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Strategic Tools in Regenerative and Translational Dentistry

Department of Regenerative Medicine, Tecnologica Research Institute, 88900 Crotone, Italy
Department of Experimental Medicine, Marrelli Hospital, 88900 Crotone, Italy
Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia
Department of NHS Foundation Trust, University Hospitals Birmingham – NHS Foundation Trust, Birmingham B152GW, UK
Author to whom correspondence should be addressed.
These authors equally contributed to the manuscript.
Int. J. Mol. Sci. 2019, 20(8), 1879;
Received: 29 March 2019 / Revised: 10 April 2019 / Accepted: 14 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Role and Application of Stem Cells in Regenerative Medicine)
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Human oral-derived stem cells can be easily obtained from several oral tissues, such as dental pulp, periodontal ligament, from gingiva, or periapical cysts. Due to their differentiation potential, oral-derived mesenchymal stem cells are promising for tissue engineering and regenerative medicine. The regenerative ability showed by some oral tissues strongly depends on their sleeping adult stem cell populations that are able to repair small defects and to manage local inflammation. To date, researchers are working on effective and efficient methods to ensure safe and predictable protocols to translate stem cell research into human models. In the last decades, the challenge has been to finally use oral-derived stem cells together with biomaterials or scaffold-free techniques, to obtain strategic tools for regenerative and translational dentistry. This paper aims to give a clear point of view on state of the art developments, with some exciting insights into future strategies. View Full-Text
Keywords: oral-derived stem cells; regenerative medicine; dental pulp stem cells; waste medicine; tissue engineering oral-derived stem cells; regenerative medicine; dental pulp stem cells; waste medicine; tissue engineering

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Tatullo, M.; Codispoti, B.; Paduano, F.; Nuzzolese, M.; Makeeva, I. Strategic Tools in Regenerative and Translational Dentistry. Int. J. Mol. Sci. 2019, 20, 1879.

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