
edited by Genyi Zhang
submission deadline 20 Feb 2026 | Viewed by 176 | Submission Open
Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets
edited by Uchenna John Unachukwu
submission deadline 20 Feb 2026 | Viewed by 175 | Submission Open
Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics
(This special issue belongs to the Section Molecular Biology)
Age-Dependence of Neuroimmune Reactions
edited by
submission deadline 20 Feb 2026 | Viewed by 172 | Submission Open
Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases
(This special issue belongs to the Section Molecular Immunology)
Natural Compounds in Cancer: Targeting Immune Cells and Signalling Pathways submission deadline 20 Feb 2026 | Viewed by 169 | Submission Open
Keywords: natural compounds; cancer; inflammation; signalling pathways; antineoplastic agents; macrophage; T cells; molecular mechanism of pharmacological action; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Electrochemistry and Emerging Contaminants: Molecular Insights for Innovative Solutions
edited by
submission deadline 20 Feb 2026 | Viewed by 164 | Submission Open
Keywords: electrochemistry; chemical reactions; removal; environmental pollution
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Plasticity in Multiple Sclerosis: From Molecular to System Level, from Adaptation to Maladaptation
edited by Gloria Dalla Costa and Laura Cacciaguerra
submission deadline 20 Feb 2026 | Viewed by 160 | Submission Open
Keywords: multiple sclerosis; neuroplasticity; remyelination; synaptic adaptations
(This special issue belongs to the Section Molecular Neurobiology)
Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics
edited by
submission deadline 20 Feb 2026 | Viewed by 150 | Submission Open
Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis
(This special issue belongs to the Section Biochemistry)
Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Insights submission deadline 20 Feb 2026 | Viewed by 147 | Submission Open
Keywords: transcription machinery; transcription (co)factors; chromatin regulators; splicing regulators; noncoding RNAs; transcription misregulation; genetic alterations; human diseases; transcriptome profiling; bioinformatics analysis
(This special issue belongs to the Section Molecular Biology)
The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
edited by Gabriela Verónica Salamone
submission deadline 20 Feb 2026 | Viewed by 139 | Submission Open
Keywords: gliomas tumor microenvironment immune
(This special issue belongs to the Section Molecular Oncology)
Recent Research in Nanoelectrochemistry
edited by
submission deadline 20 Feb 2026 | Viewed by 138 | Submission Open
Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications
(This special issue belongs to the Section Materials Science)
Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications
edited by
submission deadline 20 Feb 2026 | Viewed by 135 | Submission Open
Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical
(This special issue belongs to the Section Molecular Biophysics)
Molecular Progress in Male Reproduction
edited by
submission deadline 20 Feb 2026 | Viewed by 131 | Submission Open
Keywords: male infertility; spermatogenesis; epigenetics; sperm function; testicular molecular biology; bioinformatics; reproductive genomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Fungal Genetics and Functional Genomics Research
edited by and
submission deadline 20 Feb 2026 | Viewed by 113 | Submission Open
Keywords: enzymes; fungal genetics; fungi; gene editing; regulation; secondary metabolites; synthetic biology; transcription
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances in Gestational Diabetes Mellitus: 2nd Edition
edited by Natasha Singh
submission deadline 20 Feb 2026 | Viewed by 107 | Submission Open
Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Abiotic Stress in Plants, 2nd Edition
edited by
submission deadline 20 Feb 2026 | Viewed by 105 | Submission Open
Keywords: abiotic stress; ROS; redox; antioxidants; phytohormones; ethylene; plant stress eco-physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition
edited by Vija Lavinia
submission deadline 20 Feb 2026 | Viewed by 102 | Submission Open
Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biophysical Studies of Protein Structure-Function Relationships
edited by , and Velia Minicozzi
submission deadline 20 Feb 2026 | Viewed by 86 | Submission Open
Keywords: protein structure; molecular dynamics; computational modeling; drug discovery
(This special issue belongs to the Section Molecular Biophysics)
Decoding Protein Structure and Protein Dynamics in Cancer submission deadline 20 Feb 2026 | Viewed by 83 | Submission Open
Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Molecular Progress of Cardiovascular and Metabolic Disease
edited by
submission deadline 20 Feb 2026 | Viewed by 82 | Submission Open
Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies
edited by
submission deadline 20 Feb 2026 | Viewed by 78 | Submission Open
Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Genetic and Epigenetic Research in Skin Diseases
edited by
submission deadline 20 Feb 2026 | Viewed by 56 | Submission Open
Keywords: skin diseases; genodermatoses; psoriasis; atopic dermatitis; hidradenitis; suppurativa; epigenetic regulation; genome-wide association studies (GWAS); next-generation sequencing; translational dermatogenomics; Mendelian randomization; rare disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of the Mitochondria in Human Health and Diseases submission deadline 25 Feb 2026 | 2 articles | Viewed by 13214 | Submission Open
Keywords: mitochondria; mitochondria contact sites; metabolism; lipids; metabolites
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Cell Proliferation, Senescence and Apoptosis
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 7490 | Submission Open
Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Human Retrovirus Infection: 2nd Edition
edited by , and Kotaro Shirakawa
submission deadline 25 Feb 2026 | 3 articles | Viewed by 7479 | Submission Open
Keywords: retrovirus; ATL; HIV-1; AIDS
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research on Skin Inflammation
edited by
submission deadline 25 Feb 2026 | 4 articles | Viewed by 7372 | Submission Open
Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multifunctional Nanocomposites for Bioapplications submission deadline 25 Feb 2026 | 5 articles | Viewed by 7200 | Submission Open
Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli
(This special issue belongs to the Section Molecular Nanoscience)
Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases
edited by Capercomorin S. Pitchumoni and
submission deadline 25 Feb 2026 | 2 articles | Viewed by 6660 | Submission Open
Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Host-Directed Antiviral Therapies submission deadline 25 Feb 2026 | 1 articles | Viewed by 6635 | Submission Open
Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Understanding Aging in Health and Disease
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 5984 | Submission Open
Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Forensic Toxicology: Innovative Approaches in Detection of New Psychoactive Substances
edited by Roberta Tittarelli and Giulio Mannocchi
submission deadline 25 Feb 2026 | 2 articles | Viewed by 5634 | Submission Open
Keywords: addiction; new psychoactive substances; mass spectrometry; biological matrices; diversion; forensic toxicology; drug testing
(This special issue belongs to the Section Molecular Toxicology)
Reproductive Genetics and Epigenetics: Insights into Infertility Failures and Treatment Pathways
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 5472 | Submission Open
Keywords: infertility; epigenetics; polymorphism; gametogenesis; fertilization; embryo development; reproductive organs; congenital malformations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advancements in Understanding Protein Misfolding Disorders and Cancer
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 4714 | Submission Open
Keywords: protein misfolding; cancer; amyloidosis
(This special issue belongs to the Section Molecular Oncology)
Peptide Self-Assembly
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 4453 | Submission Open
Keywords: peptide assembly; aromatic short peptides; bioinspired supramolecular architectures; functional materials; peptide microfabrication; anticancer therapy; supercapacitor; biosensing
(This special issue belongs to the Section Macromolecules)
Molecular Advances in Electrochemical Materials
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 4316 | Submission Open
Keywords: electrochemical materials; molecular design; energy storage; electrocatalysis; sensing applications; nanomaterials; sustainable materials; hybrid systems; interface engineering; green chemistry
(This special issue belongs to the Section Materials Science)
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