High Resolution Mass Spectrometry in Molecular Sciences

Dear Colleagues,

An aspiration for high resolution, accuracy and sensitivity in spectroscopic and spectrometric methods can be paraphrased by the Olympic motto of Citius, Altius, Fortius (faster, higher, stronger). Demands for high mass-resolving power and mass-measurement accuracy, as well as for speedy data acquisition, have been the driving forces toward advances of instrumentation that facilitate the pursuit of challenging applications of mass spectrometry. The introduction of the Fourier transform (FT) approach and the development of the high-resolution time-of-flight (TOF) method of ion sorting have enabled a paradigm shift to meet these challenges. FT ion cyclotron resonance (FT-ICR), Orbitrap and TOF instruments are commercially available in many of today’s mass spectrometers and often in “hybrid” configurations that bring them together seamlessly with other analyzers, such as quadrupoles and ion traps within one instrument. They now deliver superior performance to the delight of the broad scientific community—the masses, when one plays with the multiple meanings of the word. In addition to conventional research articles and reviews, this Special Issue (expanded in breadth from an earlier series of IJMS articles devoted to Fourier transform mass spectrometry) also welcomes commentaries, opinions and perspectives on the progress and applications of high-resolution mass spectrometry in broad areas of the molecular sciences.

Prof. Dr. Laszlo Prokai
Guest Editor

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