TRP Channels in Physiology and Pathophysiology

Dear Colleagues,

As many as thirty TRP channels have so far been identified with wide distribution and conservation in most organisms, tissues, and cell types. Being polymodal, TRP channels are activated and regulated by multiple stimuli that include chemical ligands (endogenous and exogenous), heat, cold, mechanical stress, osmotic pressure, vibration, pH, and electrical stimulation. TRPs are cation channels which, via their differential permeability to Ca²⁺, can influence numerous downstream signaling pathways that in turn regulate cellular functions that are as diverse as ion transport and homeostasis, fluid secretion, inflammation, pressure and thermoregulation, vision, taste, sense, and smell. Functional TRP channels have been shown to express in almost all tissues of the body. Thus, malfunction, mutations, and over/under-expression of TRPs play roles in many diseases. Based on this emerging body of work on TRP channels, our aim is to publish a Special Issue of IJMS with research and review articles describing current knowledge and data on the sensing, mechanistic, and functional and pathophysiological roles of TRP channels in tissues. We are seeking articles that explore the roles played by TRP channels at the molecular, biochemical, physiological, pharmacological, and genetic levels and how they impact the development, normal structure and function, and pathology of all tissues.

Dr. Mohammad Shahidullah
Prof. Dr. Paul James Donaldson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.