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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Intestinal Microbiome and Its Function

edited by

Simone Baldi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1111 | Submission Open

Keywords: human microbiome; gut microbiome; microbiota-derived metabolites; SCFAs; gut– organ axis

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research of Natural Products in Cancer Diseases

edited by

Angeliki Tiptiri-Kourpeti

submission deadline 20 Sep 2025 | Viewed by 1062 | Submission Open

Keywords: cancer; natural products; drug resistance; side effects; bioactive compounds; prevention; treatment; signaling pathways; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1037 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research on Female Reproductive Physiology

edited by Tomoko Fujiwara and

Masanori Ono

submission deadline 20 Sep 2025 | 1 articles | Viewed by 976 | Submission Open

Keywords: circadian rhythm; diet; hypothalamus; lifestyle habits; ovary; pituitary; preconception care; reproduction function; reproductive behavior; uterus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry

edited by Łukasz Huminiecki

submission deadline 20 Sep 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: multi-omics; statistics; gene expression analysis

(This special issue belongs to the Section Molecular Informatics)

3D Technology in Biomedicine: Studying Molecular Mechanisms in Health and Disease

edited by Flavia Carton

submission deadline 20 Sep 2025 | 1 articles | Viewed by 957 | Submission Open

Keywords: 3D technologies; biomedicine; molecular biology; in vitro/ex vivo models; regenerative medicine; human diseases

(This special issue belongs to the Section Materials Science)

Personalized Nanomedicine in Oncology

edited by Sajid Ali

submission deadline 20 Sep 2025 | Viewed by 934 | Submission Open

Keywords: drug/gene delivery; biomaterials; stimuli-responsive systems; lipid– polymer nanoparticles; lipodendriplexes; dual delivery; inorganic nanoparticles; targeted delivery system

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 20 Sep 2025 | 1 articles | Viewed by 932 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Nanostructures: From Synthesis, Modification to Biomedical Applications

edited by Kleoniki Giannousi and

Catherine Dendrinou-Samara

submission deadline 20 Sep 2025 | 1 articles | Viewed by 920 | Submission Open

Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors

(This special issue belongs to the Section Molecular Nanoscience)

Plant Breeding and Genetics: New Findings and Perspectives

edited by

Andrés J. Cortés

submission deadline 20 Sep 2025 | 2 articles | Viewed by 917 | Submission Open

Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

miRNAs in Cancers: From Molecular Biology to Treatment

edited by

Laura Mosca

submission deadline 20 Sep 2025 | 1 articles | Viewed by 902 | Submission Open

Keywords: cancer; miRNA; epigenetic

(This special issue belongs to the Section Molecular Biology)

Recent Research of Protein Structure Prediction and Design

edited by

Alexandre G. De Brevern

submission deadline 20 Sep 2025 | 1 articles | Viewed by 860 | Submission Open

Keywords: protein design; multidomain proteins; AlphaFold2; protein folding; deep learning

(This special issue belongs to the Section Biochemistry)

Extracellular Vesicles: Functions and Therapeutic Applications

edited by Deepshikha Tewari

submission deadline 20 Sep 2025 | Viewed by 848 | Submission Open

Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases

(This special issue belongs to the Section Molecular Biology)

Nanotechnology and Nanomedicine: Approaches, Challenges and Translation for Tissue Regeneration

edited by

Dinesh Kumar Srinivasan

submission deadline 20 Sep 2025 | 1 articles | Viewed by 811 | Submission Open

Keywords: nanotechnology; bone regeneration; skin regeneration; cardiac tissue regeneration; brain tissue regeneration; drug delivery system; targeted therapy

(This special issue belongs to the Section Molecular Nanoscience)

Host-Pathogen Interactions during Persistent Bacterial Infections, 2nd Edition

edited by

Bettina Löffler

submission deadline 20 Sep 2025 | 1 articles | Viewed by 776 | Submission Open

Keywords: bacteria; intracellular adaptation; metabolic adaptation; metabolic host reprogramming; host– pathogen interaction; chronic infections; regulation of virulence

(This special issue belongs to the Section Molecular Microbiology)

Genetic and Epigenetic Insights into Extracellular Vesicles

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Sep 2025 | Viewed by 749 | Submission Open

Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology

(This special issue belongs to the Section Biochemistry)

Emerging Topics in Macromolecular Crystallography

edited by

Zhongzhou Chen

and

Giuseppe Zanotti

submission deadline 20 Sep 2025 | 1 articles | Viewed by 723 | Submission Open

Keywords: macromolecular crystallography; structural biology; artificial intelligence; structure determination; molecular mechanism; functions; drug discovery; protein; nucleic acid; carbohydrates

(This special issue belongs to the Section Macromolecules)

Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond

edited by

Jian Zhang

and

Michael Deyholos

submission deadline 20 Sep 2025 | 1 articles | Viewed by 713 | Submission Open

Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants

(This special issue belongs to the Section Molecular Plant Sciences)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 20 Sep 2025 | 1 articles | Viewed by 698 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Cell Biology and Biochemistry Regulation Mediated by Natural Compounds

edited by

Amélia M. Silva

submission deadline 20 Sep 2025 | Viewed by 685 | Submission Open

Keywords: cellular targets; natural compounds; nutraceuticals; health-promoting effects; enzymatic activity; cell-based assays; in vivo; nanoencapsulation; delivery of natural compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Research Progresses on Multifaceted Cholinergic Signaling

edited by Taher Darreh-Shori

submission deadline 20 Sep 2025 | Viewed by 677 | Submission Open

Keywords: cholinergic signaling; choline acetyltransferase (ChAT); nicotinic acetylcholine receptors (AChRs); muscarinic acetylcholine receptors (mAChRs); mitochondrial acetylcholine receptors; cholinergic anti-inflammatory pathway; cholinergic signaling in cancer; cholinergic signaling in mitochondria; cholinergic signaling in ALS; cholinergic signaling in dementia; cholinergic signaling in COVID-19

(This special issue belongs to the Section Molecular Neurobiology)

Application of Mass Spectrometry and Chromatography in Drug Monitoring

edited by Carsten Müller

submission deadline 20 Sep 2025 | 1 articles | Viewed by 646 | Submission Open

Keywords: therapeutic drug monitoring; method validation; pharmacometrics; pediatric clinical pharmacology; laboratory developed tests; clinical mass spectrometry; functional tests; isobars; triple quad mass spectrometry; HR-MS; biomarker; drugs of abuse; therapeutic drugs; metabolites

(This special issue belongs to the Section Biochemistry)

Red Blood Cell Dysfunction and Hemodynamic Changes in Inflammation, Infection and Metabolic Disease

edited by Janette Bester

submission deadline 20 Sep 2025 | 1 articles | Viewed by 630 | Submission Open

Keywords: red blood cell; inflammation; infection; metabolic disease; hemodynamics

(This special issue belongs to the Section Molecular Biology)

Role of Natural Products in Human Health and Disease

edited by

Sung-Joon Lee

and Ji Hae Lee

submission deadline 20 Sep 2025 | 1 articles | Viewed by 622 | Submission Open

Keywords: natural substances; phytochemicals; chronic diseases; aging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs

edited by

Daekyu Sun

submission deadline 20 Sep 2025 | 1 articles | Viewed by 608 | Submission Open

Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Natural Products in Inflammation

edited by

Antonia Cianciulli

submission deadline 20 Sep 2025 | 1 articles | Viewed by 601 | Submission Open

Keywords: inflammation; natural products; immunomodulation; bioactive compounds; drug discovery; drug target identification; anti-inflammatory activity; antioxidant activity; cellular signalling pathways

(This special issue belongs to the Section Molecular Pharmacology)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 Sep 2025 | 1 articles | Viewed by 591 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Compounds from Foods Against Diseases

edited by Jongbin Lim

submission deadline 20 Sep 2025 | 1 articles | Viewed by 581 | Submission Open

Keywords: diet-related diseases; bioactive compounds; analytical techniques; functional foods; molecular interaction; health benefits

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 20 Sep 2025 | 1 articles | Viewed by 558 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

Roles and Function of Extracellular Vesicles in Diseases: 3rd Edition

edited by

Won Jong Rhee

submission deadline 20 Sep 2025 | Viewed by 550 | Submission Open

Keywords: extracellular vesicle; exosome; disease; roles and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Macrophage Biology to Cell and EV-Based Immunotherapies

edited by

Katarzyna Nazimek

and

Krzysztof Bryniarski

submission deadline 20 Sep 2025 | 1 articles | Viewed by 515 | Submission Open

Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 20 Sep 2025 | Viewed by 514 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Lipoproteins—Opportunities for the Development of Nanotherapeutics in Chronic Disease

edited by

Thomas Grewal

submission deadline 20 Sep 2025 | Viewed by 497 | Submission Open

Keywords: lipoproteins; LDL; HDL; nanotherapeutics; chronic disease; targeted therapy; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Medicinal Mechanism and Application of Biologically Active Compounds in Melanoma

edited by Rosanna Avola and Adriana C. E. Graziano

submission deadline 20 Sep 2025 | Viewed by 493 | Submission Open

Keywords: biologically active compounds; medicinal mechanism; cancer; melanoma; chemoprevention; anticancer effect; immunomodulation; apoptosis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Chemicals Impacts on the Reproductive System

edited by

Giovanna Liguori

and

Anna Costagliola

submission deadline 20 Sep 2025 | Viewed by 476 | Submission Open

Keywords: endocrine disruptors; environmental pollution; female reproduction; male reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 474 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Novel Therapeutic Advances in Pancreatic Cancer

edited by

Enza Lonardo

submission deadline 20 Sep 2025 | Viewed by 471 | Submission Open

Keywords: pancreatic cancer; therapeutic advancements; tumor microenvironment; personalized medicine; biomarkers; liquid biopsy; targeted therapies; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

The Role of Choroid Plexus in Neurological Health

edited by

Telma Quintela

submission deadline 20 Sep 2025 | Viewed by 470 | Submission Open

Keywords: choroid plexus; cerebrospinal fluid; neurological health; blood– CSF barrier; central nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Epilepsy and Antiepileptic Drugs, 3rd Edition

edited by

Jarogniew J. Luszczki

submission deadline 20 Sep 2025 | Viewed by 458 | Submission Open

Keywords: antiepileptic drugs: classic; novel; second and third generations; antiseizure medications: novel therapeutic options; cannabinoids in epilepsy; animal models of epilepsy: from animals to humans; clinical trials in epilepsy: novel potentially efficacious drugs; interactions between antiepileptic drugs: pharmacodynamic and pharmacokinetic aspects; interactions of antiepileptic drugs with other drugs: pharmacodynamic and pharmacokinetic aspects; adverse effects of antiseizure medication; treatment of epilepsy in specific populations (elderly; childbearing women; children); drug-resistant epilepsy in preclinical conditions; epileptogenesis: all pathophysiological and molecular aspects

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research of Human Fertility

edited by

Angeliki Tiptiri-Kourpeti

and Byron Asimakopoulos

submission deadline 20 Sep 2025 | Viewed by 450 | Submission Open

Keywords: human reproduction; fertility preservation; ART; infertility; IVF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Transplantation and Machine Perfusion

edited by

Joan Roselló-Catafau

and

Arnau Panisello-Roselló

submission deadline 20 Sep 2025 | Viewed by 434 | Submission Open

Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Biomarkers in Pancreatic Diseases

edited by

Laura Gaman

and

Mihaela Badea

submission deadline 20 Sep 2025 | Viewed by 429 | Submission Open

Keywords: pancreatic disease; pancreatic cancer; pancreatitis; biomarker; RNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms, Emerging Biomarkers, Novel Therapies and Personalized Treatment in Celiac Disease (CD)

edited by María Isabel Torres

submission deadline 20 Sep 2025 | Viewed by 412 | Submission Open

Keywords: celiac disease; gluten sensitivity; immune response; emerging biomarkers; novel therapies; microbiome modulation; personalized treatment

(This special issue belongs to the Section Molecular Immunology)

Antimicrobial Agents: Synthesis and Design

edited by

Silvana Alfei

submission deadline 20 Sep 2025 | Viewed by 401 | Submission Open

Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles

(This special issue belongs to the Section Molecular Microbiology)

Natural Compounds for Skeletal Muscle Health and Regeneration

edited by

Khurshid Ahmad

submission deadline 20 Sep 2025 | Viewed by 394 | Submission Open

Keywords: skeletal muscle; natural compounds; molecular mechanism; muscle regeneration; computational analysis; experimental analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Progress in Extracellular Vesicles

edited by

Regina Golan-Gerstl

submission deadline 20 Sep 2025 | Viewed by 390 | Submission Open

Keywords: extracellular vesicles (EVs); macrovesicles; exosomes; cell– cell comunication

(This special issue belongs to the Section Molecular Biology)

Advances in Bioactive Peptides: Mechanisms of Action and Biosynthesis

edited by

Eduardo Costa

and

Sara Nunes Silva

submission deadline 20 Sep 2025 | Viewed by 387 | Submission Open

Keywords: mechanisms of action; biosynthesis; bioactive peptides (BAPs); innate immunity; synthetic peptides; therapeutic applications; antimicrobial peptides (AMPs)

(This special issue belongs to the Section Biochemistry)

Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

edited by

Oriana Trubiani

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Sep 2025 | Viewed by 383 | Submission Open

Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Major Histocompatibility Complex Antigens in Disease

edited by Jerzy K. Kulski and Charles E. Larsen

submission deadline 20 Sep 2025 | Viewed by 381 | Submission Open

Keywords: major histocompatibility complex; immune response; human leukocyte antigen (HLA); immune function; disease susceptibility; pathogen resistance; antigenic transposable elements; cancer

(This special issue belongs to the Section Molecular Immunology)

Epigenetics of Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 20 Sep 2025 | Viewed by 381 | Submission Open

Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 751-800 on page 16 of 68.

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