Intestinal Microbiome and Its Function
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 619
Special Issue Editor
Special Issue Information
Dear Colleagues,
The human microbiome encompasses a vast community of trillions of microorganisms, including bacteria, viruses, and fungi, that inhabit different regions of the body such as the gut, skin, mouth, and genitals. Of these, the gut microbiome is the most extensively studied due to its profound influence on overall health. An imbalance in these microbial communities, known as dysbiosis, has been linked to numerous health conditions, including obesity, diabetes, inflammatory bowel disease, allergies, and neurological disorders. Key metabolites derived from the gut microbiota, such as short-chain fatty acids (SCFAs), bile acids, tryptophan-derived compounds, and trimethylamine N-oxide (TMAO), play crucial roles in regulating metabolism, immune function, and even mental health. The microbiota–gut–organ axis refers to the complex communication network between the gut microbiota and various organs, illustrating how gut microbes’ impact not only the gastrointestinal system but also critical organs such as the brain, liver, lungs, heart, and immune system.
Based on these premises, the aims of this Special Issue are to underscore the pivotal role of the human microbiota in maintaining physiological balance, explore how disruptions in microbial networks contribute to the development of various diseases, and examine strategies for restoring a healthy microbiome through targeted interventions.
Dr. Simone Baldi
Guest Editor
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Keywords
- human microbiome
- gut microbiome
- microbiota-derived metabolites
- SCFAs
- gut–organ axis
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