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Molecular Insights in Antivirals and Vaccines

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 5894

Special Issue Editors


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Guest Editor
1. Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2. Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria
Interests: emerging viruses; vaccine design; antivirals; plant molecular farming; recombinant proteins; plant biotechnology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute of Molecular Biology and Biotechnologies (IMBB), Plovdiv, Bulgaria
Interests: systems biology; bioinformatics; plant and medical biotechnology; molecular farming
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Laboratory of Nutrigenomics, Functional Foods, and Nutraceuticals, Department of Biochemistry, Molecular Medicine, and Nutrigenomics, Medical University-Varna, Varna, Bulgaria
Interests: medicinal plants; bioactive compounds of plant origin; biological activity of plant components; polyphenols; in vitro and in vivo antioxidant, anti-inflammatory, and immunomodulatory properties of plant-derived products; molecular targets for natural bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We live in a highly dynamic epidemiological environment, with constantly changing viral pathogens spreading fast to new regions and hosts.   The most effective method to combat viral progression and to control as well as prevent epidemics among humans and animals is vaccination.  Smallpox was eradicated because of methodical and large-scale vaccination, which is also the reason for the recent advances towards the eradication of polio.  The constant progress in biotechnology, nanotechnology, cell cultures, plant molecular farming, and recombinant protein downstream processing helps us improve our current and generate new vaccine platforms that provide safer and more effective solutions for controlling emerging and reemerging viruses.  The development of nucleic-acid-based and nanoparticle vaccine technologies offers new approaches for rapid vaccine preparation, especially against the emergence of new viruses.

In addition, traditional herbal remedies and plant-derived bioactive metabolites can be a source of affordable new antiviral agents for anti-inflammatory and immunomodulatory therapy.

This Special Issue, “Molecular Insights in Antivirals and Vaccines”,  seeks all types of manuscripts (e.g., reviews, original research articles, and short communications) and aims to highlight recent developments in antiviral vaccine preparation in addition to applications of novel antiviral therapeutics derived from plants.  Manuscripts about molecular targets for plant-derived antiviral remedies are also welcomed.

Dr. Gergana Zahmanova
Prof. Dr. Ivan Minkov
Dr. Yoana Dimitrova Kiselova-Kaneva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new vaccine platforms
  • cell cultures
  • plant molecular farming
  • vaccines and VLPs
  • nanoparticle vaccines
  • emerging viral diseases
  • novel therapeutics
  • biologics
  • antibodies
  • receptor modulators
  • plant-based compounds with antiviral activity
  • medicinal plant-derived products
  • bioactive proteins from plants

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Published Papers (2 papers)

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Review

48 pages, 2454 KB  
Review
How Can Plant-Derived Natural Products and Plant Biotechnology Help Against Emerging Viruses?
by Gergana Zahmanova, Katerina Takova, Valeria Tonova, Ivan Minkov, Momchil Barbolov, Neda Nedeva, Deyana Vankova, Diana Ivanova, Yoana Kiselova-Kaneva and Georgi L. Lukov
Int. J. Mol. Sci. 2025, 26(15), 7046; https://doi.org/10.3390/ijms26157046 - 22 Jul 2025
Viewed by 2960
Abstract
Infectious diseases have been treated using plants and their compounds for thousands of years. This knowledge has enabled modern techniques to identify specific antiviral remedies and to understand their molecular mechanism of action. Numerous active phytochemicals, such as alkaloids, terpenoids, polyphenols (phenolic acids, [...] Read more.
Infectious diseases have been treated using plants and their compounds for thousands of years. This knowledge has enabled modern techniques to identify specific antiviral remedies and to understand their molecular mechanism of action. Numerous active phytochemicals, such as alkaloids, terpenoids, polyphenols (phenolic acids, flavonoids, stilbenes, and lignans), coumarins, thiophenes, saponins, furyl compounds, small proteins, and peptides, are promising options for treating and preventing viral infections. It has been shown that plant-derived products can prevent or inhibit viral entry into and replication by host cells. Biotechnological advances have made it possible to engineer plants with an increased capacity for the production and accumulation of natural antiviral compounds. Plants can also be engineered to produce various types of antivirals (cytokines, antibodies, vaccines, and lectins). This study summarizes the current understanding of the antiviral activity of specific plant-derived metabolites, emphasizing their mechanisms of action and exploring the enormous potential of plants as biological factories. Full article
(This article belongs to the Special Issue Molecular Insights in Antivirals and Vaccines)
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31 pages, 1683 KB  
Review
Strategic Advances in Targeted Delivery Carriers for Therapeutic Cancer Vaccines
by Junxi Wu, Jinghui Liang, Yuan Zhang, Chunyan Dong, Dejiang Tan, Hongyu Wang, Yiyang Zheng and Qing He
Int. J. Mol. Sci. 2025, 26(14), 6879; https://doi.org/10.3390/ijms26146879 - 17 Jul 2025
Cited by 1 | Viewed by 1418
Abstract
Cancer is one of the major global health burdens, and more effective treatments are needed. At present, there are surgery, targeted therapy, and immunotherapy for the treatment of tumors, but due to the limitations of diagnostic technology and drug resistance, surgery and targeted [...] Read more.
Cancer is one of the major global health burdens, and more effective treatments are needed. At present, there are surgery, targeted therapy, and immunotherapy for the treatment of tumors, but due to the limitations of diagnostic technology and drug resistance, surgery and targeted therapy have little effect. Active immunization in the field of immunotherapy can mobilize host immunity, trigger tumor-specific T-cell responses, and produce targeted cytotoxicity. Its efficacy largely depends on the targeted delivery efficiency of cancer vaccines. Although immunotherapy is more durable than other approaches, immunosuppression in the tumor microenvironment and immune evasion by malignant cells limit the therapeutic efficacy of cancer vaccines. To overcome these challenges, this review summarizes key strategies for improving vaccine vector targeting, as well as recent advances and trends in delivery systems. Full article
(This article belongs to the Special Issue Molecular Insights in Antivirals and Vaccines)
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