Mapping Lipid Metabolism in Cancer: Cellular, Metabolic, and Molecular Approaches

Dear Colleagues,

Tumor cells rely heavily on diverse metabolic pathways to support their survival, growth, and proliferation. Among these, lipid metabolism plays a central role by supplying energy, providing essential substrates for membrane biogenesis, and generating signaling molecules that regulate key oncogenic pathways.

In recent years, altered fatty-acid metabolism has gained renewed attention—not only for its contribution to membrane structure, but also for its role in producing secondary messengers that drive cancer progression and metastasis. As a result, targeting fatty-acid pathways has emerged as a promising strategy to uncover metabolic vulnerabilities and enhance the efficacy of existing targeted therapies.

Monitoring lipid-profile changes and characterizing the tumor microenvironment through advanced molecular and metabolic imaging techniques are increasingly fundamental. These approaches help elucidate critical aspects of tumor biology, reveal metabolic adaptations, and identify new therapeutic targets for precision oncology.

Dr. Iorio Egidio
Guest Editor

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