Role and Application of Stem Cells in Regenerative Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 166477
Special Issue Editors
Interests: stem cells; dentistry; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Interests: regenerative medicine; stem cells; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; epithelial–mesenchymal transition; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals
Interests: regenerative medicine; stem cells; microfluidics; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal stem cells (MSCs) are currently being used in preclinical and clinical trials for their aptitude to promote wound healing and tissue regeneration.
In particular, oral-derived Mesenchymal Stem Cells (oral-MSCs) represent accessible sites available for stem cell collection and they can be used in regenerative medicine, avoiding the ethical concerns. They can be derived from different oral tissues, such as human exfoliated deciduous teeth (SHED), periodontal ligament (PDLSCs), dental follicle progenitor cells (DFPCs), apical papilla (SCAP), dental pulp (DPSCs) and gingival tissue (GMSCs), and posses multipotential, proliferation and differentiation abilities. Moreover, oral-MSCs represent paracrine and immunomodulatory capacity, an innovative tool for the treatment of various degenerative and traumathic processes, including skeletal and maxilla-facial degeneration, trauma or ischemia injuries, neurodegenerative, as well as immune disorders.
This Special Issue, “Role and Application of Stem Cells in Regenerative Medicine”, of the International Journal of Molecular Sciences will comprise a selection of research papers and reviews that will contribute in the evaluation of aptitude, in particular, of oral-MSCs and their secretome in terms of tissue regeneration, as a starting point for the fabrication of 3D-living constructs for future clinical applications.
Moreover, to better understand the molecular mechanisms involved in tissue regeneration, in vitro and in vivo studies will provide a possible high impact in the development of stem cell based regeneration strategies and in the identification of the key biological regulation processes that remain uncovered.
Prof. Dr. Oriana Trubiani
Dr. Jacopo Pizzicannella
Dr. Francesca Diomede
Guest Editors
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Keywords
- Mesenchymal stem cells
- Tissue reggeneration
- Regenerative medicine
- Immunomodulatory process