Molecular Alterations in Non-small Cell Lung Cancer: Biology and Therapeutic Implications

Dear Colleagues,

In the last decade, studies on molecular alterations in non-small cell lung cancer (NSCLC) have improved the knowledge on the biological pathways involved in tumor development, as well as specific information involving tumor growth signals, inhibition of apoptosis, stimulation of neoangiogenesis, and escape from immune system.

Some of the detected alterations in NSCLC have led to the evolution of antineoplastic therapies; notable examples are represented by activating mutations of the epidermal growth factor receptor (EGFR) gene; furthermore, the list of potentially actionable target genes in NSCLC is constantly increasing. In addition, some emerging molecular alterations appear to be associated with differences in terms of response to immune checkpoint inhibitors, and the mechanisms leading to these correlations are under investigation.

Finally, the exploitation of multiple molecular determinants in NSCLC in the clinical setting strongly relies on multigenic testing techniques, with specific regards to next generation sequencing (NGS); to date, research labs and comprehensive cancer centers worldwide have been putting efforts in updating testing technology in order to comply with demanding standards.

This special issue explores the role of oncogenic drivers in terms of tumorigenesis and as potential therapeutic targets, as well as the NGS technologies needed to optimize the molecular characterization of NSCLC.

Prof. Dr. Carlo Genova
Guest Editor

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