Next Article in Journal
Clinical and Biological Significance of ESR1 Gene Alteration and Estrogen Receptors Isoforms Expression in Breast Cancer Patients
Next Article in Special Issue
Expression of Musashi-1 During Osteogenic Differentiation of Oral MSC: An In Vitro Study
Previous Article in Journal
Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder
Previous Article in Special Issue
Oxidative Stress-Tolerant Stem Cells from Human Exfoliated Deciduous Teeth Decrease Hydrogen Peroxide-Induced Damage in Organotypic Brain Slice Cultures from Adult Mice
Article Menu
Issue 8 (April-2) cover image

Export Article

Open AccessReview

Strategic Tools in Regenerative and Translational Dentistry

1
Department of Regenerative Medicine, Tecnologica Research Institute, 88900 Crotone, Italy
2
Department of Experimental Medicine, Marrelli Hospital, 88900 Crotone, Italy
3
Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia
4
Department of NHS Foundation Trust, University Hospitals Birmingham – NHS Foundation Trust, Birmingham B152GW, UK
*
Author to whom correspondence should be addressed.
These authors equally contributed to the manuscript.
Int. J. Mol. Sci. 2019, 20(8), 1879; https://doi.org/10.3390/ijms20081879
Received: 29 March 2019 / Revised: 10 April 2019 / Accepted: 14 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Role and Application of Stem Cells in Regenerative Medicine)
  |  
PDF [1173 KB, uploaded 16 April 2019]
  |  

Abstract

Human oral-derived stem cells can be easily obtained from several oral tissues, such as dental pulp, periodontal ligament, from gingiva, or periapical cysts. Due to their differentiation potential, oral-derived mesenchymal stem cells are promising for tissue engineering and regenerative medicine. The regenerative ability showed by some oral tissues strongly depends on their sleeping adult stem cell populations that are able to repair small defects and to manage local inflammation. To date, researchers are working on effective and efficient methods to ensure safe and predictable protocols to translate stem cell research into human models. In the last decades, the challenge has been to finally use oral-derived stem cells together with biomaterials or scaffold-free techniques, to obtain strategic tools for regenerative and translational dentistry. This paper aims to give a clear point of view on state of the art developments, with some exciting insights into future strategies. View Full-Text
Keywords: oral-derived stem cells; regenerative medicine; dental pulp stem cells; waste medicine; tissue engineering oral-derived stem cells; regenerative medicine; dental pulp stem cells; waste medicine; tissue engineering
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tatullo, M.; Codispoti, B.; Paduano, F.; Nuzzolese, M.; Makeeva, I. Strategic Tools in Regenerative and Translational Dentistry. Int. J. Mol. Sci. 2019, 20, 1879.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top