Transport Mechanisms of Mitochondrial Membrane Proteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 20232
Special Issue Editors
Interests: functional proteomics; membrane proteins; membrane transport; mitochondrial carrier biogenesis; mitochondrial carrier diseases; mitochondrial carrier identification; mitochondrial carrier transcriptional regulation; mitochondrial transport proteins; structure/function relationship; transport mechanism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A Special Issue on “Transport Mechanisms of Mitochondrial Membrane Proteins” is being prepared for the International Journal of Molecular Sciences.
The two mitochondrial membranes contain a large number of membrane proteins involved in various transport functions, for example the outer membrane VDAC, the inner membrane mitochondrial carriers (SLC25 superfamily members), ATP binding cassette transporters and respiratory chain electron transfer complexes. Whereas the outer membrane proteins provide a more general selective permeability filter for diffusion, the inner membrane proteins are highly selective for their transported substrates such as nucleotides, ions, protons, electrons, metabolites, amino acids and cofactors. Biochemical characterization of the mitochondrial membrane proteins has established substrate specificity, kinetic parameters and modes of transport (antiport, uniport or symport). Transport mechanisms of various mitochondrial membrane proteins have been proposed based on transport kinetics, inhibitor studies, modes of transport, mutagenesis and, in particular, structural analyses and dynamics.
Original manuscripts and reviews examining different aspects of the transport mechanisms of the mitochondrial membrane proteins are welcome.
Prof. Dr. Ferdinando Palmieri
Dr. Magnus Monné
Guest Editors
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Keywords
- mitochondrial carriers
- transport mechanism
- transport cycle
- mitochondrial ADP/ATP carrier
- kinetics of transport
- antiport transport
- uniport transport
- symport transport
- structures of transporters
- regulation of transport
- structure-function relationships of transporters
- inhibitors of transporters
- molecular dynamics simulations of transporters
- site-directed mutagenesis
- transport assays
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