Molecular Aspects of Degeneration and Regeneration in the Peripheral Nervous System

Dear Colleagues,

In the peripheral nervous system, the intrinsic regenerative capacity of neurons coupled with permissive environments due to the activation of Schwann cells and macrophages during Wallerian degeneration contributes to axonal regeneration and reinnervation after injury. However, there is much room for investigation to elucidate the molecules and mechanisms involved in the repair process (e.g., neurotrophic and chemotactic factors, growth inhibitory molecules, and extracellular matrix conctituents), and clinical approaches for accelerating axonal regeneration with functional restoration remain insufficient. In addition, peripheral neuropathies caused by various etiologic mechanisms (e.g., genetic abnormalities, immune system disorders, drugs, diabetes, and other life style-related diseases) are intractable, and pathogenesis-based therapies to treat them have been unsuccessful or incomplete thus far. This Special Issue focuses on recent topics pertinent to the molecular aspects of peripheral nerve degeneration and regeneration following axonal injury; the development and progression of neuropathies; and therapeutic strategies against these lesions, including cell and tissue transplantation and neural interface.

Dr. Kazunori Sango
Guest Editor

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