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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Antioxidant Activity
edited by Agnieszka Filipek
submission deadline 20 Jun 2026 | Viewed by 176 | Submission Open
Keywords: antioxidants; advanced mechanisms of action; signaling pathways; molecular mechanism; biologically active compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cellular Mechanisms of Pulmonary Arterial Hypertension
edited by and Saurabh Aggarwal
submission deadline 20 Jun 2026 | Viewed by 174 | Submission Open
Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research in Alzheimer’s Disease: From Pathology to Therapy
edited by Sofía Yolanda Díaz Miranda
submission deadline 20 Jun 2026 | Viewed by 166 | Submission Open
Keywords: multifunctional compounds in Alzheimer’ s disease therapy; translational medicine in Alzheimer's disease; novel drug candidates for Alzheimer's disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Molecular Mechanisms of Prostate Cancer
edited by
submission deadline 20 Jun 2026 | Viewed by 166 | Submission Open
Keywords: genetic alterations; signlaing pathways; cellular dysregulation; non-coding RNAs; epigenetics; tumor microenvironment; metabolic factors; therapuetic targeting; multi-modal approaches
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Biotic and Abiotic Stress Responses in Trees
edited by
submission deadline 20 Jun 2026 | Viewed by 165 | Submission Open
Keywords: drought stress; nutrient deficiency; salinity stress; pathogen defense; transcriptional regulation; epigenetic modifications; signal transduction; bioinformatics & multi-omics analysis; breeding for stress resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Interstitial Lung Diseases: From Molecular Pathology to New Treatments
edited by
submission deadline 20 Jun 2026 | Viewed by 162 | Submission Open
Keywords: interstitial lung diseases (ILDs); therapeutic strategies; molecular pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Acute Lung Injury
edited by
submission deadline 20 Jun 2026 | Viewed by 160 | Submission Open
Keywords: acute lung injury; ARDS; primary graft dysfunction; immune cells; neutrophils; pulmonary edema; alveolar epithelium; lung endothelium
(This special issue belongs to the Section Molecular Immunology)
New Trends in Green Synthesis of Nanomaterials
edited by Rocío Redón
submission deadline 20 Jun 2026 | Viewed by 160 | Submission Open
Keywords: nanoparticles; cytotoxicity; drug delivery; nanomaterials; green synthesis
(This special issue belongs to the Section Molecular Nanoscience)
Recent Advances in Genome-Edited Animal Models
edited by Takayuki Sakurai and
submission deadline 20 Jun 2026 | Viewed by 157 | Submission Open
Keywords: genome editing; prime editing; base editing; CRISPRa/CRISPRi; knock-in/out; conditional genome editing; multiplex genome editing; manipulation of early embryos and germ cells; in vivo gene delivery; genome-edited animals; disease animal model
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insights into Mechanobiology of Regeneration
edited by and Timothy R. Deer
submission deadline 20 Jun 2026 | Viewed by 156 | Submission Open
Keywords: mechanotransduction; regeneration; stem cells; extracellular matrix; tissue repair
(This special issue belongs to the Section Molecular Biophysics)
Molecular Insights into Skin Health and Disease
edited by Federica Li Pomi
submission deadline 20 Jun 2026 | Viewed by 156 | Submission Open
Keywords: dermatology; molecular mechanisms; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Genetics and Precision Breeding of Tomato
edited by Younghoon Park
submission deadline 20 Jun 2026 | Viewed by 155 | Submission Open
Keywords: climate change; gene editing; genomic selection; flavor; functional compounds; molecular marker; omics; precision breeding; Solanum lycopersicum; tomato
(This special issue belongs to the Section Molecular Plant Sciences)
New Perspectives in Protein Structure
edited by
submission deadline 20 Jun 2026 | Viewed by 154 | Submission Open
Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins
(This special issue belongs to the Section Molecular Biophysics)
Recent Advances in Computer-Aided Drug Design
edited by
submission deadline 20 Jun 2026 | Viewed by 154 | Submission Open
Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning
(This special issue belongs to the Section Molecular Pharmacology)
Recombinant Proteins and Antibody Engineering for Diagnostic and Treatment of Emerging Infectious Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 147 | Submission Open
Keywords: recombinant proteins; antibody engineering; monoclonal antibodies; hemorrhagic fevers; tuberculosis; emerging infectious diseases; neglected viruses; diagnostics; therapeutic antibodies
(This special issue belongs to the Section Molecular Immunology)
Gene Regulation in Endocrine Disease, 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 140 | Submission Open
Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Genetic Susceptibility in Human Diseases
edited by Xiaowu Gai
submission deadline 20 Jun 2026 | Viewed by 137 | Submission Open
Keywords: bioinformatics; genomics; genetic susceptibility to disease; genetic variation; gene– environment interactions; biomarkers; epigenetic mechanisms; pharmacogenomics; population genetics; bioinformatics tools and databases; novel diagnostics; targeted therapies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses, and Therapeutic
edited by Magdalena Wawrzyńska
submission deadline 20 Jun 2026 | Viewed by 135 | Submission Open
Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound
edited by Alicia Paz
submission deadline 20 Jun 2026 | Viewed by 135 | Submission Open
Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives
(This special issue belongs to the Section Molecular Microbiology)
Molecular Crosstalk in Stress-Induced Psychopathology
edited by Ilaria Demori and
submission deadline 20 Jun 2026 | Viewed by 131 | Submission Open
Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota– gut– brain axis; Blood– brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 129 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling
(This special issue belongs to the Section Molecular Biology)
Nanobiotechnology: Breaking Barriers in Phytomedicine submission deadline 20 Jun 2026 | Viewed by 128 | Submission Open
Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products
(This special issue belongs to the Section Molecular Nanoscience)
Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration
edited by Seema Singh
submission deadline 20 Jun 2026 | Viewed by 125 | Submission Open
Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections
(This special issue belongs to the Section Molecular Immunology)
From Discovery to Clinic: Overcoming Barriers in Antimicrobial Peptide Development
edited by José M. Pérez De la Lastra
submission deadline 20 Jun 2026 | Viewed by 125 | Submission Open
Keywords: antimicrobial peptides (AMPs); translational challenges; in vivo efficacy; drug delivery and formulation; computational approaches; pharmacokinetics; toxicity prediction; antibiotic resistance; animal models; nanotechnology
(This special issue belongs to the Section Molecular Microbiology)
Epigenetic Alterations in Hepatocellular Carcinoma
edited by
submission deadline 20 Jun 2026 | Viewed by 125 | Submission Open
Keywords: hepatocellular carcinoma (HCC); epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs epigenetic biomarkers; cancer progression
(This special issue belongs to the Section Molecular Oncology)
Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease
edited by Alessandra Porcu
submission deadline 20 Jun 2026 | Viewed by 122 | Submission Open
Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders
edited by
submission deadline 20 Jun 2026 | Viewed by 122 | Submission Open
Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support
edited by
submission deadline 20 Jun 2026 | Viewed by 111 | Submission Open
Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine
(This special issue belongs to the Section Molecular Informatics)
Molecular and Adaptive Mechanisms in Plant Genetics
edited by
submission deadline 20 Jun 2026 | Viewed by 104 | Submission Open
Keywords: forest genetics; breeding techniques; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity
edited by Bourlaye Fofana and
submission deadline 20 Jun 2026 | Viewed by 94 | Submission Open
Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity
(This special issue belongs to the Section Molecular Plant Sciences)
Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease submission deadline 20 Jun 2026 | Viewed by 31 | Submission Open
Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 21 | Submission Open
Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents
(This special issue belongs to the Section Molecular Microbiology)
New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 19 | Submission Open
Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling
(This special issue belongs to the Section Molecular Immunology)
Functions and Applications of Natural Products: 2nd Edition
edited by
submission deadline 25 Jun 2026 | 1 articles | Viewed by 498 | Submission Open
Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Pregnancy-Related Complications
edited by Kallirhoe Kalinderi
submission deadline 25 Jun 2026 | Viewed by 234 | Submission Open
Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)
edited by
submission deadline 25 Jun 2026 | Viewed by 98 | Submission Open
Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Function in Human Health and Disease: 3rd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 76 | Submission Open
Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT
(This special issue belongs to the Section Biochemistry)
Molecular Progression of Gut Microbiota—2nd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 68 | Submission Open
Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis
(This special issue belongs to the Section Molecular Microbiology)
Current Research on Cancer Biology and Therapeutics: Fourth Edition submission deadline 29 Jun 2026 | 4 articles | Viewed by 1744 | Submission Open
Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists
(This special issue belongs to the Section Molecular Oncology)
Plant Growth: Molecular Mechanisms submission deadline 29 Jun 2026 | Viewed by 5 | Submission Open
Keywords: plant growth; hormonal crosstalk; epigenetics; CRISPR/Cas9 genome editing technologies; metabolomics; transcriptomics
(This special issue belongs to the Section Molecular Plant Sciences)
State-of-the-Art Molecular Immunology in Chile, 2nd Edition submission deadline 30 Jun 2026 | 7 articles | Viewed by 14972 | Submission Open
Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile
(This special issue belongs to the Section Molecular Immunology)
Wnt/β-Catenin Signaling in Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 6554 | Submission Open
Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 6291 | Submission Open
Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Preclinical and Translational Research in Thyroid Cancer submission deadline 30 Jun 2026 | 2 articles | Viewed by 5786 | Submission Open
Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Natural Products for Cancer Therapy
edited by María Jesus Rodríguez-Yoldi
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3310 | Submission Open
Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections submission deadline 30 Jun 2026 | 1 articles | Viewed by 2888 | Submission Open
Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Endocrine Regulation in Health and Diseases
edited by Fady Hannah-Shmouni
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2526 | Submission Open
Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Hormone Receptor in Breast Cancer: 2nd Edition submission deadline 30 Jun 2026 | 2 articles | Viewed by 2492 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Oncology)
Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies
edited by Sukkum Ngullie Chang and Vernat Exil
submission deadline 30 Jun 2026 | Viewed by 489 | Submission Open
Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Regulation of Plant Growth and Protection (2nd Edition)
edited by and
submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open
Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions
(This special issue belongs to the Section Molecular Plant Sciences)
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