Epigenomics of Complex Traits and Diseases

Dear Colleagues,

Genome-wide genetic information for human populations and phenotypes is becoming increasingly abundant because of the efforts of genomes sequencing projects and the recent wave of genome-wide association studies (GWASs) in human complex traits. Thousands of genetic variants have been associated with diseases and complex traits, with very good estimates of the effect size and the significance of the effects. While this is a major milestone in human genetics, these studies generally failed in their primary intent. Despite the hundreds of millions of dollars spent on genome-wide association studies, most of the genetic variance in the risks for the most common diseases remains undiscovered. Recent advances in genomic technologies have placed us in a position to initiate large-scale studies of human disease-associated epigenetic variation, specifically variations in DNA methylation. Epigenetics appears to be an interesting opportunity to shed light on the genomic contribution in the field of complex traits and diseases.

Topics of this Special Issue include, but are not limited to, the following:

• Genetic and epigenetic variability of complex traits and diseases
• Genetics and epigenetics of aging
• Epigenetics modification in cancer
• Epigenomic-wide association studies in the field of complex traits and diseases
• Methodological approaches for the integration of omic data

Dr. Davide Gentilini
Guest Editor

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