Molecular Signaling and Nanobiotechnology: Prospects for Future Antimicrobial Therapy

Dear Colleagues,

Since current antimicrobial approaches are becoming less efficient and the antibiotic resistance phenomenon is emerging, alternative therapies are highly investigated for infection control. Recent progress made in order to limit the development of severe infections show that the modulation of certain bacterial behaviors by using signaling molecules or nanosized structures may reduce pathogenicity and virulence, resulting in mild infections. These small molecules proved their efficiency both in vitro and in vivo studies and are currently considered for the development of alternative and ecological anti-infectious therapies, being mostly represented by natural factors obtained from microbial, plant and even animal cells. Nanotechnology, the science of nanometer sized materials, plays a very important role in the implementation of novel antimicrobial therapies by stabilizing, improving the delivery and efficiency and by reducing side effects of many antimicrobial compounds. Moreover, many nanosized materials proved their antimicrobial efficiency in severe and difficult to treat infections, such as those caused by highly resistant pathogens and biofilm associated infectious diseases. The purpose of this special issue is to reveal the most recent and applicative progress developed on the field of novel antimicrobial approaches by highlighting the impact of signaling molecules and nanostructured biomaterials in the design of future anti-infectious therapies.

Dr. Alexandru Mihai Grumezescu
Dr. Alina Maria Holban
Guest Editors

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