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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research on the Drug Toxicity submission deadline 20 Nov 2025 | 2 articles | Viewed by 5127 | Submission Open
Keywords: drug toxicity; new psychoactive substances; toxicology; drug metabolism; drug intoxication
(This special issue belongs to the Section Molecular Toxicology)
Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development
edited by Karl Kerns
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4888 | Submission Open
Keywords: sperm development  ; germ cell proliferation  ; sperm cell metabolism  ; seminal fluid biochemical composition  ; spermatogenesis  ; epididymal maturation  ; sperm capacitation  ; oocyte activation  
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass submission deadline 20 Nov 2025 | 2 articles | Viewed by 4773 | Submission Open
Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization
(This special issue belongs to the Section Biochemistry)
Basic Mechanisms of Physiological and Pathological Autoimmunity and Their Role in the Development of Autoimmune Diseases
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4637 | Submission Open
Keywords: physiologic autoimmunity; autoimmune diseases; natural immune system; pathologic autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Advanced Catalytic Materials (Second Edition)
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4610 | Submission Open
Keywords: synthetic routes; nanomaterials; catalysis; sustainability; biomass; biofuel; photocatalysis; fine chemistry
(This special issue belongs to the Section Materials Science)
Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements
edited by
submission deadline 20 Nov 2025 | 7 articles | Viewed by 4572 | Submission Open
Keywords: Sjö gren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oral Cancer: Update on Molecular Pathology, Mechanisms and Treatments
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4510 | Submission Open
Keywords: oral cancer; mechanisms of incidence and development of oral cancer; metastasis; diagnosis; biomarkers; treatments (active ingredients; medicines; biomedicines; and gene therapy)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drosophila: A Versatile Model in Biology and Medicine—2nd Edition submission deadline 20 Nov 2025 | 6 articles | Viewed by 4472 | Submission Open
Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics
(This special issue belongs to the Section Molecular Biology)
Advances in Micro- and Nanomaterials for Biomedical Applications
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4429 | Submission Open
Keywords: biomaterials; medical applications; natural and synthetic polymers; tissue engineering; hydrogels; bone cement; drug delivery systems; dendrimers; micro- and nanocomposites; nanotechnology; bioceramics; biopharmaceutics; biosensing
(This special issue belongs to the Section Molecular Nanoscience)
Natural Products and Synthetic Derivatives in Cancer and Inflammatory Diseases
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4428 | Submission Open
Keywords: angiogenesis inhibition; caspase activation; cytokine modulation; drug discovery; ethnopharmacology; plant metabolites; marine natural products; molecular docking; oxidative stress; tumor microenvironment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Microbiota and Cancer: 4th Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 4423 | Submission Open
Keywords: gut microbiota; cancer; hematopoietic stem cell transplantation; human microbiome; immune system; colon cancer; carcinogenesis; nutrition; short-chain fatty acids; metagenomic; dysbiosis
(This special issue belongs to the Section Molecular Oncology)
Molecular Aspects of Hematological Malignancies and Benign Hematological Disorders—3rd Edition submission deadline 20 Nov 2025 | 3 articles | Viewed by 4420 | Submission Open
Keywords: myeloproliferative neoplasms; leukemia; lymphoma; multiple myeloma; oxidative stress; inflammation; microbiome; genetics; molecular biology
(This special issue belongs to the Section Molecular Biology)
Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4380 | Submission Open
Keywords: molecular detection; analytical techniques; nanosensors; food science; DNA analysis
(This special issue belongs to the Section Biochemistry)
Metabolomics in the Field of Autoimmune Diseases submission deadline 20 Nov 2025 | 2 articles | Viewed by 4364 | Submission Open
Keywords: metabolomics; proteomics; genomics; transcriptomics; biomarkers; autoimmune diseases; inflammatory diseases; nuclear magnetic resonance spectroscopy; mass spectrometry; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Synthesis of Advanced Polymer Materials, 3rd Edition
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 4340 | Submission Open
Keywords: polymer synthesis; polymer chemistry; coordination polymerization; organometallic catalysts; polyolefin; degradable polymer materials; green and sustainable polymeric materials; homogeneous polymerization; heterogeneous polymerization
(This special issue belongs to the Section Macromolecules)
Antioxidant and Antibacterial Properties of Phytochemicals
edited by and Vytaute Starkute
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4305 | Submission Open
Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed
(This special issue belongs to the Section Bioactives and Nutraceuticals)
FTIR Miscrospectroscopy: Opportunities and Challenges
edited by Simona Sabbatini
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4301 | Submission Open
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation
edited by Rossana Scuri
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4298 | Submission Open
Keywords: arteriolar networks organization; blood flow supply; cardiovascular disease; endothelial dysfunction; eNOS regulatory activity; oxidative stress; polyphenols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Molecular Basis of Plant–Microbe Interactions submission deadline 20 Nov 2025 | 3 articles | Viewed by 4232 | Submission Open
Keywords: plant immune and defense responses; microbe and microbiome function; microbial biodiversity; abiotic and biotic stress mitigation; gene regulatory mechanisms; plant hormones in plant– microbe interactions; molecular mechanisms of plant growth and microbe interactions; chemical communication in plant– microbe interactions; microbe effects on fruit quality; OMICs approaches (metagenomics; metatranscriptomics; epigenomics; transcriptomics; metabolomics); bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Perspectives on Virus–Host Interactions
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 4186 | Submission Open
Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies
(This special issue belongs to the Section Molecular Microbiology)
Advancements in Alzheimer’s Disease Treatment: Exploring Novel Approaches and Strategies
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4184 | Submission Open
Keywords: Alzheimer’ s disease; bioinformatics; novel compounds; in vitro; in vivo; clinical study; Alzheimer’ s disease models
(This special issue belongs to the Section Molecular Neurobiology)
Recent Developments in Omics Technologies Applied to Oncology Research
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4173 | Submission Open
Keywords: single‑cell genome sequencing; single‑cell epigenome sequencing; single‑cell CRISPR sequencing; imaging mass cytometry; RNAscope; digital spatial profiling; multiplex IHC; multiplex IF; omics technologies
(This special issue belongs to the Section Molecular Oncology)
Endometriosis and Infertility
edited by Ludwig Kiesel
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4164 | Submission Open
Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Coronavirus Disease (COVID-19): Pathophysiology (6th Edition) submission deadline 20 Nov 2025 | 2 articles | Viewed by 4015 | Submission Open
Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Pathophysiology of Diabetes, Hypertension and Cardiovascular Diseases
edited by Alessandro Durante
submission deadline 20 Nov 2025 | 1 articles | Viewed by 3994 | Submission Open
Keywords: diabetes; hypertension; cardiology; cardiovascular diseases; coronary artery diseases; athero-sclerosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapeutic Targets for Neuroinflammation and Neurodegeneration
edited by Muhammad Sohail Khan and
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3984 | Submission Open
Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations
(This special issue belongs to the Section Molecular Neurobiology)
Involvement of Neuroinflammatory Processes in Psychiatric Conditions
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3981 | Submission Open
Keywords: neuroinflammation; glia; chemokine; cytokine; psychiatry disorder; motivation; learning; behavior; mental illness; psychopharmacology
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights in Antivirals and Vaccines submission deadline 20 Nov 2025 | 2 articles | Viewed by 3876 | Submission Open
Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants
(This special issue belongs to the Section Molecular Microbiology)
New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 3848 | Submission Open
Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics
(This special issue belongs to the Section Molecular Immunology)
Editorial Board Members’ Collection Series: “Protein Biophysics” submission deadline 20 Nov 2025 | 2 articles | Viewed by 3703 | Submission Open
Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms and New Markers of Cancer
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 3702 | Submission Open
Keywords: molecular pathology; molecular mechanisms; immunotherapy; cancer; oncology; pathology; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Lignocellulose Bioconversion and High-Value Utilization
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 3701 | Submission Open
Keywords: lignocellulosic biomass; including seed husks from grains; enzymes; microorganisms producing enzymes; chemical catalysts; biomass conversion; biofuels; bioproducts; fermentable sugars; biomass-based functional materials; lignocellulose nanoparticles
(This special issue belongs to the Section Macromolecules)
Genome Structure, Function and Dynamic Regulation of Cell Fate
edited by Georg Hildenbrand and
submission deadline 20 Nov 2025 | 1 articles | Viewed by 3680 | Submission Open
Keywords: genome structure and organization; DNA sequence patterning and functional genomics; epigenetic regulation and chromatin remodeling; DNA damage response and cellular developments; cellular differentiation and cell fate; transcriptional control; chromatin architecture
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Organic Synthesis in Drug Discovery submission deadline 20 Nov 2025 | 3 articles | Viewed by 3570 | Submission Open
Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Cognitive Dysfunction from COVID-19 Infection and Other Respiratory Viruses
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 3536 | Submission Open
Keywords: long COVID; post-COVID; cognitive dysfunction; virus; cognition; brain; viral infection; virol-ogy; RNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hematological Malignancies: Molecular Mechanisms and Therapy, 2nd Edition
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 3519 | Submission Open
Keywords: hematological malignancies; molecular pathways; genetics; immunopathogenesis; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Response to Drought, Heat, and Light Stress
edited by Mengzhu Lu and Shijiang Cao
submission deadline 20 Nov 2025 | 4 articles | Viewed by 3517 | Submission Open
Keywords: plant stress response; molecular biology techniques; bioinformatics; genetic mechanisms; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Genetic and Epigenetic Analyses in Cancer
edited by Jing Gong
submission deadline 20 Nov 2025 | 4 articles | Viewed by 3435 | Submission Open
Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer
(This special issue belongs to the Section Molecular Genetics and Genomics)
TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer submission deadline 20 Nov 2025 | 1 articles | Viewed by 3371 | Submission Open
Keywords: TGF-beta; fibrosis; inflammation; cancer; immune cells; fibroblasts; EMT; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Deciphering Molecular Complexity of Pancreatic Cancer submission deadline 20 Nov 2025 | 2 articles | Viewed by 3133 | Submission Open
Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Therapeutic Potential of Natural Compounds: Insights into Mechanisms, Molecular Docking, and Biological Activities, 2nd Edition submission deadline 20 Nov 2025 | 4 articles | Viewed by 3089 | Submission Open
Keywords: natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; therapeutic potential; anticancer; antimicrobial; antiviral; anti-civilization diseases; antiobesity; antidiabetes; preventing the development of cardiovascular diseases; including myocardial infarction; hypertension and ischemic heart disease; food hypersensitivity; antiallergy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Perspectives in Lung Diseases: Pathogenesis, Diagnosis, and Treatment
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2957 | Submission Open
Keywords: lung cancer models; cancer stem cells; tumor microenvironment; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2942 | Submission Open
Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets
edited by Jue Wang
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2940 | Submission Open
Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular Oncology)
Molecular Biology of Soybean
edited by Zhengjun Xia
submission deadline 20 Nov 2025 | 4 articles | Viewed by 2900 | Submission Open
Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances and Perspectives of Lung Disease: 2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2852 | Submission Open
Keywords: lung disease; inflammation; regeneration; infection; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products and Synthetic Compounds for Drug Development: 3rd Edition
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2845 | Submission Open
Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease
(This special issue belongs to the Section Molecular Pharmacology)
Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook
edited by Alfredo Cappariello
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2836 | Submission Open
Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Plant–Environment Interactions submission deadline 20 Nov 2025 | 1 articles | Viewed by 2775 | Submission Open
Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases
edited by and Anna Lass
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2698 | Submission Open
Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques
(This special issue belongs to the Section Molecular Microbiology)
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