Metabolic Therapies for the Treatment of Cancer

Dear Colleague

Metabolic alteration is a hallmark of cancer shared by virtually all tumor cells. In 1927 Otto Warburg demonstrated differences in glucose uptake and production of lactate between non-neoplastic and neoplastic cells. Tumor cells show a shift toward increased glycolytic flux in the cytosol and away from the tricarboxylic acid cycle and oxidative phosphorylation in the mitochondria. This occurs very early in tumorigenesis and allows for rapid cell proliferation even under conditions of hypoxia and in the presence of dysfunctional mitochondria.

While many early metabolic studies centered primarily on bioenergetics (particularly glucose and glutamine utilization), we now know that many other metabolic pathways are also reprogrammed in cancer, with all apparently inexorably intertwined with key components of tumor initiation, progression and therapy response.

This Special Issue will focus on pharmacologic and dietary therapies that target tumor metabolism to inhibit the growth of tumor cells and/or enhance the efficacy of currently available cytotoxic and immune therapies. Authors are invited to submit original research and review articles describing translational, preclinical and clinical studies relating to their efficacy and mechanisms of action when used alone or in combination with standard therapies.

Dr. Adrienne C. Scheck
Dr. Angela M. Poff
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.