Epilepsy: From Molecular Basis to Therapy, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 843
Special Issue Editor
Interests: epilepsy; neuronal inhibition; neuronal regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epilepsy is a generalizable neuropathology arising from a wide range of etiologies, including genetic malfunctions, metabolic disorders, and brain trauma. Regardless of the underlying cause, an imbalance between excitatory and inhibitory neurotransmission is often associated with epilepsy. A better understanding of the molecular mechanisms governing proper excitatory and inhibitory neurotransmission is therefore important for identifying relevant therapeutic targets. In this Special Issue, we aim to cover the latest research on the molecular mechanisms underlying epileptogenesis, as well as rational therapeutic designs based on the latest knowledge. We will focus specifically on three areas of research: (1) ion channels or transporters that underlie excitatory and inhibitory neurotransmissions, (2) the reversibility of excitatory and inhibitory neurotransmissions during epileptogenesis, and (3) epilepsy models that enable systematic investigations into rational approaches for therapeutic design, including molecularly based targeted therapies such as gene therapy and chaperone therapies.
Yours faithfully,
Dr. Henry Hing Cheong Lee
Guest Editor
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Keywords
- genetic epilepsy
- post-traumatic epilepsy
- neurodevelopmental disorder
- glutamate
- GABA
- ionic homeostasis
- disease-modifying therapy
- in vitro
- in vivo
- animal model
- gene replacement therapy
- gene editing
- protein misfolding
- small molecule
- pharmacokinetics
- pharmacodynamics
- translational research
- biomarker
- clinical trial
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