Molecular Mechanisms of Action and Cytotoxicity of Platinum-Based Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 769
Special Issue Editor
Interests: signal transduction; hormones; apoptosis; autophagy; metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Platinum-based therapies, including cisplatin, carboplatin, and oxaliplatin, are widely used for the chemotherapeutic eradication of various cancers. However, their clinical application is limited by severe side effects, including systemic toxicity and drug resistance. Recent advancements in nanotechnology have introduced innovative modifications, such as platinum nanoclusters and targeted delivery systems, which aim to enhance therapeutic efficacy while simultaneously minimizing adverse effects. These approaches offer improved tumor selectivity, reduced toxicity, and potential applications in overcoming drug resistance. In addition to DNA damage, other key mechanisms of platinum drugs include ER stress, acidification of the cytoplasm, disruption of RNA transcription, inhibition of key oncogenic proteins, and a decrease in the metabolic plasticity of cancer cells, in addition to changes in their mechanobiology. Researchers continue to explore molecular mechanisms, innovative drug designs, and combination therapies to expand the therapeutic utility of platinum-based drugs. This issue explores the latest insights into the molecular mechanisms of action, cytotoxicity, and innovative approaches to improve the therapeutic index of platinum-based agents.
Dr. Antonella Muscella
Guest Editor
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Keywords
- platinum-based drugs
- cancer therapy
- cisplatin
- drug resistance
- nanodrugs
- targeted delivery systems
- molecular mechanisms
- systemic toxicity
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