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Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis
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Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 3660

Special Issue Editor

Dr. Long Wu

E-Mail Website
Guest Editor
College of Food Science and Engineering, Hainan University, Haikou 570228, China
Interests: biosensors; functional nanomaterials; food safety; anlytical techniques; food analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague

The International Journal of Molecular Sciences is proud to introduce this Special Issue that aims to bring together the latest research findings, innovative approaches, and technological advancements in the field of analytical detection. This collection of peer-reviewed articles reflects the dynamic nature of molecular science and its application in creating more sensitive, accurate, and efficient detection methods.

With the rapid evolution of molecular biology, chemistry, and associated technologies, this Special Issue highlights the need for sensitive and precise detection methods that can keep pace with scientific discoveries. The articles included in this Special Issue present new methodologies and improvements upon existing ones, offering solutions to some of the most pressing challenges in molecular detection.

Scope of this Special Issue:

This Special Issue encompasses a wide array of topics, including but not limited to the following:

  1. Nanotechnology in Detection:the use of nanoparticles and nanosensors for the detection of biomolecules, toxins, and environmental pollutants.
  2. Bioanalytical Techniques:innovations in bioassays, immunoassays, and biosensors for monitoring biologically active compounds.
  3. Food Science: development of rapid, reliable tests for detecting residues, pathogens, and adulterants in food products.
  4. Clinical Diagnostics: novel diagnostic tools and techniques for early and precise detection of diseases at the molecular level, including DNA analysis and trace evidence detection.

We invite researchers, scientists, and scholars to contribute their original research, reviews, and perspectives to this Special Issue. Manuscripts should be submitted through the journal's online submission system and will undergo rigorous peer review. We welcome contributions that provide novel insights, innovative solutions, and significant advancements in the field of analytical detection for molecular sciences.

Dr. Long Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular detection
  • analytical techniques
  • nanosensors
  • food science
  • DNA analysis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

14 pages, 3156 KiB  
Article
Development of Sensitive R6G/AuNCs Ratiometric Fluorescent Probes for the Detection of Biogenic Amines in Fish Products
by Yutong Huang, Simiao Zhang, Mei Zhou, Xiaokang Xu, Weiqing Sun, Jing Ma and Long Wu
Int. J. Mol. Sci. 2025, 26(1), 139; https://doi.org/10.3390/ijms26010139 - 27 Dec 2024
Viewed by 654
Abstract
Biogenic amines (BAs), produced in fish and seafood due to microbial contamination, pose significant health risks. This study introduces a novel ratiometric fluorescent probe, synthesized by integrating rhodamine 6G(R6G) and gold nanoparticles (AuNCs), for the sensitive and specific detection of BAs. The probe [...] Read more.
Biogenic amines (BAs), produced in fish and seafood due to microbial contamination, pose significant health risks. This study introduces a novel ratiometric fluorescent probe, synthesized by integrating rhodamine 6G(R6G) and gold nanoparticles (AuNCs), for the sensitive and specific detection of BAs. The probe operates on the principle of BAs hydrolysis, catalyzed by diamine oxidase, to produce hydrogen peroxide (H2O2), which selectively quenches the fluorescence of AuNCs at 620 nm, while the fluorescence of R6Gat 533 nm remains unaffected. The ratio of I620/I553 demonstrated excellent linearity with a wide dynamic range (1–1000 μM) and a low detection limit of 0.1 μM. Validation using grass carp samples showed high recovery rates (97.57% to 104.29%), confirming the probe’s efficacy and potential for practical application in food safety monitoring. Full article
(This article belongs to the Special Issue Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis)
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19 pages, 2563 KiB  
Article
Effectively Enhancing the Physiological Activity and Sensory Quality of Whole Calamondin Puree via Yeast Fermentation
by Hongjian Zhang, Shuaiguang Liu, Zewei Ma, Huan Huang, Lianhe Zheng, Yan Tian and Qiuping Zhong
Int. J. Mol. Sci. 2024, 25(22), 11984; https://doi.org/10.3390/ijms252211984 - 7 Nov 2024
Cited by 1 | Viewed by 1184
Abstract
To explore the feasibility of pure yeast fermentation in whole Calamondin puree (FWCP) for the utilization of the whole fruit, yeasts were isolated from naturally fermented Calamondin, and their fermentation characteristics were evaluated. The results indicated that all yeasts were able to ferment [...] Read more.
To explore the feasibility of pure yeast fermentation in whole Calamondin puree (FWCP) for the utilization of the whole fruit, yeasts were isolated from naturally fermented Calamondin, and their fermentation characteristics were evaluated. The results indicated that all yeasts were able to ferment FWCP, reducing the sour taste by degrading citric acid, increasing the contents of nutrients (such as phenols and limonins) and volatile compounds, and enhancing the antioxidant activity and inhibition of α-glucosidase activity (p < 0.05). Among them, P. terricola QJJY1 and H. opuntiae QJJY14 exhibited stronger abilities to degrade organic acids, with P. terricola QJJY1 enhancing the antioxidant capacity by releasing phenolic compounds such as phloretin-3′,5′-di-c-β-glucoside, vitexin-2″-O-rhamnoside, and isomargaritene. Moreover, H. opuntiae QJJY15 improved the contents of characteristic volatile compounds such as terpene hydrocarbons and higher alcohols. In total, 70 components were identified as differential metabolites based on their fold change in the metabolites, with 42 differential metabolites involved in 29 metabolic pathways across four strains. The main pathways related to phenol and flavor enrichment were flavonoid, flavone, and flavonol biosynthesis, monoterpenoid biosynthesis, and glyoxylate and dicarboxylate metabolism. Therefore, yeast fermentation is an effective method for utilizing whole Calamondin. Full article
(This article belongs to the Special Issue Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis)
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12 pages, 2948 KiB  
Article
A Honeycomb Film Template-Based Method for High-Throughput Preparation of Anti-Salmonella typhimurium 14,028 Phage Microgels
by Jing Wu, Tingtao An, Yaxiong Song and Shuo Wang
Int. J. Mol. Sci. 2024, 25(22), 11911; https://doi.org/10.3390/ijms252211911 - 6 Nov 2024
Viewed by 964
Abstract
Developing efficient anti-microbials for thoroughly addressing Salmonella contamination is essential for the improvement of food safety. Phage-built materials have shown great potential for biocontrol in environments. Due to challenges in delivery and stability, their widespread use has remained unattainable. Here, we have developed [...] Read more.
Developing efficient anti-microbials for thoroughly addressing Salmonella contamination is essential for the improvement of food safety. Phage-built materials have shown great potential for biocontrol in environments. Due to challenges in delivery and stability, their widespread use has remained unattainable. Here, we have developed a honeycomb film template-based method for the high-throughput preparation of phage microgels. The honeycomb film template can be simply fabricated in a humid chamber based on a well-established breath figure method. The bacteriophage microgels can be further manufactured by dropping a pre-gelation solution containing bacteriophages into a honeycomb film template. This method can produce over 210,000 phage microgels in every square centimeter template with each microgel containing 1.04 × 107 phages. They can kill 99.90% of the contaminated S. typhimurium 14,028 on chicken samples. This simple, heat-free, and solvent-free method can maintain the strong anti-bacterial efficiency of phages, which can expand the wide application of phage-built microgels for food decontamination. Full article
(This article belongs to the Special Issue Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis)
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