Study on “Stemness” of Cancer Cells and Main Cause of Cancer Relapse after Standard Therapy

Dear Colleagues,

Despite many advances, cancer deaths continue to increase every year worldwide. One of the leading causes of cancer death is relapse after standard therapy. For cancer cells to relapse after standard therapy, therapy-resistant cancer cells must migrate to the recurrence site and proliferate. In this process, cancer cells must survive in adhesion-independent situations, such as circulating tumor cells, and remain resistant to standard therapy. Increasing evidence suggests that not all cells in a heterogenous cancer cell population have the same capacity for it, but certain cells have a higher capacity for it. And, the certain cells that have higher capacity for relapse after standard therapy are often described as having more stem cell-like characteristics, stemness. In this special issue, we will address studies that ultimately aim to control the process of cancer relapse after standard therapy. Original manuscripts and reviews covering the molecular mechanisms of this process, new molecular targets, or new strategies to control this process are welcome. Original manuscripts and reviews dealing with regulation of cancer stemness and studies that can control the survival of circulating tumor cells are also welcome.  

Dr. Hyonchol Jang
Guest Editor

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