Transport Mechanisms of Mitochondrial Membrane Proteins

Dear Colleagues,

A Special Issue on “Transport Mechanisms of Mitochondrial Membrane Proteins” is being prepared for the International Journal of Molecular Sciences.

The two mitochondrial membranes contain a large number of membrane proteins involved in various transport functions, for example the outer membrane VDAC, the inner membrane mitochondrial carriers (SLC25 superfamily members), ATP binding cassette transporters and respiratory chain electron transfer complexes. Whereas the outer membrane proteins provide a more general selective permeability filter for diffusion, the inner membrane proteins are highly selective for their transported substrates such as nucleotides, ions, protons, electrons, metabolites, amino acids and cofactors. Biochemical characterization of the mitochondrial membrane proteins has established substrate specificity, kinetic parameters and modes of transport (antiport, uniport or symport). Transport mechanisms of various mitochondrial membrane proteins have been proposed based on transport kinetics, inhibitor studies, modes of transport, mutagenesis and, in particular, structural analyses and dynamics.

Original manuscripts and reviews examining different aspects of the transport mechanisms of the mitochondrial membrane proteins are welcome.

Prof. Dr. Ferdinando Palmieri
Dr. Magnus Monné
Guest Editors

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