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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms

edited by

Emanuela Stampone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2799 | Submission Open

Keywords: cell cycle; cell division; cyclins; cyclin-dependent kinases (CDKs); biochemical regulative mechanisms

(This special issue belongs to the Section Biochemistry)

Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms

edited by

Tosin Olasehinde

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2721 | Submission Open

Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory

(This special issue belongs to the Section Molecular Toxicology)

Imaging Molecules in Biomedical Research

edited by

Manuela Malatesta

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2720 | Submission Open

Keywords: biomedicine; histochemistry; immunohistochemistry; in situ hybridization; magnetic resonance imaging; optical imaging; photoacoustic imaging; ultrasound imaging; Raman microscopy

(This special issue belongs to the Section Biochemistry)

The Role of Thyroid Hormone in Health and Disease

edited by Sandra Incerpi and Jens Z. Pedersen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2685 | Submission Open

Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Genetics and Breeding for Sugar Crops

edited by Muqing Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2602 | Submission Open

Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene

(This special issue belongs to the Section Molecular Plant Sciences)

Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases

edited by

Takuro Miyazaki

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2542 | Submission Open

Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase

(This special issue belongs to the Section Molecular Biology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2527 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Challenges in Molecularly Imprinted Materials

edited by

Monika Sobiech

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2488 | Submission Open

Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization

(This special issue belongs to the Section Materials Science)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2487 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2472 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Rhizobia

edited by

Socorro Mesa

, María J. Delgado and

Germán Tortosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2361 | Submission Open

Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis

(This special issue belongs to the Section Molecular Microbiology)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2212 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress and Mitochondria in Human Diseases

edited by

Alejandra Espinosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2202 | Submission Open

Keywords: mitochondrial dynamics; ROS; antioxidants; mitophagy; oxidative damage; lipid peroxidation; neurodegenerative diseases; cancer; obesity

(This special issue belongs to the Section Biochemistry)

Molecular Research of Abiotic Stress in Plants

edited by Deguo Han

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2084 | Submission Open

Keywords: abiotic stress; salt stress; drought stress; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease

edited by

Alberto Ouro

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2001 | Submission Open

Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Gastrointestinal Cancer, 3rd Edition

edited by

Aneta Koronowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1989 | Submission Open

Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair

edited by Anisa Shaker

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1973 | Submission Open

Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Peptides in Reproductive Health and Disease

edited by

Ga-Hyun Son

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1971 | Submission Open

Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Treatment of Neurodegenerative Diseases with Natural Products

edited by

Eugene Huh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1969 | Submission Open

Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition

edited by

Anna D. Kozhevnikova

and

Ilya Vladimirovich Seregin

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1858 | Submission Open

Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis

(This special issue belongs to the Section Molecular Plant Sciences)

Sleep and Breathing: From Molecular Perspectives

edited by Alberto Alonso-Fernández

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1710 | Submission Open

Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics

(This special issue belongs to the Section Molecular Biology)

New Insights into Photosystem I (Second Edition)

edited by

Stefano Santabarbara

and

Gary Hastings

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1704 | Submission Open

Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Research in Probiotic Yeasts: Molecular Aspects

edited by

Maurizio Ciani

and

Francesca Comitini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1699 | Submission Open

Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds

(This special issue belongs to the Section Molecular Microbiology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1665 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

Intestinal Diseases and Gut Microbiota

edited by

Anna Duda-Madej

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1642 | Submission Open

Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing

edited by

Mun Bong-Gyu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1625 | Submission Open

Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine

edited by

Tomasz Urbanowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1607 | Submission Open

Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Anticancer Strategies

edited by

Yong Teng

submission deadline 20 Dec 2025 | Viewed by 1582 | Submission Open

Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1568 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

Biocomposite Hydrogels for Biomedical Applications

edited by

Leonard Ionut Atanase

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1560 | Submission Open

Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing

(This special issue belongs to the Section Materials Science)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1559 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Epilepsy: From Molecular Basis to Therapy, 2nd Edition

edited by

Henry Hing Cheong Lee

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1532 | Submission Open

Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Ion Channels in Human Health and Diseases

edited by

Sheng-Nan Wu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1490 | Submission Open

Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology

(This special issue belongs to the Section Molecular Biology)

Insights into Functional Nanomaterials: Application-Related Structural Analysis

edited by Zoltán Dudás

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1461 | Submission Open

Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Virus-Host Immune Interactions

edited by

Claudia Vanetti

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1391 | Submission Open

Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2

(This special issue belongs to the Section Molecular Immunology)

Neural Stem Cells: Latest Applications and Future Perspectives

edited by

Evangelos Delivopoulos

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1377 | Submission Open

Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Plant Reproductive Development

edited by Zsolt Pónya and

Iman Mirmazloum

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1371 | Submission Open

Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1344 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

The Role of Non-Coding RNAs in Female Reproduction

edited by

Angela Caponnetto

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1321 | Submission Open

Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network

(This special issue belongs to the Section Molecular Genetics and Genomics)

Regulatory Mechanisms Underlying Tumorigenesis

edited by

Kazuhiko Kuwahara

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1248 | Submission Open

Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models

(This special issue belongs to the Section Molecular Oncology)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 20 Dec 2025 | Viewed by 1142 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention

edited by

Jia-Feng Chang

and

Chih-Hsin Tang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1028 | Submission Open

Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications

edited by

Qibiao Wu

and Hiu Yee Kwan

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1014 | Submission Open

Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application

(This special issue belongs to the Section Molecular Oncology)

Proteases and Their Inhibitors: From Biochemistry to Applications

edited by

Gonzalo Izaguirre

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1013 | Submission Open

Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Biomolecular Recognition: 3rd Edition

edited by

Ray Luo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 964 | Submission Open

Keywords: proteins; nucleic acids; membrane; ligand; binding

(This special issue belongs to the Section Molecular Biophysics)

25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics

edited by

Vladimir N. Uversky

submission deadline 20 Dec 2025 | 1 articles | Viewed by 961 | Submission Open

Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography

(This special issue belongs to the Section Molecular Biophysics)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 20 Dec 2025 | 2 articles | Viewed by 927 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Studies of Skin Diseases: From Mechanisms to Therapy

edited by

Soon Hyo Kwon

submission deadline 20 Dec 2025 | 2 articles | Viewed by 894 | Submission Open

Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Protein Folding and Misfolding

edited by

Ho-Jin Lee

submission deadline 20 Dec 2025 | Viewed by 848 | Submission Open

Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9

(This special issue belongs to the Section Molecular Biophysics)

Electron Transport Mechanism in Optoelectronic Materials

edited by Paolo Umari

submission deadline 20 Dec 2025 | Viewed by 801 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport

(This special issue belongs to the Section Materials Science)

Displaying special issue 151-200 on page 4 of 66.

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