Mitochondrial Targeting as an Efficient Anti-cancer Therapy

Dear Colleagues,

Despite an enormous amount of research focused on cancer diagnosis, biology, and treatment, neoplastic diseases remain the second leading cause of death worldwide. One of the main challenges is the identification of an invariant and essential target present in a wide variety of malignancies. Almost a century ago, Otto Warburg published his observations on the preference of cancer cells to produce energy through glycolysis even under aerobic conditions, leading to the conclusion that mitochondria of cancer cells are damaged and cannot be used to produce energy via oxidative phosphorylation. However, further research has shown that, although these organelles might not always supply cancer cells with energy, they are key organelles in tumor formation and maintenance. Therefore, understanding the diverse roles of mitochondria in carcinogenesis and selectively targeting their function has recently gathered intense focus as a viable alternative to develop novel and effective anti-cancer treatments. This Special Issue aims to gather recent insights in mitochondrial biology and function in cancer and, most importantly, document the approaches that utilize mitochondrial targeting in the context of cancer treatment.

Dr. Cristián Sandoval-Acuña
Dr. Jaroslav Truksa
Guest Editors

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