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Microbiota and Cancer: 4th Edition
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Microbiota and Cancer: 4th Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 2414

Special Issue Editors

Dr. Silvia Turroni

E-Mail Website
Guest Editor
Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6-40126 Bologna, Italy
Interests: human microbiome; gut microbiome; microbial ecology; host–microbiome interactions; probiotics; next-generation sequencing
Special Issues, Collections and Topics in MDPI journals
Dr. Riccardo Masetti

E-Mail Website
Guest Editor
Pediatric Hematology-Oncology Unit, Department of Medical and Surgical Sciences DIMEC, University of Bologna, Bologna, Italy
Interests: acute myeloid leukemia in children; pediatric myelodysplastic syndrome; hematopoietic stem cell transplantation in children; next-generation sequencing; characterization and modulation of gut microbiota during hematopoietic stem cell transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human body is colonized by thousands of different microbial species that are essential to our survival. In the last 15 years, our knowledge of the human microbiome has increased exponentially. Thanks to next-generation DNA sequencing, metabolomics, and genobiotic models, we can dissect compositional and functional microbiome structures and elucidate the mechanisms underlying the role of the microbiome in human biology and pathology. Mounting evidence has suggested a critical role of the microbiome in host immune responses, specifically the host’s susceptibility to cancer and their response to cancer treatment. The impact of the gut microbiota on anticancer immune responses has represented an intriguing and evolving area of exploration in the recent literature. Novel metacommunity approaches have provided an integrative and extensive understanding of the tight link between the microbiome and cancer, and have offered new, exciting insights into possible therapeutic avenues.

This Special Issue titled “Microbiota and Cancer 4.0” will focus on the role of the human microbiome in the pathogenesis of cancer, in the host response to immunotherapy, in hematopoietic stem cell transplantation, and in possible microbiota-based therapeutic or pre-emptive strategies to manage treatment-related complications.

Authors are invited to submit original research articles and review papers which address the abovementioned topics in this Special Issue.

Dr. Silvia Turroni
Dr. Riccardo Masetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • cancer
  • hematopoietic stem cell transplantation
  • human microbiome
  • immune system
  • colon cancer
  • carcinogenesis
  • nutrition
  • short-chain fatty acids
  • metagenomic
  • dysbiosis

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Published Papers (2 papers)

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19 pages, 8468 KiB  
Article
Differential Urinary Microbiome and Its Metabolic Footprint in Bladder Cancer Patients Following BCG Treatment
by Kyungchan Min, Chuang-Ming Zheng, Sujeong Kim, Hyun Kim, Minji Lee, Xuan-Mei Piao, Young Joon Byun, Yunjae Kim, Yanghyun Joo, Beomki Cho, Seongmin Moon, Won Tae Kim, Ho Won Kang, Hansoo Park and Seok Joong Yun
Int. J. Mol. Sci. 2024, 25(20), 11157; https://doi.org/10.3390/ijms252011157 - 17 Oct 2024
Cited by 1 | Viewed by 1557
Abstract
Recent studies have identified a urinary microbiome, dispelling the myth of urine sterility. Intravesical bacillus Calmette–Guérin (BCG) therapy is the preferred treatment for intermediate to high-risk non-muscle-invasive bladder cancer (BCa), although resistance occurs in 30–50% of cases. Progression to muscle-invasive cancer necessitates radical [...] Read more.
Recent studies have identified a urinary microbiome, dispelling the myth of urine sterility. Intravesical bacillus Calmette–Guérin (BCG) therapy is the preferred treatment for intermediate to high-risk non-muscle-invasive bladder cancer (BCa), although resistance occurs in 30–50% of cases. Progression to muscle-invasive cancer necessitates radical cystectomy. Our research uses 16S rRNA gene sequencing to investigate how the urinary microbiome influences BCa and its response to BCG therapy. Urine samples were collected via urethral catheterization from patients with benign conditions and non-muscle-invasive BCa, all of whom underwent BCG therapy. We utilized 16S rRNA gene sequencing to analyze the bacterial profiles and metabolic pathways in these samples. These pathways were validated using a real metabolite dataset, and we developed predictive models for malignancy and BCG response. In this study, 87 patients participated, including 29 with benign diseases and 58 with BCa. We noted distinct bacterial compositions between benign and malignant samples, indicating the potential role of the toluene degradation pathway in mitigating BCa development. Responders to BCG had differing microbial compositions and higher quinolone synthesis than non-responders, with two Bifidobacterium species being prevalent among responders, associated with prolonged recurrence-free survival. Additionally, we developed highly accurate predictive models for malignancy and BCG response. Our study delved into the mechanisms behind malignancy and BCG responses by focusing on the urinary microbiome and metabolic pathways. We pinpointed specific beneficial microbes and developed clinical models to predict malignancy and BCG therapy outcomes. These models can track recurrence and facilitate early predictions of treatment responses. Full article
(This article belongs to the Special Issue Microbiota and Cancer: 4th Edition)
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Review

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19 pages, 529 KiB  
Review
Vaginal Microbiota and Local Immunity in HPV-Induced High-Grade Cervical Dysplasia: A Narrative Review
by Helena C. J. Schellekens, Lotte M. S. Schmidt, Servaas A. Morré, Edith M. G. van Esch and Peggy J. de Vos van Steenwijk
Int. J. Mol. Sci. 2025, 26(9), 3954; https://doi.org/10.3390/ijms26093954 - 22 Apr 2025
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Abstract
Persistent high-risk Human Papillomavirus infection is the primary factor in cervical carcinogenesis. However, other host-related features are believed to play a role as well. Recent research suggests that the vaginal microbiome and the immune microenvironment play a significant role in the acquisition and [...] Read more.
Persistent high-risk Human Papillomavirus infection is the primary factor in cervical carcinogenesis. However, other host-related features are believed to play a role as well. Recent research suggests that the vaginal microbiome and the immune microenvironment play a significant role in the acquisition and persistence of Human Papillomavirus infection, as well as in the regression or progression of cervical intraepithelial lesions. Studies in this emerging field describe factors associated with this interaction, though the precise nature remains incompletely understood. In this narrative review, we aim to summarize the current literature on the topic and propose hypotheses and recommendations for future research and treatment strategies. Full article
(This article belongs to the Special Issue Microbiota and Cancer: 4th Edition)
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