Role of the 2-Oxo Acid Dehydrogenase Complexes in Metabolism: Genetics, Structure and Function

Dear Colleagues, 

The aim of this Special Issue is to bring together the latest research on 2-oxo acid dehydrogenase complexes (OADHc), the key players in cell metabolism, enabling researchers to present their recent findings and to share their opinions on the recent advances in the field.

Recent genetic studies identified several bi-allelic variants in the OGDHL gene that correlated with neurodevelopmental phenotypes, and the rare variants in the OGDHL and DHTKD1 genes were implicated in the genetic ethiology of eosinophilic esophagitis. The reduced activities of the 2-oxoglutarate dehydrogenase complex (OGDHc) in the TCA cycle were correlated with neurodegenerative diseases, particularly Alzheimer’s disease. Recent findings also provided evidence for a close link between the post-translational modifications (PTMs) of proteins by succinylation and glutarylation, as well as the OGDHc and the function of its E2o component identification of target proteins. Therefore, an understanding of the molecular mechanisms of the SIRT 5 (NAD⁺) deacylase remains challenging. Especially interesting are the Cryo-EM structural findings on the OADHc from native cell extracts and on a sample assembled in vitro, which provide a framework for understanding the component assembly and intermediate channeling in these striking enzymatic assemblies with a typical size 4–10 MDa. This research topic will enhance our current understanding of protein interactions in metabolism related to human diseases.

Prof. Dr. Frank Jordan
Dr. Natalia S. Nemeria
Guest Editors

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