cGMP-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

Dear Colleagues,

Cellular and tissue signaling by cGMP is an expanding field which comprises molecular function and (patho)physiology in various organ systems. cGMP synthesis, degradation, and function are modulated by a variety of signaling proteins and signal transduction pathways. Stuctural, biochemical, and (patho)physiological aspects have been strongly developed in the last decade, e.g., regarding cardiovascular, renal, pulmonary, gastrointestinal, and neuronal function. Dysregulation of cGMP generators (guanylyl cyclases), modulators (phosphodiesterases), and signaling molecules (e.g., kinases/substrates, channels) has been elucidated as the cause of pathophysiological processes and diseases. Pharmacological approaches have been propagated into pharmacological treatments including hypertension, cardiovascular, and gastrointestinal diseases. Therefore, the molecular and functional understanding of the diverse cGMP generators, signalling proteins, scaffolds, and signal transduction pathways is fundamental for insight into their (patho)physiological processes. The scope of the Special Issue is to summarize and enlarge the knowledge of these signaling processes and networks in diverse cells/tissues and to link it to (patho)physiological and pharmacological functions.

Therefore, authors are invited to submit original research and review articles which address the progress and current standing of cGMP signaling.

Topics include but are not limited to:

• Identification of and new molecular and functional aspects in cGMP-signaling molecules and pathways;
• Analysis of cGMP-signal generation, modulation, recognition, and/or its transduction into (patho)physiological responses and/or pharmacologcal approaches;
• Techniques for the analysis and identification of cGMP signalling molecules, scaffolds, pathways, and networks.

Prof. Dr. Jens Schlossmann
Guest Editor

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