New Advances in Hypercapnia

Dear Colleagues,

Cells sense changes in the concentration of gaseous molecules through conserved pathways to elicit adaptive responses and maintain cell homeostasis. Carbon dioxide (CO₂), an atmospheric and physiological gas, is a product of cellular oxidative respiration. The physiological levels of CO₂ in mammals are significantly higher than atmospheric levels (approx. 5% versus approx. 0.04%, respectively) and are linked to physiological conditions. Recent accumulating evidence suggests that the elevation of CO₂ (hypercapnia) is detected by various cells and organisms via as-yet-undescribed mechanisms that lead to specific signaling pathways, many of which are detrimental to cellular and organismal homeostasis. Importantly, these effects of hypercapnia are not limited to mammals.

This Special Issue of IJMS will focus on recent advances in molecular, cellular, and organismal mechanisms of hypercapnia sensing and signaling. We welcome original research and review articles that focus on (but are not limited to) the following topics:

• The molecular mechanisms of CO₂ sensing and signaling;
• The effects of hypercapnia on cellular and organismal functions (humans, animals, flies, nematodes, plants, etc.);
• Potentially advantageous versus disadvantageous effects of hypercapnia;
• Implications on these aspects in human health and diseases.

Dr. Masahiko Shigemura
Guest Editor

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