Interplay between Pre-mRNA Splicing and Other Gene Expression Steps in Eukaryotes 2.0

Dear Colleagues,

In eukaryotes, RNAs transcribed from genomic DNA are subjected to many regulatory processes, indicating their pivotal role in gene expression. Pre-mRNA splicing is a process to remove introns and ligate exons so that mRNA can be produced. This step is critical for higher eukaryotes and is vigorously regulated. After finding the Exon Junction Complex, several lines of evidence have noted that pre-mRNA splicing and other gene expression steps have influence over each other and there is an interplay between pre-mRNA splicing and other gene expression in higher eukaryotes.

As the Guest Editor of this Special Issue, “Interplay between Pre-mRNA Splicing and Other Gene Expression Steps in Eukaryotes”, in IJMS, I expect submissions from many researchers working on the wide spectrum of physiological processes in which RNAs are involved. The focus of this topic is the molecular link between pre-mRNA splicing and other steps in eukaryotes. Examples for this Special Issue include transcription-coupled splicing, coupling of splicing and mRNA export/localization, nonsense-mediated mRNA decay, enhancement of translation, and signal transduction pathway modulation by alternative splicing. Manuscripts regarding splicing changes during the development of organisms and aberrant splicing in human diseases are also very welcome. The formats for submissions include original research reports, reviews, perspectives/opinions and methodology articles.

Dr. Naoyuki Kataoka
Guest Editor

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