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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Tomato Breeding and Molecular Research

edited by Silvana Grandillo,

Gianfranco Diretto

and

Maria Cammareri

submission deadline 30 Jan 2026 | 7 articles | Viewed by 18696 | Submission Open

Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Neuroinflammation and Neurodegeneration: Molecular Mechanism and Novel Therapy

edited by

Chih Hung Lo

submission deadline 30 Jan 2026 | 5 articles | Viewed by 17094 | Submission Open

Keywords: neuroinflammation; neurodegeneration; neuroimmunology; toxic protein aggregates; autolysosomal dysfunction; metabolic defects; aberrant receptor signaling; neuron-glia interactions; glia-immune interactions; omics characterizations; therapeutic development; biomarker discovery

(This special issue belongs to the Section Molecular Neurobiology)

Genetic and Epigenetic Influences on Personality Traits and Athletic Performance

edited by

Kinga Huminska-Lisowska

submission deadline 30 Jan 2026 | 2 articles | Viewed by 16899 | Submission Open

Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 30 Jan 2026 | 4 articles | Viewed by 16785 | Submission Open

Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Versatility of Protein Synthesis in a Test Tube

edited by

Tamás Mészáros

submission deadline 30 Jan 2026 | 5 articles | Viewed by 15473 | Submission Open

Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation

(This special issue belongs to the Section Molecular Biology)

The Molecular Basis of Vascular Pathology

edited by

Jolanta Neubauer-Geryk

submission deadline 30 Jan 2026 | 8 articles | Viewed by 15208 | Submission Open

Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Enzymes for Biotechnological Applications: 2nd Edition

edited by

Salvatore Fusco

submission deadline 30 Jan 2026 | 4 articles | Viewed by 15156 | Submission Open

Keywords: microbial enzymes; whole-cell biocatalysts; extremozyme; enzyme assays; protein engineering

(This special issue belongs to the Section Biochemistry)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 30 Jan 2026 | 3 articles | Viewed by 14570 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Molecular Precision Medicine: Unraveling Novel Mechanisms and Delivery Strategies in Complex Diseases

edited by

Nuno Vale

submission deadline 30 Jan 2026 | 4 articles | Viewed by 11956 | Submission Open

Keywords: molecular precision therapeutics; disease biomarkers; novel therapeutic molecules; drug delivery strategies; personalized medicine; bioinformatics; nanotechnology; synthetic biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Programmed Cell Death and Oxidative Stress: 3rd Edition

edited by

Takuya Noguchi

submission deadline 30 Jan 2026 | 10 articles | Viewed by 11749 | Submission Open

Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Research on Cancer Treatments: Apoptosis, Autophagy, and Drug Selection

edited by

Md Ataur Rahman

submission deadline 30 Jan 2026 | 4 articles | Viewed by 11551 | Submission Open

Keywords: autophagy; apoptosis; bioactive natural products; nanoparticles and drug delivery; cancer immunotherapy; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Liposome-Based Drug Delivery Systems

edited by

Shao-Ling Huang

submission deadline 30 Jan 2026 | 4 articles | Viewed by 11281 | Submission Open

Keywords: liposomes; targeted delivery; controlled release; nanotechnology; drug delivery; diagnostics; therapeutics; multifunctional liposomes; phospholipids

(This special issue belongs to the Section Molecular Pharmacology)

New Trends in Biologically Active Compounds in Age-Related Diseases

edited by Celia Andrés Juan

submission deadline 30 Jan 2026 | 3 articles | Viewed by 9308 | Submission Open

Keywords: age-related diseases; oxidative stress and inflammation; energy failure; mitochondrial dysfunction; deregulated autophagy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Glia in Human Health and Disease

edited by

Daniele Lana

and

Hajime Hirase

submission deadline 30 Jan 2026 | 7 articles | Viewed by 9203 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

High Fat Diet Metabolism and Diseases

edited by

Miguel Walter Fornés

and

Luís Fernando Barbisan

submission deadline 30 Jan 2026 | 6 articles | Viewed by 8271 | Submission Open

Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Regulation in Blood-Brain Barrier

edited by Rajkumar Vutukuri

submission deadline 30 Jan 2026 | 2 articles | Viewed by 8200 | Submission Open

Keywords: blood brain barrier (BBB); tight junctions; NVU cell types; neurodegenerative diseases; neuro-inflammation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 30 Jan 2026 | 2 articles | Viewed by 8195 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

Molecular Engineering in Dental Restorative and Regenerative Materials

edited by

Danijela Marović

submission deadline 30 Jan 2026 | 5 articles | Viewed by 8099 | Submission Open

Keywords: dental composites; ceramics; additive manufacturing; dental adhesives; bioactive; 3D printing; photopolymerization; curing devices; microstructure; degree of conversion; bulk-fill composites; lasers in dentistry; infrared spectroscopy; biocompatibility; bone regeneration; osseointegration; soft tissue regeneration

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Zinc Finger Proteins in Biological Processes and Diseases

edited by

Amelia Casamassimi

and Patrizia Gazzerro

submission deadline 30 Jan 2026 | 4 articles | Viewed by 7982 | Submission Open

Keywords: zinc finger domain; CTCF; PRDM family; nuclear receptors; human diseases; transcriptional regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Biophysics)

Molecular Advances in Combinatorial Therapies for Spinal Cord Injury

edited by

Lingxiao Deng

submission deadline 30 Jan 2026 | 1 articles | Viewed by 7856 | Submission Open

Keywords: molecular; cellular; engineering; spinal cord injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Aspects of Colorectal Cancer

edited by

Christos K. Kontos

submission deadline 30 Jan 2026 | 4 articles | Viewed by 7792 | Submission Open

Keywords: colorectal adenocarcinoma; cancer pathobiology; molecular biomarkers; diagnosis and prognosis; prediction of therapy selection; therapeutic targets; RNA molecules; microRNA; long non-coding RNA; circular RNA

(This special issue belongs to the Section Molecular Oncology)

Advances in Antimicrobial Nanomaterials 2.0

edited by

Irena Maliszewska

submission deadline 30 Jan 2026 | 3 articles | Viewed by 7681 | Submission Open

Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents

(This special issue belongs to the Section Molecular Nanoscience)

The Role of the IGF Axis in Disease, 4th Edition

edited by Claire M. Perks

submission deadline 30 Jan 2026 | 3 articles | Viewed by 7206 | Submission Open

Keywords: IGF axis; cancer; obesity; hallmarks of cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Photobiomodulation Therapy

edited by Maria Fernanda Setúbal Destro Rodrigues

submission deadline 30 Jan 2026 | 3 articles | Viewed by 7060 | Submission Open

Keywords: photobiomodulation; dosimetric parameters; human diseases; modulation of inflammation; photobiomodulation therapy; molecular mechanisms; preclinical and clinical studies; therapeutic applications of PBM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease

edited by David Rohde

submission deadline 30 Jan 2026 | 5 articles | Viewed by 6686 | Submission Open

Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Novel Treatment Strategies for Head and Neck Cancer

edited by

Francesca Spirito

submission deadline 30 Jan 2026 | 1 articles | Viewed by 6128 | Submission Open

Keywords: head and neck cancer; drug resistance; cancer initiation; biomarker

(This special issue belongs to the Section Molecular Oncology)

Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition

edited by

Peter Koulen

submission deadline 30 Jan 2026 | 3 articles | Viewed by 6088 | Submission Open

Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxic Liver Injury: Molecular, Mechanistic, and Medical Challenges 3.0

edited by

Rolf Teschke

submission deadline 30 Jan 2026 | 3 articles | Viewed by 6023 | Submission Open

Keywords: liver injury; nonalcoholic fatty liver disease; nonalcoholic steatonecrosis; nonalcoholic liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging

edited by

Lia Ginaldi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 5572 | Submission Open

Keywords: aging; age-related; immunosenescence; immune system; inflammaging

(This special issue belongs to the Section Molecular Immunology)

From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology

edited by

Alexis A. Gonzalez

submission deadline 30 Jan 2026 | 3 articles | Viewed by 5446 | Submission Open

Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Food Science and Molecular Nutrition

edited by

Hsinjung Ho

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5436 | Submission Open

Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics

(This special issue belongs to the Section Biochemistry)

Molecular Aspects of Forensic Toxicology

edited by

Angelo Montana

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5100 | Submission Open

Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro; in vivo; and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Toxicology)

New Insights into Autophagy and Retinal Degeneration

edited by

Francesco Fornai

submission deadline 30 Jan 2026 | 1 articles | Viewed by 4806 | Submission Open

Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Crustacean Aquaculture

edited by Tom Levy and

Tomer Ventura

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4739 | Submission Open

Keywords: androgenic gland; aquaculture; crustaceans; disease management; gene silencing; genetic modification; monosex; selective breeding; sex reversal; yield improvement

(This special issue belongs to the Section Molecular Biology)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4567 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling Sugar Signaling: Insights into Plant Stress Responses

edited by

Claudia Uhde-Stone

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4523 | Submission Open

Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Design, Synthesis and Applications of the Task-Specific Molecules

edited by

Ye Yuan

and

Yang Yang

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4082 | Submission Open

Keywords: task-specific molecules; molecular design and synthesis; physical/chemical absorption; catalysis (including electrocatalysis; photocatalysis; etc.); mechanism on the molecular level; molecular dynamic simulations; optical materials; optoelectronic devices; photoelectric detection; semiconductors

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Latest Molecular Advances in Autophagy

edited by

Gloria Riitano

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3930 | Submission Open

Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK

(This special issue belongs to the Section Molecular Biology)

New Insights into Hyaluronan in Human Medicine

edited by

Monica Salamone

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3752 | Submission Open

Keywords: hyaluronan; regenerative medicine; inflammation; cancer therapy; metabolomics ; hyaluronidases; cell– matrix interaction; glucose metabolism; pathological processes

(This special issue belongs to the Section Biochemistry)

Metals and Metal Ions in Human Health, Diseases, and Environment

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3475 | Submission Open

Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution

(This special issue belongs to the Section Molecular Biology)

Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions

edited by

Piotr Dobrowolski

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2850 | Submission Open

Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Glutamine Metabolism in Cancer

edited by

Andrew R. Green

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2736 | Submission Open

Keywords: glutamine metabolism; cancer; oncometabolism; cancer metabolism; metabolic reprogramming; personalised medicine; therapeutic resistance; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2645 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Innovations in Synthetic Organic Chemistry

edited by Anand H. Shinde

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2619 | Submission Open

Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry

(This special issue belongs to the Section Biochemistry)

Drug Development Breakthroughs: From Novel Antimicrobials to Targeted Cancer Drugs

edited by

Christos Papaneophytou

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2600 | Submission Open

Keywords: drug development; molecular science; small-molecule inhibitors; biopharmaceuticals; peptides; cancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer

edited by

Inamul Haque

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2522 | Submission Open

Keywords: drug resistance; cancer therapy; targeted therapy; nanotechnology; tumor microenvironment; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2505 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges

edited by

Elena Grossini

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2418 | Submission Open

Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics

edited by

Simona Dedoni

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2086 | Submission Open

Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dynamics Simulations of Nanobubble for Different Applications

edited by

Ebrahim Kadivar

submission deadline 30 Jan 2026 | 3 articles | Viewed by 2074 | Submission Open

Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 801-850 on page 17 of 67.

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