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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms

edited by

Tosin Olasehinde

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2745 | Submission Open

Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory

(This special issue belongs to the Section Molecular Toxicology)

The Role of Thyroid Hormone in Health and Disease

edited by Sandra Incerpi and Jens Z. Pedersen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2695 | Submission Open

Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Genetics and Breeding for Sugar Crops

edited by Muqing Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2630 | Submission Open

Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene

(This special issue belongs to the Section Molecular Plant Sciences)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2586 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases

edited by

Takuro Miyazaki

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2561 | Submission Open

Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase

(This special issue belongs to the Section Molecular Biology)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2516 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Challenges in Molecularly Imprinted Materials

edited by

Monika Sobiech

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2499 | Submission Open

Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization

(This special issue belongs to the Section Materials Science)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2496 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Rhizobia

edited by

Socorro Mesa

, María J. Delgado and

Germán Tortosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2381 | Submission Open

Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis

(This special issue belongs to the Section Molecular Microbiology)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2235 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress and Mitochondria in Human Diseases

edited by

Alejandra Espinosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2214 | Submission Open

Keywords: mitochondrial dynamics; ROS; antioxidants; mitophagy; oxidative damage; lipid peroxidation; neurodegenerative diseases; cancer; obesity

(This special issue belongs to the Section Biochemistry)

Molecular Research of Abiotic Stress in Plants

edited by Deguo Han

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2096 | Submission Open

Keywords: abiotic stress; salt stress; drought stress; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Gastrointestinal Cancer, 3rd Edition

edited by

Aneta Koronowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2017 | Submission Open

Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease

edited by

Alberto Ouro

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2009 | Submission Open

Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair

edited by Anisa Shaker

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2001 | Submission Open

Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Treatment of Neurodegenerative Diseases with Natural Products

edited by

Eugene Huh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1990 | Submission Open

Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antimicrobial Peptides in Reproductive Health and Disease

edited by

Ga-Hyun Son

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1985 | Submission Open

Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition

edited by

Anna D. Kozhevnikova

and

Ilya Vladimirovich Seregin

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1874 | Submission Open

Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis

(This special issue belongs to the Section Molecular Plant Sciences)

Sleep and Breathing: From Molecular Perspectives

edited by Alberto Alonso-Fernández

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1724 | Submission Open

Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics

(This special issue belongs to the Section Molecular Biology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1718 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

Recent Research in Probiotic Yeasts: Molecular Aspects

edited by

Maurizio Ciani

and

Francesca Comitini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1711 | Submission Open

Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Photosystem I (Second Edition)

edited by

Stefano Santabarbara

and

Gary Hastings

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1709 | Submission Open

Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Intestinal Diseases and Gut Microbiota

edited by

Anna Duda-Madej

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1675 | Submission Open

Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing

edited by

Mun Bong-Gyu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1637 | Submission Open

Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine

edited by

Tomasz Urbanowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1614 | Submission Open

Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1597 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

New Insights into Anticancer Strategies

edited by

Yong Teng

submission deadline 20 Dec 2025 | Viewed by 1584 | Submission Open

Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Biocomposite Hydrogels for Biomedical Applications

edited by

Leonard Ionut Atanase

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1581 | Submission Open

Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing

(This special issue belongs to the Section Materials Science)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1575 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Epilepsy: From Molecular Basis to Therapy, 2nd Edition

edited by

Henry Hing Cheong Lee

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1538 | Submission Open

Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Ion Channels in Human Health and Diseases

edited by

Sheng-Nan Wu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1497 | Submission Open

Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology

(This special issue belongs to the Section Molecular Biology)

Insights into Functional Nanomaterials: Application-Related Structural Analysis

edited by Zoltán Dudás

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1471 | Submission Open

Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Virus-Host Immune Interactions

edited by

Claudia Vanetti

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1400 | Submission Open

Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2

(This special issue belongs to the Section Molecular Immunology)

Neural Stem Cells: Latest Applications and Future Perspectives

edited by

Evangelos Delivopoulos

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1394 | Submission Open

Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Plant Reproductive Development

edited by Zsolt Pónya and

Iman Mirmazloum

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1379 | Submission Open

Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1370 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

The Role of Non-Coding RNAs in Female Reproduction

edited by

Angela Caponnetto

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1335 | Submission Open

Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network

(This special issue belongs to the Section Molecular Genetics and Genomics)

Regulatory Mechanisms Underlying Tumorigenesis

edited by

Kazuhiko Kuwahara

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1256 | Submission Open

Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models

(This special issue belongs to the Section Molecular Oncology)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 20 Dec 2025 | Viewed by 1143 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention

edited by

Jia-Feng Chang

and

Chih-Hsin Tang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1032 | Submission Open

Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications

edited by

Qibiao Wu

and Hiu Yee Kwan

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1030 | Submission Open

Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application

(This special issue belongs to the Section Molecular Oncology)

Proteases and Their Inhibitors: From Biochemistry to Applications

edited by

Gonzalo Izaguirre

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1022 | Submission Open

Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics

edited by

Vladimir N. Uversky

submission deadline 20 Dec 2025 | 1 articles | Viewed by 974 | Submission Open

Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography

(This special issue belongs to the Section Molecular Biophysics)

Recent Advances in Biomolecular Recognition: 3rd Edition

edited by

Ray Luo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 967 | Submission Open

Keywords: proteins; nucleic acids; membrane; ligand; binding

(This special issue belongs to the Section Molecular Biophysics)

Molecular Studies of Skin Diseases: From Mechanisms to Therapy

edited by

Soon Hyo Kwon

submission deadline 20 Dec 2025 | 2 articles | Viewed by 940 | Submission Open

Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Protein Folding and Misfolding

edited by

Ho-Jin Lee

submission deadline 20 Dec 2025 | Viewed by 849 | Submission Open

Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9

(This special issue belongs to the Section Molecular Biophysics)

Electron Transport Mechanism in Optoelectronic Materials

edited by Paolo Umari

submission deadline 20 Dec 2025 | Viewed by 802 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Action and Cytotoxicity of Platinum-Based Therapeutics

edited by

Antonella Muscella

submission deadline 20 Dec 2025 | 1 articles | Viewed by 788 | Submission Open

Keywords: platinum-based drugs; cancer therapy; cisplatin; drug resistance; nanodrugs; targeted delivery systems; molecular mechanisms; systemic toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Age-Related Cognitive Decline

edited by

Cristovam Wanderley Picanço Diniz

submission deadline 20 Dec 2025 | Viewed by 701 | Submission Open

Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes

(This special issue belongs to the Section Molecular Neurobiology)

Apoptosis and Autophagy in Cancer Research

edited by