Theranostic Application of Reactive Oxygen Species-Sensitive Nanocarriers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 71
Special Issue Editor
Interests: cancer; reactive oxygen species; nanomedicine; anticancer agents; drug-delivery system; ROS-sensitive nanomaterials; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular oxidative stress leads to DNA damage and abnormal gene expression. This physiological change can lead to the proliferation of abnormal cells and, as a result, carcinogenesis. Oxidative stress in tumor tissues is due to elevated ROS levels compared to normal cells or tissues. Elevated ROS levels are known to have a critical role in cancer initiation and progression. Especially, the role of ROS frequently depends on the concentration; i.e., an appropriate ROS level leads to the proliferation, migration, and invasion of tumor cells, while the overproduction of ROS leads to the apoptotic death of cancer cells.
Nanocarriers have been spotlighted in the field of tumor targeting. Since nanocarriers can be designed to respond to ROS, they can be used for tumor targeting with anticancer drugs and bioactive molecules. ROS-sensitive nanocarriers can be used for both diagnostic and therapeutic purposes in tumors. ROS-sensitive nanocarriers can be used for diagnostic purposes in tumors because their physicochemical properties can be sensitively changed under ROS concentration, and then they can liberate diagnostic molecules in the target cells/tissues. Furthermore, ROS-sensitive nanocarriers can be used to kill tumors through the overproduction or suppression of ROS levels in tumors. Various bioactive ROS-producing agents have been developed to kill cancer cells. Therefore, ROS-sensitive nanocarriers are promising candidates for theranostic applications in tumor targeting.
Some of the topics related to the theranostic application of ROS-sensitive nanocarriers to be tackled in this Special Issue include but are not limited to:
- Molecular mechanism of ROS generation and its detection in cells;
- ROS-producing molecules for diagnosis/therapeutic application;
- ROS-sensitive nanoparticles and their application in tumor targeting;
- Photodynamic therapy.
Dr. Young-Il Jeong
Guest Editor
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Keywords
- ROS generation
- ROS detection
- ROS-sensitive nanoparticles
- Photodynamic therapy (PDT)
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