Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

Dear Colleagues,

Numerous liver disorders are closely associated with inflammation and immune alterations, although the majority of the pathways that are involved are still unknown. Investigations conducted in recent years shed some light on the inflammatory cascade in liver cell injury, and the immune–liver axis has gained increased attention. The results of multiple studies have demonstrated that it may induce not only parenchymal damage, but also hepatic fibrosis and subsequent conversion to liver cirrhosis. The anatomical structure and function of the liver can facilitate and modulate the immune response to pathogens but can also lead to antigen-specific tolerance. The unique structure of the hepatic sinusoidal endothelium, which lacks a basement membrane and has fenestrations, leads to the exposure and provides direct contact between blood lymphocytes and antigens presented by endothelial or immune cells (such as hepatic macrophages, so-called Kupffer cells, and dendritic cells). Therefore, different etiologic factors causing damage to either hepatocytes or bile ducts may alter the intrahepatic immune balance and trigger an inflammatory response such as auto-aggression.

The aim of the present Special Issue is to highlight the impact of immunity and inflammation on the pathogenesis and clinical outcome of liver diseases of different origins, as well as providing a possible contribution to the prevention of disease progression and treatment. We are honored to invite researchers to submit all types of papers including original, narrative, and systematic reviews to this Special Issue in order to widen our knowledge of immune–hepatic interactions and their implications for human health. Papers are expected to be submitted before the end of May 2025.

Kind regards,

Prof. Dr. Beata Kasztelan-Szczerbińska
Guest Editor

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