Special Issue "Identification and Roles of the Structure of DNA"
Deadline for manuscript submissions: closed (30 May 2014).
Interests: higher-order DNA structures; chirality; chromatin folding; topology; DNA unwinding; DNA self-assembly; DNA dynamics; DNA flexibility; kinking; base-pair opening
Special Issues and Collections in MDPI journals
Since its discovery in 1953, the double helix has been mainly considered as a passive support of the genetic information. However, this current view overlooks subtle properties of DNA that possesses all the attributes to be an active player in the cell. Indeed, a complex interplay between the nucleotide sequence and its molecular environment generates DNA structures that may play critical roles in key cellular functions. From local base-pair opening to global topology, the double helix is finely tuned to solve the multiple tasks required to generate and regulate the genetic information. For example, the DNA structure may directly influence the rate of replication errors within the active site of DNA polymerases, but it can also direct chiral DNA–DNA interactions that help to locally sense the global DNA topology by type II topoisomerases. Understanding how DNA may actively contribute to generate, control and spatially organize the genetic information, requires deciphering the complex relationships between the DNA sequence, structure, dynamics and the electrostatic environment. The aim of this Special Issue is to explore these new concepts in combining experimental and theoretical studies.
Dr. Youri Timsit
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Higher-order DNA structures
- chromatin folding
- DNA unwinding
- DNA self-assembly
- DNA dynamics
- DNA flexibility
- base-pair opening